Results 21 to 30 of about 62,864,054 (165)

Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cells.

PLoS ONE, 2023
Vitamin D (VD) exerts a wide variety of biological functions including calcemic activity. VD nutritional status is closely associated with the onset and development of chronic diseases.
Miho Iwaki, Yoshiaki Kanemoto, Takahiro Sawada, Koki Nojiri, Tomohiro Kurokawa, Rino Tsutsumi, Kazuo Nagasawa, Shigeaki Kato   +7 more
doaj   +1 more source

In vitro effects of 1α,25(OH)2D3-glycosides from Solbone A (Solanum glaucophyllum leaves extract; Herbonis AG) compared to synthetic 1α,25(OH)2D3 on myogenesis [PDF]

, 2016
The presence of glycoside derivatives of 1α,25(OH)2D3 endows plants to gradual release of the free bioactive form of 1α,25(OH)2D3 from its glycoconjugates by endogenous animal tissue glycosidases.
González Pardo, María Verónica, Gili, Valeria, de Genaro, Pablo Adrian, Boland, Ricardo Leopoldo, Ronda, Ana Carolina, Bachman, Heini, Russo, Ana Josefa   +6 more
core   +1 more source

The 1α,25(OH)₂D₃ Analogs ZK159222 and ZK191784 Show Anti-Inflammatory Properties in Macrophage-Induced Preadipocytes via Modulating the NF-κB and MAPK Signaling. [PDF]

Diabetes Metab Syndr Obes, 2020
Purpose:Key research findings suggest that attenuating metaflammation in adipose tissue might be a strategic step to prevent the metabolic syndrome and its associated disease outcomes.
Zhu J, Wilding JPH.
europepmc   +2 more sources

Vitamin D regulates ion regulation by affecting the ionocyte differentiation in zebrafish (Danio rerio) larvae

Frontiers in Marine Science, 2023
Freshwater teleosts frequently face the stress of varied ion and pH levels; therefore, they have developed related defense mechanisms to maintain the homeostasis of body-fluid ion and acid-base balance.
Chia-Hao Lin, Chia-Hao Lin, Hung-Chi Chang, Sian-Tai Liu, Sian-Tai Liu, Huei-Jyun Hu   +5 more
doaj   +1 more source

Differential enrichment of transcription factor-binding sequences induced by DLAM-2b and 1α,25(OH)₂ vitamin D₃.

, 2023
(A, B) The transcription factor-binding sequences in ATAC-seq peaks based on HOMER (http://homer.ucsd.edu/homer/) analysis in HaCaT cells treated with 1α,25(OH)2D3(VD) or DLAM-2b for 8 hours were searched and calculated. The top 10 motifs regulated by 1α,
Yoshiaki Kanemoto (17628166), Shigeaki Kato (294800), Rino Tsutsumi (17628172), Miho Iwaki (17628163), Tomohiro Kurokawa (15031457), Kazuo Nagasawa (1685587), Koki Nojiri (17628169), Takahiro Sawada (184183)   +7 more
core   +1 more source

1α, 25-dihydroxyvitamin D3 inhibits transforming growth factor β1-induced epithelial-mesenchymal transition via β-catenin pathway

Chinese Medical Journal, 2020
. Background:. The transforming growth factor β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) has been proven associated with the pathogenesis of asthmatic airway remodeling, in which the Wnt/β-catenin pathway plays an important role, notably
Xin-Rong Xiong, Xin-Li Tian, Ru-Jie Huo, Yan-Ting Dong, Dai Liu, Jing-Cui Bai, Yun-Feng Qi, Xin-Rui Tian, Xiu-Yuan Hao   +8 more
doaj   +1 more source

Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats

Scientific Reports, 2022
Active vitamin D form 1α,25-dihydroxtvitamin D3 (1,25(OH)2D3) plays pivotal roles in calcium homeostasis and osteogenesis via its transcription regulation effect via binding to vitamin D receptor (VDR).
Miyu Nishikawa, Naruhiro Murose, Hiroki Mano, Kaori Yasuda, Yasuhiro Isogai, Atsushi Kittaka, Masashi Takano, Shinichi Ikushiro, Toshiyuki Sakaki   +8 more
doaj   +1 more source

Gene-Regulatory Potential of 25-Hydroxyvitamin D3 and D2

Frontiers in Nutrition, 2022
Human peripheral blood mononuclear cells (PBMCs) represent a highly responsive primary tissue that is composed of innate and adaptive immune cells.
Andrea Hanel, Cor Veldhuizen, Carsten Carlberg, Carsten Carlberg   +3 more
doaj   +1 more source

TAp63γ and ΔNp63β promote osteoblastic differentiation of human mesenchymal stem cells: regulation by vitamin D3 Metabolites. [PDF]

PLoS ONE, 2015
The transcription factor p63 is required for skeletal formation, and is important for the regulation of 1α,25(OH)2D3 receptor (VDR) in human mesenchymal stem cells (hMSC).
Kevin M Curtis, Kristina K Aenlle, Rachel N Frisch, Guy A Howard   +3 more
doaj   +1 more source

Cadmium Toxicity on Chondrocytes and the Palliative Effects of 1α, 25-Dihydroxy Vitamin D3 in White Leghorns Chicken's Embryo

Frontiers in Veterinary Science, 2021
Cadmium (Cd) can causes osteoporosis and joint swelling. However, the mechanism of Cd toxicity in chondrocytes and how to alleviate Cd poisoning to chondrocytes are still unclear.
Jianhong Gu, Jianhong Gu, Jianhong Gu, Saihui Li, Saihui Li, Guoshuai Wang, Guoshuai Wang, Xueqing Zhang, Xueqing Zhang, Yan Yuan, Yan Yuan, Xuezhong Liu, Xuezhong Liu, Xuezhong Liu, Jianchun Bian, Jianchun Bian, Jianchun Bian, Xishuai Tong, Xishuai Tong, Xishuai Tong, Xishuai Tong, Zongping Liu, Zongping Liu, Zongping Liu, Zongping Liu   +24 more
doaj   +1 more source