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Synthesis of Bis‐1,4‐dihydropyridine Derivatives.
ChemInform, 2005Abstract A series of bis‐1,4‐dihydropyridine derivatives were synthesized by the reaction of p‐phenylenedialdehyde or m‐phenylenedialdehyde and active methylene compounds.
Songlei Zhu +7 more
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Cocrystals of diastereoisomers of 1,4-dihydropyridine derivatives
Acta Crystallographica Section C Crystal Structure Communications, 2006A mixture of the RR/SS and RS/SR diastereoisomeric pairs of methyl 4-(2,4-dichlorophenyl)-2,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C 19 H 19 Cl 2 NO 3 , forms cocrystals in which there is one unique molecule in the asymmetric unit, but the molecule displays disorder in the region of the 7-position of the quinoline ring system as
Linden A +3 more
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Aromatization of 1,4‐Dihydropyridines with Selenium Dioxide.
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiao-hua Cai +2 more
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Photoprotection of 1,4-dihydropyridine derivatives by dyes
International Journal of Pharmaceutics, 2005The possibility of increasing the photochemical stability of nisoldipine by using indigotine and azorubine as photoprotectors has been studied. The course of the photodegradation was monitored by means of UV-vis spectrophotometry and HPLC. Quantitative assessments of the nisoldipine photodegradation included evaluation of the quantum yields and kinetic
Jadwiga, Mielcarek +3 more
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The 1,4-Dihydropyridine Receptor
Journal of Cardiovascular Pharmacology, 1984Evidence that nitrendipine (2,6-dimethyl-3-carbomethoxy-5-carbomethoxy-4-(3-nitrophenyl)1,4- dihydropyridine) and other 1,4-dihydropyridines interact at a specific site to antagonize Ca2+ channel function is reviewed. This evidence derives from electrophysiologic and pharmacologic studies and is confirmed by [3H]radioligand binding to excitable tissues.
D J, Triggle, R A, Janis
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1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine
Bioorganic & Medicinal Chemistry, 1996A series of 1,4-dihydropyridines bearing a pharmacophoric fragment of lidoflazine was synthesized. The compounds were evaluated for inotropic, chronotropic, and calcium antagonist activities. All compounds behave as inotropic and chronotropic agents, except for compounds 4b, 5a, and 5b, which exhibit a rather weak calcium antagonism in vascular smooth ...
Chiarini A. +5 more
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A new synthesis of 1,4-dihydropyridines
Journal of the Chemical Society, Perkin Transactions 1, 1975The synthesis of 1,4-dihydropyridines unsubstituted in the 1-, 2-, and 6-positions from methyl propiolate, aromatic aldehydes, and ammonium acetate in acetic acid is described. The products were oxidised to the corresponding pyridines. Certain features of their n.m.r. spectra are discussed.
Tomy Chennat, Ulli Eisner
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Construction of 1,4-Dihydropyridines: The Evolution of C4 Source
Topics in Current Chemistry, 2023The field of cascade cyclization for the construction of 1,4-dihydropyridines (1,4-DHPs) has been continuously expanding during the last decades because of their broad-spectrum biological and synthetic importance. To date, many methods have been developed, mainly including the Hantzsch reaction, Hantzsch-like reaction and newly developed cascade ...
Siyu, Song, Yongchao, Wang, Fuchao, Yu
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Novel fluorescent 1,4-dihydropyridines
Journal of the American Chemical Society, 1986Etude de la reaction modele de formation d'α-alkyl alkyl-4 diformyl-3,5 dihydro-1,4 pyridineacetates-1 a partir de propanedial, d'alcanals et d'α ...
Vasu. Nair +2 more
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Reactions of 1,4-dihydropyridines (review)
Chemistry of Heterocyclic Compounds, 1993The literature published over the period 1986–1990 on the chemical properties (oxidation, addition, substitution, reactions of the functional groups, etc.) of 1,4-dihydropyridines is correlated.
A. Sausin'sh, G. Dubur
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