Results 181 to 190 of about 659,249 (217)

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1‐Dependent Suppression of ROMK

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Wakako Kawarazaki, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Takeshi Marumo, Toshiro Fujita   +6 more
wiley   +1 more source

A new metabolic path in type 3 rickets. [PDF]

FEBS J
Senda T, Hirota Y.
europepmc   +1 more source

Vitamin D Signaling in Neurodegenerative Disorders: Mechanisms, Therapeutic Potential, and Clinical Implications. [PDF]

Nutrients
Soni N, Debnath N, Rekapally E, Jabbar A, Tyagi SC, Bissa B, Tyagi N.   +6 more
europepmc   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, Volume 293, Issue 21, Page 6444-6466, November 2026.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Serum sLOX-1 and 25-Hydroxyvitamin D₃ Across the Glycemic Spectrum: Associations with Metabolic and Microvascular Parameters in Prediabetes and Type 2 Diabetes. [PDF]

J Clin Med
Alagoz MH, Adas M, Gokden Y, Guntas G.
europepmc   +1 more source

Co-occurrence of pathogenic <i>CYP24A1</i> gene variants and primary hyperparathyroidism: a diagnostic challenge. [PDF]

JBMR Plus
Della Valentina S, Pierotti L, Sardella C, Dal Lago A, Caligo MA, Giamborino A, Cetani F.   +6 more
europepmc   +1 more source

Through the Cracks: Sea Ice Regions as a Source of Volatile Marine Sulfur in the Springtime Arctic

Journal of Geophysical Research: Atmospheres, Volume 131, Issue 20, 28 October 2026.
Abstract Marine volatile methylated sulfur compounds (VMS) including dimethyl sulfide (DMS) and methanethiol (MeSH), are important natural sources of sulfur to the atmosphere and precursors to aerosols and cloud condensation nuclei. However, observations of DMS and MeSH in regions with sea ice remain limited.
Nicole A. June, Cort L. Zang, Samuel E. O’Donnell, Ben G. Kopec, Anderson Da Silva, Betty Croft, Rachel Y.‐W. Chang, Linia Tashmim, Antoine Haddon, Shengqian Zhou, William C. Porter, Jeffrey M. Welker, Shantanu H. Jathar, Nadja Steiner, Michael Tjernström, Paul Zieger, Megan D. Willis, Jeffrey R. Pierce   +17 more
wiley   +1 more source

Vitamin D Receptor-Macrophage-IL-23 Axis in Inflammatory Bowel Disease: Pathogenic Mechanisms and Therapeutic Hope. [PDF]

J Clin Med
Grigoraș A, Ghemiș L, Goriuc A, Murariu A, Fiterman N, Jdid N, Blaga T, Foia GL.   +7 more
europepmc   +1 more source

Carba‐closo‐dodecaborates as Superchaotropic Anions

Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.
The singly charged boron cluster anion CB11H12– forms strong inclusion complexes with cyclodextrins, interacts strongly with nonionic polymers, and serves as an effective transmembrane carrier, positioning itself as the smallest superchaotropic anion known to date. .
Andrea Barba‐Bon, Guillermo E. Quintero, Maryam Ashjari, Ivana Nikšić‐Franjić, Kai‐Jen Tsung, Xiaojuan Wang, Margarita E. Aliaga, Bohumir Grüner, Werner M. Nau   +8 more
wiley   +1 more source

Directional Second Sphere Effect on CO2 Activation and Reduction by Iron Porphyrin in Aprotic and Protic Media

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Directional control within the secondary coordination sphere redefines CO2 reduction by iron porphyrins. Simply rearranging identical urea hydrogen‐bond donors modulates reactivity, revealing that optimal catalysis does not only arise from maximal intermediate stabilization, but also from directional, adaptive non‐covalent interactions that balance ...
Ashutosh Vishwakarma, Sami Essid, Sarah Bouery, Régis Guillot, Bernard Boitrel, Philipp Gotico, Marie Sircoglou, Zakaria Halime   +7 more
wiley   +2 more sources