Cellular Physiology and Biochemistry, 2016 Background: Cell proliferation and motility require actin reorganization, which is under control of various signalling pathways including ras-related C3 botulinum toxin substrate 1 (RAC1), p21 protein-activated kinase 1 (PAK1) and actin related protein 2
Ni Zeng +6 more
doaj +2 more sources
Low serum 1,25(OH)2D3 in end-stage renal disease: is reduced 1α-hydroxylase the only problem?
Endocrine Connections, 2021 Low serum 1,25-dihydroxyvitamin D (1,25(OH)2D) in end-stage renal disease (ESRD) is considered a consequence of elevated fibroblast growth factor 23 (FGF23) and concomitant reduced activity of renal 1α-hydroxylase (CYP27B1).
Sharon A Huish +5 more
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1α,25(OH)2D3-glycosides from Solanum glaucophyllum leaves extract induce myoblasts differentiation through p38 MAPK and AKT activation [PDF]
Biology Open, 2018 We have previously shown that Solanum glaucophyllum leaf extract (SGE) increases VDR protein levels and promotes myoblast differentiation. Here, we investigated whether p38 MAPK and AKT are involved in SGE actions.
Ana Paula Irazoqui +5 more
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Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)2D3
Cell Reports, 2017 1α,25(OH)2D3 (vitamin D3) is crucial for mineral homeostasis in mammals, but the precise effects of 1α,25(OH)2D3 in adipose tissue remain to be clarified in vivo. The initial 25-hydroxylation is catalyzed by liver microsomal cytochrome P450 2R1 (CYP2R1),
Xuyan Peng +12 more
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Co-expression of 1α-hydroxylase and vitamin D receptor in human articular chondrocytes [PDF]
BMC Musculoskeletal Disorders, 2017 Background The aim was to investigate whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active hormone 1α,25(OH)2D3, namely 1α ...
Ann Kristin Hansen +2 more
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CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes. [PDF]
PLoS ONE, 2013 CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced ...
Thea K Wöbke +3 more
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H3K4me3 Is a Potential Mediator for Antiproliferative Effects of Calcitriol (1α,25(OH)2D3) in Ovarian Cancer Biology. [PDF]
Int J Mol Sci, 2020 Posttranslational histone modification plays an important role in tumorigenesis. Histone modification is a dynamic response of chromatin to various signals, such as the exposure to calcitriol (1α,25(OH)2D3).
Han N +9 more
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PLoS ONE, 2015 Transforming growth factor-beta3 (TGF-β3) and 1α,25-dihydroxyvitamin D3 (1α,25 (OH) 2D3) are essential factors in chondrogenesis and osteogenesis respectively.
Emma L Smith +4 more
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Systematic Optimization of an SLE-DAPTAD LC-MS/MS Workflow for Simultaneous Quantification of Low-Abundance Vitamin D<sub>3</sub> Metabolites in Plasma. [PDF]
Rapid Commun Mass SpectromABSTRACT Rationale Liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis of vitamin D3 metabolites is analytically challenging because these compounds are structurally similar, strongly matrix‐associated, and have poor ionization efficiency.
Amirmostofian M +3 more
europepmc +2 more sources
Utilizing cooled liquid chromatography and chemical derivatization to separate and quantify C3-epimers of 25-hydroxy vitamin D and low abundant 1α,25(OH)2D3: Application in a pediatric population. [PDF]
J Steroid Biochem Mol Biol, 2020 There is need for a single assay able to quantify the most biologically active metabolite, 1α,25-dihydroxy-vitamin-D3, and the recently discovered biologically distinct C3-epimers of 25OHD, in addition to traditional vitamin D metabolites. We developed a
DeFelice BC +6 more
europepmc +2 more sources