Results 31 to 40 of about 2,500 (166)

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Synthetic marvels in tuberculosis research: An in-depth review of 1,3,4-oxadiazole derivatives as antitubercular agents

European Journal of Medicinal Chemistry Reports
Given the growth in drug-resistant and inactive cases of tuberculosis, it is imperative to develop novel, potent chemicals to treat this deadly illness.
Isha Kapila, Ankita Bharwal, Poonam Sharma, Neeraj Choudhary, Vikrant Abbot   +4 more
doaj   +1 more source

Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

Molecules, 2014
The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as
Mohamed M. El Sadek, Nagwa S. Abd El-Dayem, Seham Y. Hassan, Mohamed A. Mostafa, Galila A. Yacout   +4 more
doaj   +1 more source

A New Class of Benzo[b]Thiophene‐1,3,4‐Oxadizole Bearing 1,2,4‐Oxadiazoles as Potent Antimicrobial Targets: Synthesis, Biological Evaluation, Docking, DFT and ADMET Studies

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala, Janardan Sannapaneni, Phani Raja Kanuparthy, Venkata Ramana Singamaneni, Tejeswara Rao Allaka, Pilli Veera Venkata Nanda Kishore   +5 more
wiley   +1 more source

Designing of Promising VEGFR‐2 Inhibitors by Using QSAR Modeling, Molecular Docking, and Molecular Dynamic Simulation: Implications Toward the Treatment of Cancer

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Background The vascular endothelial growth factor receptor 2 (VEGFR‐2) is considered one of the most studied therapeutic targets for the treatment of various cancers. Among many heterocyclic compounds, the oxadiazole derivatives have been reported to exhibit significant anticancer activities. Therefore, exploring these derivatives against VEGFR‐2 could
Aisha A. Alsfouk, Pervaiz Ali Channar, Muhammad Sajjad Bilal, Syeda Abida Ejaz, Song J. A. Kim, Sohini Basu Roy   +5 more
wiley   +1 more source

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Thiocarbamoylimidates as Precursors of New 5‐Amino‐1,2,4‐Triazole and Oxadiazole Derivatives In Silico Prediction of Absorption, Distribution, Metabolism, and Excretion Parameters

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
1,2,4‐triazole and oxadiazole motifs are synthesized from thiocarbamoylimidates precursors, under mild conditions (40 °C) in the environmentally friendly water/ethanol reaction medium. The reaction is highly versatile and allows for the introduction of a wide variety of functional groups.
Oumaima Gatri, Thierry Roisnel, Marie Cordier, Vincent Dorcet, Mohamed Lotfi Efrit, Cédric Fischmeister   +5 more
wiley   +1 more source

The Identification and synthesis of metabolites of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide

Research Results in Pharmacology
Introduction: 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide is a new selective type II carbonic anhydrase inhibitor with local action through instillation into the eyes. For a complete pharmacokinetic study of this drug, it is necessary to detect
Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Valeria A. Panova, Julia A. Efimova, Sergey A. Ivanovskiy, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov   +8 more
doaj   +1 more source

Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents

E-Journal of Chemistry, 2009
1,3,4-Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4-oxadiazole is popularly known for its antimicrobial, anti-inflammatory, pesticidal and antihypertensive activities etc.
Niti Bhardwaj, S. K. Saraf, Pankaj Sharma, Pradeep Kumar   +3 more
doaj   +1 more source

Synthesis, Characterization of some New 1, 3, 4-Oxadiazole derivatives based on 4- amino benzoic acid

مجلة بغداد للعلوم, 2016
In this research various of 2,5-disubstituted 1,3,4-oxadiazole (Schiff base, oxo-thiazolidine , and other compounds) were synthesized from 2,5-di(4,4?- amino-1,3,4-oxadiazole ) which use quently synthesized from mixture of 4-amino benzoic acid and ...
Baghdad Science Journal
doaj   +1 more source