Results 41 to 50 of about 1,389 (161)

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, EarlyView.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source

Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis

Chemistry – A European Journal, EarlyView.
Mechanochemistry offers a sustainable, solvent‐free alternative to traditional synthesis, often enhanced by additives in a process known as additive‐assisted grinding. This review discusses how various additives, including liquids, ionic solids, and advanced materials like ionic liquids and piezoelectric compounds, improve reaction efficiency ...
Johanna Breinsperger, Nika Podlesnik, Francesco Mele, Michael Schnürch   +3 more
wiley   +1 more source

B‐N Fused Anthracene as Functional Linker for π‐Extended Viologens: Near‐IR Emission and Electrochromism

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
We introduce π–extended viologens with B‐N fused dipyridylanthracene (BDPA) as conduit for delocalization. Quaternization of pyridyl‐substituted BDPA by methylation or Lewis pair formation with B(C6F5)3 produces strongly colored compounds that are emissive in the near‐IR.
Rajendra Prasad Nandi, Jingyao Zuo, Abhishek Shibu, Frieder Jäkle   +3 more
wiley   +2 more sources

Synthesis and cytotoxic evaluation of substituted 3-(3′-indolyl-/3′-pyridyl)-isoxazolidines and bis-indoles

Acta Pharmaceutica Sinica B, 2012
Regio- and stereoselective 1,3-dipolar cycloadditions of C-(3-indolyl)-N-phenylnitrone (10) were carried out with different mono-substituted, disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation to obtain substituted 3-(indol-3 ...
Vishal Sharma, Raman Kalia, Tilak Raj, Vivek K. Gupta, Nitasha Suri, Ajit K. Saxena, Deepak Sharma, Surinderjit S. Bhella, Gurpinder Singh, Mohan Paul S. Ishar   +9 more
doaj   +1 more source

Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity

Molecules, 2023
Multicomponent reactions (MCRs) have undoubtedly emerged as the most indispensable tool for organic chemists worldwide, finding extensive utility in the synthesis of intricate natural products, heterocyclic molecules with significant bioactivity, and ...
Hua Zhao, Yufen Zhao
doaj   +1 more source

A Tandem Chemical Vapor Deposition Platform for the Solvent‐Free Synthesis of Polypeptide Architectures

Chemistry – A European Journal, EarlyView.
A solvent‐free, two‐step chemical vapor polymerization enables efficient, substrate‐independent synthesis of surface‐attached polypeptide films. Initiator deposition via CVD is followed by NCA ring‐opening polymerization. Characterization confirms film formation and functionalization, allowing precise micropatterning and bioactive surface design for ...
Domenic Kratzer, Martina Plank, Meike Koenig, Tahereh Mohammadi Hafshejani, Joerg Lahann   +4 more
wiley   +1 more source

Bifunctional Molecular Switches in Fused Diarylethene–Rhodamine Systems

ChemPhotoChem, EarlyView.
Spectroscopic and time‐dependent density‐functional theory studies show that these novel rhodamine‐based diarylethene (DAE) compounds display intense UV absorption, undergo reversible two‐step protonation involving triazole and rhodamine units, and respond selectively to acid, base, and metal ions.
Bassima Hoteit, Shunan Zhao, Corentin Poidevin, Arnaud Fihey, Keith Man‐Chung Wong, Julien Boixel   +5 more
wiley   +1 more source

Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones}

Beilstein Journal of Organic Chemistry, 2008
Oxazolo[5,4-d]pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives.
Subrata Mandal, Wen Tai Li, Yan Bai, Jon D. Robertus, Sean M. Kerwin   +4 more
doaj   +1 more source

Reversible Nanocomposites With Carbon Nanotubes as the Diene in the Diels–Alder Reaction

Polymer Composites, EarlyView.
Scheme of the reversible nanocomposites through DA and rDA reactions with participation of carbon nanotubes. ABSTRACT Carbon nanotubes (CNTs) often require surface functionalization to facilitate uniform distribution and address issues related to aggregation. Due to the sp2 hybridized carbon atoms on their surface, CNTs readily participate in the Diels–
Jie Guo, Nick van der Ploeg, Muhammad Nabil Bin Mubarak Shah, Ranjita K. Bose   +3 more
wiley   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source