Results 91 to 100 of about 62,864,054 (165)

1α,25(OH)₂D₃ Promotes the Autophagy of Porcine Ovarian Granulosa Cells as a Protective Mechanism against ROS through the BNIP3/PINK1 Pathway. [PDF]

Int J Mol Sci, 2023
Wang S, Yao Q, Zhao F, Cui W, Price CA, Wang Y, Lv J, Tang H, Jiang Z.   +8 more
europepmc   +1 more source

MAP kinases p38 and JNK are activated by the steroid hormone 1α,25(OH)2-vitamin D3 in the C2C12 muscle cell line [PDF]

, 2006
In chick skeletal muscle cell primary cultures, we previously demonstrated that 1α,25(OH)2-vitamin D3 [1α,25(OH) 2D3], the hormonally active form of vitamin D, increases the phosphorylation and activity of the extracellular signal-regulated mitogen ...
Boland, Ricardo Leopoldo, Ronda, Ana Carolina, Russo, Ana Josefa, Buitrago, Claudia Graciela   +3 more
core   +1 more source

1α,25-Dihydroxyvitamin D3 inhibits β-catenin transcriptional activity in human colon cancer cell line SW480 [PDF]

Jichu yixue yu linchuang, 2020
Objective To explore the inhibitory effect and mechanism of 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3]on β-catenin transcriptional activity in human colon cancer cells. Methods Colon cancer cell line SW480 was treated with either 1,25(OH)2D3 (100 nmol/L)
XIN Yu, HE Long-mei, YANG Hong, LYU Hong, TAN Bei, WANG Hong-ying, QIAN Jia-ming
doaj  

Essential roles of Pdia3/PLAA receptor complex and CaMKII IN 1α,25(OH)₂D₃ and Wnt5a calcium-dependent signaling pathways in osteoblasts and chondrocytes

, 2015
The vitamin D metabolite 1,25-dihydroxyvitamin D3 [1α,25(OH)2D3] plays an important role in the regulation of musculoskeletal growth and differentiation.
Doroudi, Maryam
core  

The Role of Galectin-3 in 1α,25(OH)₂D₃-Regulated Osteoclast Formation from White Leghorn Chickens In Vitro. [PDF]

Vet Sci, 2021
Gu J, Min W, Zhao Y, Zhang X, Yuan Y, Liu X, Bian J, Tong X, Liu Z.   +8 more
europepmc   +1 more source

Caveolae and caveolin-1 are implicated in 1α,25(OH)2-vitamin D3-dependent modulation of Src, MAPK cascades and VDR localization in skeletal muscle cells [PDF]

, 2010
We previously reported that 1α,25(OH)2D3 induces non-transcriptional rapid responses through activation of MAPKs in C2C12 skeletal muscle cells. However, there is little information on the molecular mechanism underlying the initiation of 1α,25(OH)2D3 ...
Boland, Ricardo Leopoldo, Buitrago, Claudia Graciela, Ricardo Boland, Claudia Buitrago   +3 more
core   +1 more source

Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents [PDF]

, 2017
Rheumatoid arthritis (RA) is one of the autoimmune diseases, and is affecting 2.5 million Americans in total. Among the treatment options of RA, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] is the only steroidal drug used clinically for anti-inflammatory and ...
Lin, Zongtao
core   +1 more source

Structure−Function Relationships and Crystal Structures of the Vitamin D Receptor Bound 2α-Methyl-(20S,23S)- and 2α-Methyl-(20S,23R)-epoxymethano-1α,25-dihydroxyvitamin D₃

, 2016
The vitamin D nuclear receptor is a ligand-dependent transcription factor that controls multiple biological responses such as cell proliferation, immune responses, and bone mineralization.
Rita Sigüeiro (1991680), Tiphaine Huet (236522), Luis Cezar Rodrigues (2319424), Antonio Mouriño (1451062), Pierre Antony (43999), Nick Ramalanjaona (7363), Dino Moras (2787), Natacha Rochel (225991), Yoshiteru Sato (225974)   +8 more
core   +1 more source

1,25-Dihydroxyvitamin D3 enhances NK susceptibility of human melanoma cells via Hsp60-mediated FAS expression

, 2011
The active metabolite of vitamin D3, 1α,25(OH)2D3, displays anticancer effects by regulating cell cycle and apoptosis in many cancer cells. However, it has not been determined whether 1α,25(OH)2D3 increases the susceptibility of cancer cells to NK cells.
J H Lee, Suk Ran Yoon, T S Kim, S I Bang, S Cheon, S Kim, H T Lee, D Cho, Y Yang, H Park, D Y Hur, S Park   +11 more
core   +1 more source

Effects and interactions of 24R,25(OH)2D3 and 1,25(OH)2D3 on bone

, 1980
The effects of various combinations of therapy with 1 alpha,25-dihydroxycholecalciferol (1,25(OH)2D3) and 24R,25-dihydroxycholecalciferol (24R,25(OH)2D3) on structural and dynamic parameters of bone were evaluated in 40 chicks raised on a vitamin D ...
H. H. Malluche, A. W. Norman, S. G. Massry, D. Sherman, H. Henry, W. Meyer-Sabellak   +5 more
core   +1 more source