Results 151 to 160 of about 146,224 (211)

Solid state photochemistry of 1,4-dihydropyridines

Bioorganic and Medicinal Chemistry Letters, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Arsalan Mirjafari, Hamid Reza Memarian
exaly   +3 more sources

Synthesis of Some New Unsymmetrically Substituted 1,4-Dihydropyridines

Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences, 2006
A series of some new 3,5-unsymmetrically substituted 1,4-dihydropyridines have been synthesized, which have ethoxycarbonyl and acetyl groups on 3-and 5-positions, respectively. A three-step procedure has been examined to increase the yield of the desired
Masumeh Abdoli-Senejani, Hamid Reza Memarian, Dietrich Döpp   +2 more
exaly   +1 more source

Coumarin 1,4-Dihydropyridine Derivatives

Bioorganic & Medicinal Chemistry, 1998
A series of 1,4-dihydropyridines bearing a coumarin moiety in 4-position was synthesized. The compounds were evaluated for inotropic, chronotropic and calcium antagonist activities. The replacement of the o-nitrophenyl moiety of nifedipine with a coumarin or phenylcoumarin system is accompanied by a decrease of the activity on myocardial and vascular ...
Valenti P., Rampa A., Budriesi R., Bisi A., Chiarini A.   +4 more
openaire   +2 more sources

Iodocyclization of 1,4-dihydropyridines

Tetrahedron Letters, 1998
Abstract Iodine (or related species) addition to 1,4-dihydropyridines, with properly attached substituents at the nitrogen atom, leads to the corresponding 3-iodotetrahydropyridinium ions, which undergo an internal nucleophilic attack to furnish regio- and stereoselectively iodobi(poly)lteterocyclic ring systems in good yields.
Rodolfo Lavilla, Oscar Coll, Marta Nicolàs, Joan Bosch   +3 more
openaire   +1 more source

The oxidation of 1,4-dihydropyridines

Chemistry of Heterocyclic Compounds, 1970
The olefinic bond of methenylbisindan-1,3-dione, 2-benzylideneindan-1, 3-dione, and its derivatives is easily reduced by many 1, 4-dihydropyridines. Under the conditions described, other functional groups are untouched. These Β-dicarbonyl compounds are utilized to compare the effects of substituents in 1,4-dihydropyridines on their reactivity in the ...
G. Ya. Dubur, Ya. R. Uldrikis
openaire   +1 more source

1,4-Dihydropyridines and the 1,4-Dihydropyridine Receptor

1993
The 1,4-dihydropyridine nifedipine is a first-generation drug of major significance in the treatment of cardiovascular disorders including hypertension, peripheral vascular disorders and angina in its several forms. Nifedipine is one of a chemically and pharmacologically heterogeneous group of drugs that includes also verapamil and diltiazem and which ...
openaire   +1 more source

Aromatization of 1,4‐Dihydropyridines with Selenium Dioxide.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiao-hua Cai, Hai-jun Yang, Guo-lin Zhang   +2 more
openaire   +1 more source

The photochemistry of 3,5-disubstituted 1,4-dihydropyridines

Tetrahedron, 1970
Abstract On irradiation, 1,4-dihydropyridines have been shown to undergo three types of reaction: disproportionation, isomerization and dimerization. The presence of 2,6-substituents inhibits these reactions except in the case of 3a which undergoes disproportionation.
U, Eisner, J R, Williams, B W, Matthews, H, Ziffer   +3 more
openaire   +2 more sources

1,4-Dihydropyridine activators in the tiamdipine series

European Journal of Pharmacology, 1990
The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carbomethoxy-5-carbomethoxy-6-m ethyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart.
GALLETTI, FERRUCCIO, Luchowski E, Triggle DJ   +2 more
openaire   +3 more sources

The 1,4-Dihydropyridine Receptor

Journal of Cardiovascular Pharmacology, 1984
Evidence that nitrendipine (2,6-dimethyl-3-carbomethoxy-5-carbomethoxy-4-(3-nitrophenyl)1,4- dihydropyridine) and other 1,4-dihydropyridines interact at a specific site to antagonize Ca2+ channel function is reviewed. This evidence derives from electrophysiologic and pharmacologic studies and is confirmed by [3H]radioligand binding to excitable tissues.
D J, Triggle, R A, Janis
openaire   +2 more sources