Results 11 to 20 of about 2,500 (166)

Synthesis and Biological Assessment of Cyanopyridine‐Based 1,3,4‐Oxadiazole Derivatives: Anticancer Potential, Antioxidant Activity, Molecular Docking, and DFT Calculations [PDF]

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
A series of novel cyanopyridine‐based 1,3,4‐oxadiazole derivatives were synthesized, and their anticancer activities against the MCF‐7 and CaCo‐2 cancer cell lines, as well as their antioxidant capacities, were evaluated under In Vitro conditions. Furthermore, computational studies utilizing Density Functional Theory (DFT) and molecular modeling were ...
Zineddine Zebbiche, Güldeniz Şekerci, Boulebd Houssem, Fatümetüzzehra Küçükbay, Suat Tekin, Hasan Küçükbay, Boudjemaa Boumoud   +6 more
wiley   +2 more sources

Synthesis and Characterization of 1,3,4-Oxadiazoles Derived From 9-Fluorenone

مجلة بغداد للعلوم, 2013
In the present work, 9-fluorenone-2-carboxylic acid methyl ester (1) was prepared from 9-fluorenone-2-carboxylic acid and then converted into the acid hydrazide (2).
Baghdad Science Journal
doaj   +1 more source

Synthesis and Antimicrobial Screening of Some New Thiazole Substituted 1,3,4-Oxadiazole Derivatives

Chemistry Proceedings, 2021
In the present work, the synthesis and antimicrobial activity of new thiazole substituted 1,3,4-oxadiazole derivatives was achieved. The reaction of different thioamides with ethyl 4-chloro-3-oxobutanoate (4-chloro ethyl acetoacetate) provided ethyl 2-(2-
Siddhant V. Kokate, Sachin V. Patil
doaj   +1 more source

Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives

Journal of Advanced Pharmaceutical Technology & Research, 2014
The presence of heterocyclic structures in diverse types of compounds, this is strongly indicative of the profound effect like structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic ...
Dilipkumar Pal, Rohit Tripathi, Desh Deepak Pandey, Preety Mishra   +3 more
doaj   +1 more source

Arylation Reactions in the Synthesis of Biologically Important 2,5-Diaryl-1,3,4-Oxadiazoles

Applied Sciences, 2022
Apart from carbon atoms, some cyclic molecules contain other elements and play an extraordinary role in human life. Among these systems, 1,3,4-oxadiazole derivatives deserve special attention due to their biological properties such as antibacterial ...
Monika Olesiejuk, Agnieszka Kudelko
doaj   +1 more source

Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives

Journal of Saudi Chemical Society, 2014
In the present investigation, a series of 2(4-pyridyl)-5[(aryl/heteroarylamino)-1-oxoethyl]thio-1,3,4-oxadiazole were synthesized using isonicotinohydrazide and substituted aryl/heteroaryl amines using pyridine as solvent.
Jignesh P. Raval, Tarunkumar N. Akhaja, Dhaval M. Jaspara, Kruti N. Myangar, Nilesh H. Patel   +4 more
doaj   +1 more source

Efficient Synthesis of Novel 1,3,4-Oxadiazoles Bearing a 4-N,N-Dimethylaminoquinazoline Scaffold via Palladium-Catalyzed Suzuki Cross-Coupling Reactions

Molecules, 2020
Two series of novel (symmetrical and unsymmetrical) quinazolinylphenyl-1,3,4-oxadiazole derivatives were synthesized using palladium-catalyzed Suzuki cross-coupling reactions. The presented synthetic methodology is based on the use of bromine-substituted
Barbara Wołek, Mateusz Werłos, Magdalena Komander, Agnieszka Kudelko   +3 more
doaj   +1 more source

5-Phenyl-1,3,4-oxadiazol-2-amine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title complex, C(8)H(7)N(3)O, the C-O [1.369 (2) and 1.364 (3) Å] and C=N [1.285 (3) and 1.289 (3) Å] bond lengths in the oxadiazole ring are each almost identical within systematic errors, although different substituents are attached to the ring. The phenyl ring is inclined to the planar oxadiazole ring [r.m.s. deviation 0.002 Å] by 13.42 (18)°.
Man-Man Song, Kong-Li Wu, Lin Zhu, Juan Zheng, Yan Xu   +4 more
openaire   +3 more sources

2,5-Bis(4-methoxyphenyl)-1,3,4-oxadiazole [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
En el compuesto del título, C(16)H(14)N(2)O(3), el anillo de 1,3,4-oxadiazol esencialmente plano [desviación máxima = 0.0021 (11) Å] está inclinado en ángulos diedros de 8.06 (6) y 11.21 (6)° con respecto a los dos anillos de benceno; el ángulo diedro entre los últimos anillos es de 11.66 (5)°.
B. Kalluraya, Hoong-Kun Fun, Nithinchandra, Jia Hao Goh   +3 more
openaire   +3 more sources

Antibacterial Activity and Mechanism of Action of Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties on Rice Bacterial Leaf Blight

Molecules, 2015
In this study, sulfone derivatives containing 1,3,4-oxadiazole moieties indicated good antibacterial activities against rice bacterial leaf blight caused by the pathogen Xanthomonas oryzaepv. pv. oryzae (Xoo).
Li Shi, Pei Li, Wenli Wang, Manni Gao, Zengxue Wu, Xianpeng Song, Deyu Hu   +6 more
doaj   +1 more source