Results 101 to 110 of about 62,864,054 (165)

1α,25-dihydroxyvitamin D3 Attenuates TGF-β-Induced Pro-Fibrotic Effects in Human Lung Epithelial Cells through Inhibition of Epithelial–Mesenchymal Transition

, 2017
Pulmonary fibrosis is a progressive fibrotic lung disease of persisting lung injury and ineffective wound repair, with poor prognosis. Epithelial–mesenchymal transition (EMT) of alveolar epithelia cells is an early event in the development of pulmonary ...
Bingyan Li, Yong Yang, Lian Xue, Zengli Zhang, Fei Jiang   +4 more
core   +1 more source

Vitamin D3 promotes white fat beige through IL-27/P38MAPK/PGC-1α pathway

Frontiers in Nutrition
BackgroundObesity is turning into a more critical problem for public health. Vitamin D3 (VD3) may be strongly linked to obesity.ObjectivesThe study aims to examine the influence of VD3 on IL-27 levels and the molecular mechanism by which VD3 affects ...
Yanqiu Zhou, Yanqiu Zhou, Junfang Shu, Yueying Zhao, Xiaorong Wu, Zhijun He, Xinzhe Lyu, Yong Zhou, Ling Ma, Ling Ma   +9 more
doaj   +1 more source

1α,25(OH)2-Vitamin D3 stimulates intestinal cell p38 MAPK activity and increases c-Fos expression

, 2006
In intestinal cells, as in other target cells, the steroid hormone 1α,25(OH)2-Vitamin D3 (1α,25(OH)2D3) regulates gene expression via the specific intracellular Vitamin D receptor and induces fast non-transcriptional responses involving stimulation of ...
González Pardo, María Verónica, Boland, Ricardo Leopoldo, Russo, Ana Josefa   +2 more
core   +1 more source

1α,25-Dihydroxyvitamin D3 reduces uropathogenic E. coli persistence in bladder epithelial cells by restoring lysosome acidification

Bangladesh Journal of Pharmacology
This study aimed to examine the effect of 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the intracellular persistence of uropathogenic Escherichia coli. After establishing a cell infection model and conducting drug intervention, methods such as fluorescent
Hao Yin, Yi Xue, Xin Wang
doaj   +1 more source

Genetic signatures of differentiation Induced by 1α ,25-Dihydroxyvitamin D3 in human colon cancer cells

, 2013
Epidemiological and preclinical data indicate that vitamin D and its most active metabolite 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] have anticancer activity.
Pálmer, Héctor G., Ordóñez-Morán, Paloma, Muñoz Terol, Alberto, Larriba, María Jesús   +3 more
core  

A Concise and Efficient Route to 2α-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D₃:  Remarkably High Affinity to Vitamin D Receptor¹

, 2016
A convenient and potentially valuable synthetic approach to the novel 2α-functionalized 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] derivatives (1a−c), which are the C2-epimer of ED-71 and its analogues, has been developed.
Yoshitomo Suhara (616017), Toshie Fujishima (2530501), Atsushi Kittaka (1937032), Hitoshi Takayanagi (2703928), Masaaki Kurihara (1407931), Hiroaki Takayama (2530507)   +5 more
core   +1 more source

Calcitriol Treatment Decreases Cell Migration, Viability and β-Catenin Signaling in Oral Dysplasia

Current Issues in Molecular Biology
Nearly 90% of oral cancers are characterized as oral squamous cell carcinoma (OSCC), representing the sixth most common type of cancer. OSCC usually evolves from oral potentially malignant disorders that, in some cases, are histologically consistent with
Daniel Peña-Oyarzún, Constanza Guzmán, Catalina Kretschmar, Vicente A. Torres, Andrea Maturana-Ramirez, Juan Aitken, Montserrat Reyes   +6 more
doaj   +1 more source

The Vitamin D Receptor in Osteoblast-Lineage Cells Is Essential for the Proresorptive Activity of 1α,25(OH)2D3 In Vivo.

Endocrinology, 2020
Mori T, Horibe K, Koide M, Uehara S, Yamamoto Y, Kato S, Yasuda H, Takahashi N, Udagawa N, Nakamichi Y.   +9 more
europepmc   +1 more source

Functional studies of the human 25-hydroxyvitamin D3-24-hydroxylase, CYP24A1 [PDF]

, 2015
Thesis (Ph.D, Biochemistry) -- Queen's University, 2010-06-07 14:46:40.409This thesis focuses on the cytochrome P450 CYP24A1, which catabolizes 1α,25-dihydroxyvitamin D3 (1α,25-(OH)2D3) via two pathways commencing with C24-, or C23-hydroxylation and
Kaufmann, Martin
core  

The Influence of 1α.25-Dihydroxyvitamin D3 Coating on Implant Osseointegration in the Rabbit Tibia

eJournal of Oral Maxillofacial Research, 2014
Objectives: This study aims to evaluate bone response to an implant surface modified by 1α,25-dihydroxyvitamin D3 [1.25-(OH)2D3] in vivo and the potential link between 1.25-(OH) 2D3 surface concentration and bone response. Material and Methods: Twenty-
Yoshihito, Ryo, Matthew S., Stefan, Bruno R., Nick, Tetsuo, Paulo G., Ann   +8 more
doaj