Results 71 to 80 of about 62,864,054 (165)

25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression.

PLoS ONE, 2017
Age-associated decline in muscle function represents a significant public health burden. Vitamin D-deficiency is also prevalent in aging subjects, and has been linked to loss of muscle mass and strength (sarcopenia), but the precise role of specific ...
Zaki K Hassan-Smith, Carl Jenkinson, David J Smith, Ivan Hernandez, Stuart A Morgan, Nicola J Crabtree, Neil J Gittoes, Brian G Keevil, Paul M Stewart, Martin Hewison   +9 more
doaj   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Induced differentiation of human myeloid leukemia cells into M2 macrophages by combined treatment with retinoic acid and 1α,25-dihydroxyvitamin D3. [PDF]

PLoS ONE, 2014
Retinoids and 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) induce differentiation of myeloid leukemia cells into granulocyte and macrophage lineages, respectively.
Hiromichi Takahashi, Yoshihiro Hatta, Noriyoshi Iriyama, Yuichiro Hasegawa, Hikaru Uchida, Masaru Nakagawa, Makoto Makishima, Jin Takeuchi, Masami Takei   +8 more
doaj   +1 more source

Mesenchymal Stromal Cell Rejuvenation Strategies to Enhance Clinical Translation in Cell Therapy

Aging Cell, Volume 25, Issue 8, August 2026.
MSC rejuvenation strategies and functional outcomes. Aging‐associated alterations in MSCs, including increased IL‐6/IL‐8 secretion, ROS accumulation, epigenetic drift, and mitochondrial dysfunction, impair stemness. Rejuvenation approaches, epigenetic modulation (VPA, AZAc, OSKM, TERT), metabolic interventions (resveratrol, calcitriol, NMD, asprosin ...
Astrid Sodomaco, Irene Bernardi, Aretha Rambaldi, Pierluigi Lombardi, Maura Rossi, Francesca Paris, Lucia Manzoli, Stefano Ratti, Francesco Alviano   +8 more
wiley   +1 more source

Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3. [PDF]

PLoS ONE, 2018
The 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) together with parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) regulates calcium (Ca2+) and phosphate (Pi) homeostasis, 1,25(OH)2D3 synthesis is mediated by hydroxylases of the cytochrome P450 ...
Larissa Kägi, Carla Bettoni, Eva M Pastor-Arroyo, Udo Schnitzbauer, Nati Hernando, Carsten A Wagner   +5 more
doaj   +1 more source

Impact of a single oral dose of 100,000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in adults with vitamin D insufficiency [PDF]

, 2017
We investigate the effect of a high dose of vitamin D3 on circulating concentrations of 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in healthy individuals with self-perceived fatigue and vitamin D insufficiency (25(OH)D3 75
Tang, Jonathan CY, Lanja Saleh, Boesch, Lukas, von Eckardstein, Arnold, Tang, Jonathan, Nowak, Albina, Joanna Gawinecka, Lukas Boesch, Gawinecka, Joanna, Arnold von Eckardstein, Albina Nowak, Jonathan Tang, William D. Fraser, Saleh, Lanja, Fraser, William D   +14 more
core   +1 more source

Vitamin D Supplementation to Prevent Post‐Thyroidectomy Hypocalcemia

Clinical Endocrinology, Volume 105, Issue 2, Page 259-266, August 2026.
ABSTRACT Objective Hypocalcemia is the most common complication following thyroidectomy. Previous studies yielded inconsistent results on whether vitamin D3 prevents postoperative hypocalcemia and were conducted in non‐European countries with different dietary habits and baseline vitamin D levels.
Jeresa I. A. Willems, Daan J. L. van Twist, Kristy M. Pickwell, Patrick L. H. van Battum, Rutgert Bianchi, Annette M. Pijnenburg, James van Bastelaar, Marco Medici, Robin P. Peeters, Roderick F.A. Tummers‐de Lind van Wijngaarden   +9 more
wiley   +1 more source

The NFkB pathway is down-regulated by 1α,25(OH)2-Vitamin D3 in endothelial cells transformed by Kaposi Sarcoma-associated herpes virus G protein coupled receptor

, 2012
We have previously demonstrated that 1α,25 dihydroxy-vitamin D3 (1α,25(OH)2D3) has antiproliferative effects on the growth of endothelial cells transformed by the viral G protein-coupled receptor associated to Kaposi sarcoma (vGPCR).
Berstuy, Annemieke, González Pardo, María Verónica, D'elía, Noelia Laura, Boland, Ricardo Leopoldo, Russo, Ana Josefa, Verónica Gonzalez-Pardo, Noelia D’Elia, Annemieke Verstuyf, Ricardo Boland, Ana Russo de Boland   +9 more
core   +1 more source

Impact of a single oral dose of 100,000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in adults with vitamin D insufficiency [PDF]

, 2021
Background: We investigate the effect of a high dose of vitamin D3 on circulating concentrations of 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in healthy individuals with self-perceived fatigue and vitamin D insufficiency [
Fraser, William D., Gawinecka, Joanna, Boesch, Lukas, Saleh, Lanja, von Eckardstein, Arnold, Tang, Jonathan, Nowak, Albina   +6 more
core  

Vitamin D receptor signaling in inflammatory senescence–associated skin aging: Mechanisms and therapeutic potentials

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Vitamin D receptor (VDR) signaling is implicated in inflammatory senescence‐associated skin aging, a growing health concern in aging populations where cellular senescence and chronic inflammation converge to create complex pathophysiological conditions.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source