Food and Nutrition Sciences, 2011 Silkworm powder containing 1-deoxynojirimycin (DNJ) has α-glucosidase inhibitory activity and is promising as a complementary and alternative medicine (CAM) agent in Japan. Silkworm powder produced in Korea was extracted with 75% ethanol. The extract was derivatized with 9-fluorenylmethyl chloroformate (FMOC-Cl), and DNJ-FMOC content was measured by ...
Kazuhisa Yatsunami +2 more
openaire +2 more sources
Glycoform Modification of Secreted Recombinant Glycoproteins through Kifunensine Addition during Transient Vacuum Agroinfiltration. [PDF]
, 2018 Kifunensine, a potent and selective inhibitor of class I α-mannosidases, prevents α-mannosidases I from trimming mannose residues on glycoproteins, thus resulting in oligomannose-type glycans.
Kailemia, Muchena J +5 more
core +3 more sources
Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry [PDF]
, 2018 The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out.
Carmona Asenjo, Ana Teresa +8 more
core +1 more source
Synthesis of 1-deoxynojirimycin and 1-deoxymannojirimycin.
Chemical and Pharmaceutical Bulletin, 1986 Here the synthesis of 1-deoxynojirimycin(1___-) and 1-deoxymannojirimycin (2___-) from D-mannose is reported and their immunostimulating activity is evaluated.
H, Setoi, H, Takeno, M, Hashimoto
openaire +3 more sources
Molecules1-deoxynojirimycin (DNJ) is a well-known α-glucosidase inhibitor. A series of phenyltriazole-deoxynojirimycin hybrids containing C4 and C6 (4 and 6 methylenes, respectively) linkers were synthesized.
Lin Wang +6 more
doaj +1 more source
A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases [PDF]
, 2007 The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described.
Adrian Scaffidi +49 more
core +1 more source
Research Progress of α-Glucosidase Inhibitors Produced by Microorganisms and Their Applications
Foods, 2023 Based on the easy cultivation of microorganisms and their short cycle time, research on α-glucosidase inhibitors (α-GIs) of microbial origin is receiving extensive attention. Raw materials used in food production, such as cereals, dairy products, fruits,
Fei Ren, Nairu Ji, Yunping Zhu
doaj +1 more source
Potency of 1 - Deoxynojirimycin Compounds for Slowed Hydrolysis of Various Carbohydrates by Raw Enzymes of the Rumen Liquid [PDF]
, 2011 Compound of 1- deoxynojirimycin (DNJ) in the mulberry leave extract (MLE) potentially hamper the hydrolysis process of various carbohydrates. This experiment aimed to study dynamic concentration of reductive sugar resulted from the hydrolysis of various ...
Parakkasi, A. (A) +4 more
core
Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review
Food Frontiers, Volume 7, Issue 2, March 2026.Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv +5 more
wiley +1 more source
Direct synthesis of anomeric tetrazolyl iminosugars from sugar-derived lactams
Beilstein Journal of Organic Chemistry, 2021 Herein we present the direct asymmetric synthesis of tetrazole-functionalized 1-deoxynojirimycin derivatives from simple sugars via a Schwartz’s reagent-mediated reductive amide functionalization followed by a variant of the Ugi–azide multicomponent ...
Michał M. Więcław, Bartłomiej Furman
doaj +1 more source