Results 61 to 70 of about 62,864,054 (165)

Neuropathic Pain Comorbid Cognitive Impairment and Vitamin D: A Narrative Review From Mechanisms to Clinical Management

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Vitamin D is an essential fat‐soluble nutrient primarily obtained through cutaneous synthesis triggered by ultraviolet exposure and dietary intake. After systemic metabolism and activation, it binds to vitamin D receptors widely distributed in the central and peripheral nervous systems, exerting pleiotropic neuroprotective and regulatory biological ...
Nan Zhao, Yang Yang, Wanqiu Yu, Yuhang Zhu, Zhaoqiong Zhu   +4 more
wiley   +1 more source

Low bone mineral density due to secondary hyperparathyroidism in the GlatmTg(CAG‐A4GALT) mouse model of Fabry disease

FASEB BioAdvances, 2020
Low bone mineral density (BMD)—diagnosed as osteoporosis or osteopenia—has been reported as a new characteristic feature of Fabry disease; however, the mechanism underlying the development of low BMD is unknown.
Hiroki Maruyama, Atsumi Taguchi, Mariko Mikame, Hongmei Lu, Norihiro Tada, Muneaki Ishijima, Haruka Kaneko, Mariko Kawai, Sawako Goto, Akihiko Saito, Riuko Ohashi, Yuji Nishikawa, Satoshi Ishii   +12 more
doaj   +1 more source

24R,25-Dihydroxyvitamin D3 Promotes the Osteoblastic Differentiation of Human Mesenchymal Stem Cells

, 2014
Although 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] is considered the most biologically active vitamin D3 metabolite, the vitamin D3 prohormone, 25-hydroxyvitamin D3 [25(OH)D3], is metabolized into other forms, including 24R,25-dihydroxyvitamin D3 [24R,25 ...
Curtis, Kevin M, Roos, Bernard A, Aenlle, Kristina K, Howard, Guy A   +3 more
core   +1 more source

TA10 Titanium Alloy in HCl Solution: W‐Influenced Corrosion and Passivation Film Evolution

Rare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT This work investigated the evolution of passive films of Ti–0.3Mo–0.8Ni (TMN) in 5 mol L−1 HCl and studied the influence of W on the anti‐corrosion properties of TMN. The intermittent electrochemical impedance spectroscopy test results showed that when TMN entered 5 mol L−1 HCl solution, the stability of the passive film first became stronger ...
Chaowen Zheng, Qi Wang, Shuo Yin, Guanshi Zheng, Wei Wei, Baoxian Su, Xin Ding, Ruirun Chen   +7 more
wiley   +1 more source

Human osteoblasts exhibit sexual dimorphism in their response to estrogen on microstructured titanium surfaces

Biology of Sex Differences, 2018
Background Osseointegration is dependent on the implant surface, surrounding bone quality, and the systemic host environment, which can differ in male and female patients.
Michael B. Berger, David J. Cohen, Rene Olivares-Navarrete, Joseph K. Williams, David L. Cochran, Barbara D. Boyan, Zvi Schwartz   +6 more
doaj   +1 more source

Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial. [PDF]

, 2019
CONTEXT: Vitamin D2 and vitamin D3 have been hypothesized to exert differential effects on vitamin D metabolism. OBJECTIVE: To compare the influence of administering vitamin D2 vs vitamin D3 on metabolism of vitamin D3.
Wang, Z, Boucher, BJ, Jolliffe, DA, Hitman, GA, Forouhi, NG, Thummel, KE, Griffin, SJ, Martineau, AR   +7 more
core   +2 more sources

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

1α,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells

, 2017
Vitamin D supplementation is regarded as a novel approach to treat Alzheimer’s disease, but the underlying mechanism remains elusive. The cytokine IL-34 provides strong neuroprotective and survival signals in brain injury and neurodegeneration and could
Jialiang Zhu, Dong Zhang, Huiming Wang, Yongji Zhu, Heinrich Korner, Zhangming Chen, Yang Dong, Yujun Shen, Shengyun Fang, Xingyun Liu, Xuwen Liu, Xinhui Zhang, Yuxian Shen, Songcheng Ying, Miaomiao Li   +14 more
core   +2 more sources

The biological-activity of 23-oxa-dihydroxyvitamin-D-3, 23-oxa-24-oxo-dihydroxyvitamin-D-3, and 23-thia-dihydroxyvitamin-D-3

, 1994
Three analogs of 1α,25-(OH)2D3 with an oxygen or another heteroatom at position 23 were synthesized in search of separating the cell-differentiating from the calcemic effects of the vitamin D hormone.
Zhao, Xu-yang, Bouillon, Roger, Convents, Renilde, De Clercq, PierreWE07801000247611F3744AB8-F0ED-11E1-A9DE-61C894A0A6B4, Tan, Biauw Keng, De Clercq, Pierre, Vandewalle, Maurits, Vandewalle, Maurits8010000364336F40B448-B25E-11E6-B104-2D2FD0AF0289, Allewaert, Katrien, Marcelis, Suzanne, Zhao, Jie   +10 more
core   +1 more source

Supraphysiological 25‐Hydroxyvitamin D3 and Calcipotriol Induce Reactive Oxygen Species, Mitochondrial Dysfunction and Apoptosis in HeLa Cervical Cancer Cells

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Supraphysiological 25(OH)D3 and calcipotriol induced ROS accumulation or redox disturbance, increased mitochondrial membrane depolarization, reduced antioxidant enzyme activity, and caused apoptotic cell death in HeLa cells. ABSTRACT Cervical cancer remains a major global health challenge, necessitating continued advances in therapeutic strategies ...
Hoi Ching Cherry Chan, Sachin Bhoora, Esther Zhou, Sumari Marais, Tahir S. Pillay, Rivak Punchoo   +5 more
wiley   +1 more source