Results 91 to 100 of about 235,743 (243)

Recent Advances in Ene Reactions with Carbon Enophiles

Advanced Synthesis &Catalysis, Volume 367, Issue 22, November 28, 2025.
Recent advances in the classical intra‐ and intermolecular ene nexus with carbon enophiles (alkenes, alkynes, arynes, and allenes) show a considerable increase in structural complexity and an enormous potential for functional applications in polymer science.
Thomas J. J. Müller
wiley   +1 more source

Дилудин и цереброкраст как биопротекторы в модельных тест-системах in vivo [PDF]

, 2009
Изучено влияние двух производных 1,4-дигидропиридина — дилудина и цереброкраста — на развитие дрозофилы и мутабильность половых клеток. Выявлен диапазон доз, в котором препараты проявляют биостимулирующие эффекты, повышая на 50–80 % выживаемость особей ...
Даливеля, Ольга Вячеславовна
core  

Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]

, 2013
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Cencioni, Chiara, Gaetano, Carlo, Mai, Antonello, Martelli, Fabio, Spallotta, Francesco, Valente, Sergio, Zeiher, Andreas Michael   +6 more
core   +2 more sources

Enantioselective Desymmetrization by Chiral Bifunctional H‐Bonding Organocatalysts

Chemistry – A European Journal, Volume 31, Issue 61, November 3, 2025.
Enantioselective desymmetrization has emerged as a highly efficient and conceptually elegant strategy for the construction of chiral molecules from readily available prochiral substrates. This review focuses on recent developments in organocatalytic desymmetrization reactions, with particular emphasis on approaches involving bifunctional activation ...
Michal Urban, Jan Veselý
wiley   +1 more source

b-Annulated 1,4-dihydropyridines as Notch inhibitors

Bioorganic & Medicinal Chemistry Letters, 2018
The Notch signaling pathway is involved in cell proliferation and differentiation, and has been recognized as an active pathway in regenerating tissue and cancerous cells. Notch signaling inhibition is considered a viable approach to the treatment of a variety of conditions including colorectal cancer, pancreatic cancer, breast cancer and metastatic ...
Jorge E, Gómez-Galeno, Cecilia, Hurtado, Jiongjia, Cheng, Ceren, Yardimci, Mark, Mercola, John R, Cashman   +5 more
openaire   +3 more sources

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

Catalytic Asymmetric Synthesis of Both Enantiomers of 4‑Substituted 1,4-Dihydropyridines with the Use of Bifunctional Thiourea-Ammonium Salts Bearing Different Counterions

Molecules, 2010
Organoammonium salts composed of a Brønsted acid and an anilinothiourea promoted the Michael addition of β-keto esters and α,β-unsaturated aldehydes in the presence of primary amines to give functionalized 1,4-dihydropyridines enantioselectively.
Kohzo Yoshida, Tsubasa Inokuma, Kiyosei Takasu, Yoshiji Takemoto   +3 more
doaj   +1 more source

Synthesis and reactivity of N-alkyl-2-oxoalkanesulfonamides [PDF]

, 1998
A series of N-alkyl-2-oxoalkanesulfonamides have been synthesized by reacting silyl enol ethers with N-alkyl-sulfamoyl chlorides. Their reactivity towards electrophiles was investigated in order to explore the regio-and stereoselectivity of the process ...
Alajarín Ferrández, Ramón, Vaquero López, Juan José, Vega Ramiro, Juan Antonio, Álvarez-Builla Gómez, Julio   +3 more
core   +3 more sources

Synthesis and characterization of a novel series of 1,4‐dihydropyridine analogues for larvicidal activity against Anopheles arabiensis

Chemical Biology and Drug Design, 2017
The new‐fangled bis(4‐substituted benzyl) 4‐(4‐substitued phenyl)‐2,6‐dimethyl‐1,4‐dihydropyridine‐3,5‐dicarboxylate derivatives were synthesized by the union of substituted aryl aldehyde, tert‐butyl acetoacetate, ammonium carbonate with 4‐substituted ...
Bhaskara D Dharma Rao, S. Bhandary, D. Chopra, Katharigatta N. Venugopala, R. M. Gleiser, K. Kasumbwe, B. Odhav   +6 more
semanticscholar   +1 more source

Synthesis of Novel Dihydropyridine‐Iminium Salts Containing a Selenazine Core

Asian Journal of Organic Chemistry, Volume 14, Issue 10, October 2025.
An efficient method to develop novel dihydropyrido[3,2‐e][1,3]selenazines iminium salts. A comparative study of the key reagent selenourea towards thiourea and urea was carried out to assess the contribution of chalcogen to the pathway. DFT (density functional theory) calculations have predicted the optimized minimum energy structure for the hybrid ...
Reinier Lemos, Mauro De Nisco, Yoana Pérez‐Badell, Gabriella Pinto, Marco Morelli, Margarita Suárez, Silvana Pedatella   +6 more
wiley   +1 more source