Results 171 to 180 of about 116,777 (208)

Vicinal diamination of 1,4-dihydropyridines

Chemical Communications, 1998
Electrophilic interaction of iodine with N-alkyl-1,4-dihydropyridines 1 in the presence of secondary amines stereoselectively leads to the corresponding trans-2,3-diamino-1,2,3,4-tetrahydropyridines 2 in satisfactory yields (79–94%); the method allows the synthesis of piperidine, pyrrolidine, morpholine and piperazine derivatives.
Rodolfo Lavilla, Rakesh Kumar, Oscar Coll, Carme Masdeu, Joan Bosch   +4 more
openaire   +1 more source

1,4-Dihydropyridines and the 1,4-Dihydropyridine Receptor

1993
The 1,4-dihydropyridine nifedipine is a first-generation drug of major significance in the treatment of cardiovascular disorders including hypertension, peripheral vascular disorders and angina in its several forms. Nifedipine is one of a chemically and pharmacologically heterogeneous group of drugs that includes also verapamil and diltiazem and which ...
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Metalation of 1,4-dihydropyridine esters

Tetrahedron Letters, 1989
Abstract 4-Aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic esters are metalated at the NH and the C-2 methyl positions via tretament with two equivalents of n-butyl lithium. The resulting dilithio species can be treated with a variety of electrophiles to furnish C-2 methyl functionalized dihydropyridine esters.
Graham S. Poindexter, Michael A. Foley, Joseph F. Licause   +2 more
openaire   +1 more source

Fluorine-containing 1,4-dihydropyridines

Journal of Fluorine Chemistry, 1996
Abstract A series of 1,4-dihydropyridines with fluorine-containing substituents of various electronic nature and lipophilicity, as synthesized in our Department, are considered and their biological activity as calcium channels modulators is discussed.
L.M. Yagupolskii, I.I. Maletina, K.I. Petko, D.V. Fedyuk   +3 more
openaire   +1 more source

The alkylation of hantzsch 1,4‐dihydropyridines

Journal of Heterocyclic Chemistry, 1986
AbstractThe reaction of carbanions derived from Hantzsch 1,4‐dihydropyridines with alkyl halides was studied and methods for mono‐ and di‐alkylation were devised.
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Probing the mechanism of SIRT1 activation by a 1,4-dihydropyridine

Journal of Molecular Modeling, 2018
The NAD+-dependent deacetylase SIRT1 plays important roles in several physiological processes such as transcription, genome stability, stress responses, and aging. Due to its diverse role in metabolisms, SIRT1 has emerged as a potential therapeutic target in many human disorders such as type II diabetes, cardiovascular and neurodegenerative diseases ...
Debashri, Manna, Rajabrata, Bhuyan, Rita, Ghosh   +2 more
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Syntheses of Pyrrolo‐ and Furo‐1,4‐dihydropyridine Derivatives.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Keizo Matsuo, Masami Adachi, Tatsuko Takagi, Sachiko Ueno, Takahiko Arase, Fumie Kuroi   +5 more
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Synthesis of Novel Asymmetrical 1,4‐Dihydropyridine Derivatives.

ChemInform, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Adeleh Moshtaghi Zenouz, Mina Raisossadat Oskuie, Shirin Mollazadeh   +2 more
openaire   +1 more source

Synthesis of 3-amino-1,4-dihydropyridine derivativevia an intramolecular rearrangement of 1,4-dihydropyridine-3-hydroxamate

Archives of Pharmacal Research, 1991
2,6-Dimethyl-4-(3′-nitrophenyl)-3-methoxylaminocarbonyl-1,4-dihydropyridine-5-carboxylic acid methylester,3b reacted with 2-cyanoethanol or benzylalcohol to give the corresponding cyanoethylurethane compound6c in 40.6% yield and benzylurethane compound6d in 32% yield.
Jung Jin Suh, You Hwa Hong, Myn Bae
openaire   +1 more source

Photoelectron spectra of 1,4-dihydropyridine and N-methyl-1,4-dihydropyridine

The Journal of Organic Chemistry, 1974
T. Koenig, H. Longmaid
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