Results 31 to 40 of about 62,864,054 (165)

1α,25(OH)2D3 downregulates gene expression levels of muscle ubiquitin ligases MAFbx and MuRF1 in human myotubes [PDF]

, 2015
Clinical trials involving in patients with osteoporosis have reported that activated vitamin D3 (1α,25(OH)2D3, calcitriol) can prevent falling by acting on the skeletal muscles. However, pharmacological mechanisms of 1α,25(OH)2D3 with respect to skeletal
Fukumura, Junko, Fujimoto-Ouchi, Kaori, Yasuno, Hideyuki, Kitamura, Hidemitsu, Hayakawa, Naohiko   +4 more
core   +1 more source

Differential profiles of chromatin accessibility by DLAM-2b and 1α,25(OH)₂ vitamin D₃.

, 2023
(A) Venn diagram was used to assess chromatin accessibility profiles of VDR ligand-regulated target regions measured by ATAC-Seq in HaCaT cells. 1α,25(OH)2D3 (VD) and DLAM-2b regulated target regions were selected with p-value2b for expression of the ...
Yoshiaki Kanemoto (17628166), Shigeaki Kato (294800), Rino Tsutsumi (17628172), Miho Iwaki (17628163), Tomohiro Kurokawa (15031457), Kazuo Nagasawa (1685587), Koki Nojiri (17628169), Takahiro Sawada (184183)   +7 more
core   +1 more source

Additional file 2 of Local nebulization of 1α,25(OH)2D3 attenuates LPS-induced acute lung inflammation

, 2022
Additional file 2. Representative examples of sagittal lung sections stained with Hematoxylin and Eosin in LPS-treated vitamin D sufficient and deficient mice either pretreated with 1α,25(OH)2D3 ...
Tom Tanjeko Ajime (12318574), Wim Janssens (101722), Karen Maes (443361), Didier Cataldo (231530), Carolien Mathyssen (2938746), Tobias Heigl (6636725), Annemieke Verstuyf (253988), Jeroen Vanoirbeek (143448), Bart Vanaudenaerde (187740), Jef Serré (8930834), Lieve Verlinden (2345767), Ghislaine Gayan-Ramirez (12188750)   +11 more
core   +1 more source

1α,25(OH)2-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: its synthesis, biological activity and crystal structure with its receptor.

PLoS ONE, 2011
BackgroundThe 1α,25-dihydroxy-3-epi-vitamin-D3 (1α,25(OH)2-3-epi-D3), a natural metabolite of the seco-steroid vitamin D3, exerts its biological activity through binding to its cognate vitamin D nuclear receptor (VDR), a ligand dependent transcription ...
Ferdinand Molnár, Rita Sigüeiro, Yoshiteru Sato, Clarisse Araujo, Inge Schuster, Pierre Antony, Jean Peluso, Christian Muller, Antonio Mouriño, Dino Moras, Natacha Rochel   +10 more
doaj   +1 more source

Macrophages Control the Bioavailability of Vitamin D and Vitamin D-Regulated T Cell Responses

Frontiers in Immunology, 2021
The active form of vitamin D3 (1,25(OH)2D3) has a great impact on T cell effector function. Thus, 1,25(OH)2D3 promotes T helper 2 (Th2) and regulatory T (Treg) cell function and concomitantly inhibits Th1 and Th17 cell function. Thus, it is believed that
Daniel Villalba Lopez, Fatima A. H. Al-Jaberi, Anders Woetmann, Niels Ødum, Charlotte Menné Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler   +6 more
doaj   +1 more source

Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy

Stem Cell Research & Therapy, 2021
Background Vitamin D is important for the mineralization of bones by stimulating osteoblast differentiation of bone marrow mesenchymal stem cells (BMMSCs).
Qiting He, Ruixi Qin, Julie Glowacki, Shuanhu Zhou, Jie Shi, Shaoyi Wang, Yuan Gao, Lei Cheng   +7 more
doaj   +1 more source

25(OH)D Is Effective to Repress Human Cholangiocarcinoma Cell Growth through the Conversion of 25(OH)D to 1α,25(OH)2D3

, 2016
Cholangiocarcinoma (CCA) is a devastating disease without effective treatments. 1α,25(OH)2D3, the active form of Vitamin D, has emerged as a new anti-cancer regimen. However, the side effect of hypercalcemia impedes its systemic administration.
Cheng-Cheng Huang, Ta-Sen Yeh, Sheng-Fong Kuo, Kun-Chun Chiang, Jun-Te Hsu, Li-Wei Chen, Chun-Nan Yeh, Horng-Heng Juang, Jong-Hwei S. Pang, Atsushi Kittaka, Tai Chen   +10 more
core   +1 more source

Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system

ALTEX: Alternatives to Animal Experimentation, 2018
The role of megalin in the regulation of renal vitamin D homeostasis has previously been evaluated in megalin-knockout mice and rat proximal tubule epithelial cells. We revisited these hypotheses that were previously tested solely in rodent models, this
Brian D. Chapron, Alenka Chapron, Brian Phillips, Miracle C. Okoli, Danny D. Shen, Edward J. Kelly, Jonathan Himmelfarb, Kenneth E. Thummel   +7 more
doaj   +1 more source

Differential expression profiles of the genes regulated by DLAM-2b and 1α,25(OH)₂ vitamin D₃.

, 2023
(A, B) Venn diagram was used to identify VDR target genes regulated by DLAM-2b and 1α,25(OH)2D3 (VD) in wild-type and VDR KO HCT116. The numbers of the VDR target genes regulated by the two VDR ligands are depicted. (C, D) Venn diagram shows differential
Yoshiaki Kanemoto (17628166), Shigeaki Kato (294800), Rino Tsutsumi (17628172), Miho Iwaki (17628163), Tomohiro Kurokawa (15031457), Kazuo Nagasawa (1685587), Koki Nojiri (17628169), Takahiro Sawada (184183)   +7 more
core   +1 more source

1α,25(OH)2D3-dependent modulation of Akt in proliferating and differentiating C2C12 skeletal muscle cells

, 2012
We previously reported that 1α,25‐dihydroxy‐vitamin D3 [1α,25(OH)2D3] induces non‐transcriptional rapid responses through activation of Src and MAPKs in the skeletal muscle cell line C2C12.
Arango, Nadia Soledad, Nadia S. Arango, Claudia G. Buitrago, Boland, Ricardo Leopoldo, Ricardo L. Boland, Buitrago, Claudia Graciela   +5 more
core   +1 more source