Results 1 to 10 of about 416,337 (149)

A Convenient Synthesis of Novel Isoxazolidine and Isoxazole Isoquinolinones Fused Hybrids

Molecules, 2023
Isoxazolidine, isoxazole, and isoquinolinone rings are present in the structure of several natural products and/or pharmaceutically interesting compounds.
Konstantinos A. Ouzounthanasis, Stergios R. Rizos, Alexandros E. Koumbis   +2 more
doaj   +1 more source

Additive-assisted regioselective 1,3-dipolar cycloaddition of azomethine ylides with benzylideneacetone

Beilstein Journal of Organic Chemistry, 2014
1,3-Dipolar cycloadditions of isatins, benzylamine and benzylideneacetones were studied to prepare a series of novel spiropyrrolidine-oxindoles – 4′-acetyl-3′,5′-diarylspiro[indoline-3,2′-pyrrolidin]-2-ones and 3′-acetyl-4′,5′-diarylspiro[indoline-3,2 ...
Chuqin Peng, Jiwei Ren, Jun-An Xiao, Honggang Zhang, Hua Yang, Yiming Luo   +5 more
doaj   +1 more source

Enantioselective Cycloaddition Reactions Catalyzed by BINOL-Derived Phosphoric Acids and N-Triflyl Phosphoramides: Recent Advances

Molecules, 2015
Over the last several years there has been a huge increase in the development and applications of new efficient organocatalysts for enantioselective pericyclic reactions, which represent one of the most powerful types of organic transformations.
Felix E. Held, Dominik Grau, Svetlana B. Tsogoeva   +2 more
doaj   +1 more source

Decarboxylation-Driven Double Annulations: Innovative Multi-Component Reaction Pathways

Molecules
A concerted five-component reaction strategy has been developed, featuring double [3+2] cycloadditions utilizing aspartic acid. This approach provides valuable insights into mechanistic pathways, allowing for the distinction between concerted and ...
Desheng Zhan, Gang Yang, Tieli Zhou, Sashirekha Nallapati, Xiaofeng Zhang   +4 more
doaj   +1 more source

A sequential multistep process for the fully mechanochemical, one-pot synthesis of the antiepileptic drug rufinamide

Green Chemistry Letters and Reviews, 2022
Mechanochemistry is a powerful tool to develop environmentally benign syntheses of active pharmaceutical ingredients. In this context, we report here the synthesis of the anti-epileptic agent rufinamide through a one-pot sequential multi-component ...
Jorge Gómez-Carpintero, Clara Cabrero, Juan Domingo Sánchez, Juan Francisco González, José Carlos Menéndez   +4 more
doaj   +1 more source

(SP,SP)-(–)-(E)-1,2-Bis(methylphenylphosphinoyl)ethene

Acta Crystallographica Section E, 2009
The title compound, C16H18O2P2, possesses two stereogenic P atoms and shows a distorted s–cis conformation of each O=P—C=C moiety. This has been suggested on the basis of the stereochemical result of 1,3-dipolar cycloadditions with ...
doaj   +1 more source

Coumarin–Tetrapyrrolic Macrocycle Conjugates: Synthesis and Applications

Molecules, 2017
This review covers the synthesis of coumarin–porphyrin, coumarin–phthalocyanine and coumarin–corrole conjugates and their potential applications. While coumarin–phthalocyanine conjugates were obtained almost exclusively by tetramerization of coumarin ...
Ana F. R. Cerqueira, Vítor A. S. Almodôvar, Maria G. P. M. S. Neves, Augusto C. Tomé   +3 more
doaj   +1 more source

Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity

Molecules, 2023
Multicomponent reactions (MCRs) have undoubtedly emerged as the most indispensable tool for organic chemists worldwide, finding extensive utility in the synthesis of intricate natural products, heterocyclic molecules with significant bioactivity, and ...
Hua Zhao, Yufen Zhao
doaj   +1 more source

Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones}

Beilstein Journal of Organic Chemistry, 2008
Oxazolo[5,4-d]pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives.
Subrata Mandal, Wen Tai Li, Yan Bai, Jon D. Robertus, Sean M. Kerwin   +4 more
doaj   +1 more source

Synthesis and cytotoxic evaluation of substituted 3-(3′-indolyl-/3′-pyridyl)-isoxazolidines and bis-indoles

Acta Pharmaceutica Sinica B, 2012
Regio- and stereoselective 1,3-dipolar cycloadditions of C-(3-indolyl)-N-phenylnitrone (10) were carried out with different mono-substituted, disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation to obtain substituted 3-(indol-3 ...
Vishal Sharma, Raman Kalia, Tilak Raj, Vivek K. Gupta, Nitasha Suri, Ajit K. Saxena, Deepak Sharma, Surinderjit S. Bhella, Gurpinder Singh, Mohan Paul S. Ishar   +9 more
doaj   +1 more source