Results 11 to 20 of about 231,579 (192)
Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-Benzodiazepines [PDF]
Molecules, 2014 The coupling of proline- and azetidinone-substituted alkenes to 2-azidobenzoic and 2-azidobenzenesulfonic acid gives precursors that undergo intramolecular azide to alkene 1,3-dipolar cycloadditions to give imine-, triazoline- or aziridine-containing ...
Karl Hemming +3 more
doaj +2 more sources
1,3-Dipolar cycloadditions of azomethine imines [PDF]
Organic & Biomolecular Chemistry, 2015 Azomethine imines react with alkenes and alkynes to give pyrazolines, pyrazolidines, pyrazolopyridines, indazoloisoquinolines, pyrazolo[1,5- a ]isoquinolines and pyrazolopyrazolones through regio-, stereo- and enantioselective 1,3-dipolar cycloadditions.
Nájera, Carmen +2 more
openaire +5 more sources
Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions. [PDF]
Angew Chem Int Ed Engl, 2021 In dynamic covalent chemistry, reactions follow a thermodynamically controlled pathway through equilibria. Reversible covalent-bond formation and breaking in a dynamic process enables the interconversion of products formed under kinetic control to ...
Yildirim O +5 more
europepmc +2 more sources
Photo-Triggered, Fast, and Fluorogenic Thiophene-Based Cycloalkynes for the Bioorthogonal Fluorescent Labeling of 1,3-Dipole-Tagged Molecules in No-Wash Conditions. [PDF]
Angew Chem Int Ed EnglThiophene is king! The fusion of thiophene rings to cycloalkynes super‐charged their copper‐free click chemistry applications, by (1) enhancing the alkyne reactivity (fastest cyclooctyne to date) and (2) rendering the alkyne fluorogenic (with fluorescence enhancement up to 150‐fold upon reaction), making these bioorthogonal reagents ideal for tracking ...
Schulz J +7 more
europepmc +3 more sources
1,3-Dipolar Cycloadditions of Diazo Compounds in the Presence of Azides. [PDF]
Org Lett, 2016 The diazo group has untapped utility in chemical biology. The tolerance of stabilized diazo groups to cellular metabolism is comparable to that of azido groups. However, chemoselectivity has been elusive, as both groups undergo 1,3-dipolar cycloadditions
Aronoff MR, Gold B, Raines RT.
europepmc +2 more sources
, 2016 Intramolecular cycloadditions with high regio- and stereocontrol are important methods for the efficient assembly of complex molecular structures. Efficient routes to the synthesis of norbornadiene-tethered nitrile oxides have been developed, and their ...
Robert Jordan (346146) +3 more
core +9 more sources
Exploring strain-promoted 1,3-dipolar cycloadditions of end functionalized polymers. [PDF]
Chemistry, 2014 Strain-promoted 1,3-dipolar cycloaddition of cyclooctynes with 1,3-dipoles such as azides, nitrones, and nitrile oxides, are of interest for the functionalization of polymers.
Ledin PA +3 more
europepmc +3 more sources
Kinetic solvent effects on 1,3-dipolar cycloadditions of benzonitrile oxide [PDF]
, 2005 The kinetics of 1,3-dipolar cycloadditions of benzonitrile oxide with a series of N-substituted maleimides and with cyclopentene are reported for water, a wide range of organic solvents and binary solvent mixtures.
Jan B. F. N. Engberts +5 more
core +2 more sources
Intramolecular Cycloaddition of Imines of Cysteine Derivatives
Molecules, 1998 Azomethine ylides were generated from Schiffs bases of S-allylcysteine methyl ester and their intramolecular 1,3-dipolar cycloadditions were studied. These reactions led to the synthesis of thieno[3,4-b]pyrrole derivatives in good yield.
Teresa M. V. D. Pinho e Melo +2 more
doaj +1 more source
Molecules, 2016 We provide a comprehensive account of the 1,3-dipolar cycloaddition reactions of azomethine ylides with carbonyl dipolarophiles. Many different azomethine ylides have been studied, including stabilized and non-stabilized ylides.
Adam G. Meyer, John H. Ryan
doaj +1 more source