Results 51 to 60 of about 62,864,054 (165)
Vitamin D: Physiology, Pharmacology and Clinical Evidence for Supplementation—A Narrative Review
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.ABSTRACT Vitamin D is a nutrient and prohormone obtained from diet and supplements and synthesized in the skin. It is essential for calcium and phosphate homeostasis and skeletal health and influences multiple extra‐skeletal processes, yet deficiency remains common worldwide.
Jyrki K. Virtanen
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10603-10614, November 2026.ABSTRACT Aims This study aimed to perform an exploratory characterisation of metabolic phenotypes in primary care patients with type 2 diabetes mellitus (T2DM), using a predefined approach and examine their association with vitamin D status. Materials and Methods This cross‐sectional study included 178 participants randomly selected in Sergipe, Brazil.
Liliane Viana Pires +10 more
wiley +1 more source
VDR agonists down regulate PI3K/Akt/mTOR axis and trigger autophagy in Kaposi's sarcoma cells
Heliyon, 2019 The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor (KSHV/vGPCR) is a key molecule in the pathogenesis of Kaposi's sarcoma. We have previously shown that 1α,25(OH)2D3 or its less-calcemic analog TX 527 inhibits the proliferation of ...
Alejandra Suares +2 more
doaj +1 more source
Impaired bone formation in Pdia3 deficient mice. [PDF]
PLoS ONE, 2014 1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3] is crucial for normal skeletal development and bone homeostasis. Protein disulfide isomerase family A, member 3 (PDIA3) mediates 1α,25(OH)2D3 initiated-rapid membrane signaling in several cell types. To understand
Yun Wang +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Microbe-associated molecular patterns, such as lipopolysaccharide (LPS) and β-glucan (BG), are surrogates of immune challenges like bacterial and fungal infections, respectively.
Henna-Riikka Malmberg +5 more
doaj +1 more source
Tyrosine phosphorylation signalling dependent on 1α,25(OH) 2-vitamin D3 in rat intestinal cells: Effect of ageing [PDF]
, 2004 In intestinal cells, as in other target cells, 1α,25(OH) 2D3 elicits long-term and short-term responses which involve genomic and non-genomic mode of actions, respectively. There is evidence indicating that activation of tyrosine phosphorylation pathways
González Pardo, María Verónica +1 more
core +1 more source
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT Gynaecological malignancies account for over 1.4 million new diagnoses, with outcomes constrained by late‐stage presentation and chemoresistance. Dysregulated redox homeostasis is a hallmark of tumourigenesis. Tumour cells maintain elevated basal reactive oxygen species (ROS), which support proliferative signalling but may also increase ...
Hoi Ching Cherry Chan +4 more
wiley +1 more source
The impact of 1α,25(OH)2D3 on genome-wide methylation
, 2021 A dissertation submitted in fulfilment of the requirements for the degree Master of Science in Molecular and Cell Biology in the Faculty of Science, University of the Witwatersrand, 2021Vitamin D is a fat-soluble hormone attained through UV ...
Nyamupangedengu, Kudakwashe
core
Journal of Nutritional Science, 2020 Neonatal mortality rates in Indonesia are still at an alarming rate, with preterm birth as one of the causes. Nutritional deficiencies such as low level of vitamin D is suspected to be the risk factors of preterm birth but still a little knowledge about ...
Rima Irwinda, Biancha Andardi
doaj +1 more source
Antagonistic property of DLAM-2s in VDR binding and 1α,25(OH)2D3- induced HL60 cytodifferentiation.
, 2023 Antagonistic property of DLAM-2s in VDR binding and 1α,25(OH)2D3- induced HL60 cytodifferentiation.
Yoshiaki Kanemoto (17628166) +7 more
core +1 more source