1-Deoxynojirimycin from mulberry leaves changes gut digestion and microbiota composition in geese [PDF]
Poultry Science, 2020 This study was aimed to investigate whether 1-deoxynojirimycin (DNJ) affects the digestion system of young geese and assess whether mulberry leaf, which contains this substance, has disadvantages that compromise its value as poultry feed. One hundred and
Qirui Hou +5 more
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Effect of Mulberry Leaf and Its Active Component, 1-Deoxynojirimycin, on Palmitic Acid-Induced Lipid Accumulation in HepG2 Cells [PDF]
BiomedicinesObjectives: Aqueous mulberry leaf extract (MLE) contains 1-deoxynojirimycin (DNJ) and L-leucine (LL). This study investigated the effects of MLE, DNJ, and LL on lipid accumulation caused by palmitic acid (PA) in human hepatoma HepG2 cells, pro ...
Dahae Lee +9 more
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1-Deoxynojirimycin: Sources, Extraction, Analysis and Biological Functions [PDF]
Natural Product Communications, 2017 1-Deoxynojirimycin (DNJ), a natural polyhydroxylated piperidine alkaloid, is attracting growing attention due to its important biological functions. This paper introduces the discovery and origins of DNJ, its extraction, purification, and physiological ...
Niannian Wang, Feifei Zhu, Keping Chen
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Effects of 1-Deoxynojirimycin Extracts of Mulberry Leaves on Oxidative Stress and the Function of the Intestinal Tract in Broilers Induced by H2O2 [PDF]
AnimalsThe poultry industry struggles with oxidative stress affecting gut health and productivity. This study examined using 1-Deoxynojirimycin (DNJ) extracts from mulberry leaves as an antioxidant in broilers feed to combat this issue. We divided 240 broilers,
Chengfeng Zhao +10 more
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The Gut Microbiota-Produced Indole-3-Propionic Acid Confers the Antihyperlipidemic Effect of Mulberry-Derived 1-Deoxynojirimycin [PDF]
mSystems, 2020 Hyperlipidemia is a worldwide epidemic with an obvious gender disparity in incidence. Modulations on gut microbiota by traditional Chinese medicines (TCM) are emerging as a potential rationale governing the profitable effects of drugs on hyperlipidemia ...
Yougui Li +7 more
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Transcriptome analysis and identification of key genes involved in 1-deoxynojirimycin biosynthesis of mulberry (Morus alba L.) [PDF]
PeerJ, 2018 Mulberry (Morus alba L.) represents one of the most commonly utilized plants in traditional medicine and as a nutritional plant used worldwide. The polyhydroxylated alkaloid 1-deoxynojirimycin (DNJ) is the major bioactive compounds of mulberry in ...
Dujun Wang +6 more
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Asymmetric total synthesis of L-allo-1-deoxynojirimycin [PDF]
ARKIVOC, 2015 Asymmetric total synthesis of L-allo -1-deoxynojirimycin (L-allo -DNJ) was achieved from cis - butene-1,4-diol by employing Sharpless asymmetric dihydroxylation, stereoselective flash dihydroxylation and ring enlargement reactions as k ey steps.
Subhash P. Chavan +4 more
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1-Deoxynojirimycin with theaflavins ameliorates high-fat diet-induced insulin resistance in mice by modulating the gut microbiota [PDF]
Frontiers in NutritionBackgroundThis study investigated the ameliorative effects of combined 1-DNJ and TFs on IR in mice through gut microbiota modulation.MethodsAn HFD-induced IR model was established in male mice, which were subsequently divided into Control, Model, 1-DNJ ...
Qiannan Di +9 more
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1-Deoxynojirimycin in Mulberry (Morus indica L.) Leaves Ameliorates Stable Angina Pectoris in Patients With Coronary Heart Disease by Improving Antioxidant and Anti-inflammatory Capacities [PDF]
Frontiers in Pharmacology, 2019 Objective: Stable angina pectoris (SAP) in patients with coronary heart disease (CHD) and blood stasis syndrome (BSS) is a potentially serious threat to public health. NF-κB signaling is associated with angina pectoris. 1-Deoxynojirimycin (DNJ), which is
Yan Ma, Wei Lv, Yan Gu, Shui Yu
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N-Alkyl Derivatives of Deoxynojirimycin (DNJ) as Antiviral Agents: Overview and Update [PDF]
MoleculesN-Alkyl deoxynojirimycin-derived drugs, belonging to the class of iminosugars, are well-known for their α-glucosidase inhibitory activity. N-Butyl-deoxynojirimycin (N-butyl-DNJ; NB-DNJ; also known as miglustat or UV-1) has been developed for the ...
Paola Checconi +10 more
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