1α,25(OH)2D3 Radiosensitizes Cancer Cells by Activating the NADPH/ROS Pathway [PDF]
Frontiers in Pharmacology, 2020 The radioresistance of tumors affect the outcome of radiotherapy. Accumulating data suggest that 1α,25(OH)2D3 is a potential anti-oncogenic molecule in various cancers.
Guang-Ming Zhou, Zeng-Li Zhang
exaly +4 more sources
Vitamin D (1α,25(OH)2D3) supplementation minimized multinucleated giant cells formation and inflammatory response during Burkholderia pseudomallei infection in human lung epithelial cells [PDF]
PLoS ONE, 2023 Melioidosis is an infectious disease with high mortality rates in human, caused by the bacterium Burkholderia pseudomallei. As an intracellular pathogen, B.
Pohnratchada Mattrasongkram +6 more
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Simultaneous determination of vitamin D metabolites 25(OH)D3 and 1α,25(OH)2D3 in human plasma using liquid chromatography tandem mass spectrometry [PDF]
Journal of Mass Spectrometry and Advances in the Clinical Lab, 2022 Background: Although measurement of 25(OH)D3 is a routine analytical method to determine plasma vitamin D status, 1α,25(OH)2D3 is the biologically active form. Hence, simultaneous measurement of 25(OH)D3 and 1α,25(OH)2D3 could provide better insight into
Shan Xu +6 more
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Local nebulization of 1α,25(OH)2D3 attenuates LPS-induced acute lung inflammation [PDF]
Respiratory Research, 2022 Background Evidence supports a critical role of vitamin D status on exacerbation in chronic obstructive pulmonary disease, indicating the need to avoid vitamin D deficiency in these patients.
Jef Serré +11 more
doaj +2 more sources
Knockdown of CYP24A1 Aggravates 1α,25(OH)2D3-Inhibited Migration and Invasion of Mouse Ovarian Epithelial Cells by Suppressing EMT [PDF]
Frontiers in Oncology, 2020 Epithelial-mesenchymal transition (EMT) bestows cancer cells with motile and invasive properties. But for ovarian tissues, EMT plays a physiological role in the postovulatory repair of ovary surface epithelial (OSE) cells.
Ping Wang +11 more
doaj +2 more sources
1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells [PDF]
Journal for ImmunoTherapy of Cancer, 2022 Background Epidemiological surveys have revealed that low serum vitamin D level was correlated with increased risk of tumors. Dysfunctional T cells in patients with tumor are characterized as exhausted with high levels of immune checkpoint receptors ...
Peng Li +13 more
doaj +2 more sources
Down-regulation of COX-2 activity by 1α,25(OH)2D3 is VDR dependent in endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor [PDF]
Heliyon, 2020 Our previous reports showed that 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) has antiproliferative actions in endothelial cells stably expressing viral G protein-coupled receptor (vGPCR) associated with the pathogenesis of Kaposi's sarcoma.
Cinthya Tapia +7 more
doaj +2 more sources
Gene expression profiles in human and mouse primary cells provide new insights into the differential actions of vitamin D3 metabolites. [PDF]
PLoS ONE, 2013 1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) had earlier been regarded as the only active hormone. The newly identified actions of 25-hydroxyvitamin D3 (25(OH)D3) and 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3) broadened the vitamin D3 endocrine system ...
Pentti Tuohimaa +8 more
doaj +1 more source
A Newly Identified lncBCAS1-4_1 Associated With Vitamin D Signaling and EMT in Ovarian Cancer Cells
Frontiers in Oncology, 2021 Long noncoding RNAs (lncRNAs) were identified rapidly due to their important role in many biological processes and human diseases including cancer.
Yaqi Xue +8 more
doaj +1 more source
24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats. [PDF]
PLoS ONE, 2016 Osteoarthritis (OA) in humans is associated with low circulating 25-hydroxyvitamin D3 [25(OH)D3]. In vitamin D replete rats, radiolabeled 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] accumulates in articular cartilage following injection of [3H]-25(OH)D3 ...
Barbara D Boyan +6 more
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