1-Deoxynojirimycin promotes cardiac function and rescues mitochondrial cristae in mitochondrial hypertrophic cardiomyopathy [PDF]
The Journal of Clinical Investigation, 2023 Hypertrophic cardiomyopathy (HCM) is the most prominent cause of sudden cardiac death in young people. Due to heterogeneity in clinical manifestations, conventional HCM drugs have limitations for mitochondrial hypertrophic cardiomyopathy.
Qianqian Zhuang +24 more
doaj +2 more sources
A Novel Strategy to Regulate 1-Deoxynojirimycin Production Based on Its Biosynthetic Pathway in Streptomyces lavendulae [PDF]
Frontiers in Microbiology, 2019 This study characterized the biosynthetic pathway of the secondary metabolite 1-deoxynojirimycin (DNJ) from Streptomyces lavendulae. The results revealed that glucose was a preferable precursor for DNJ synthesis, and its carbon skeleton underwent a C2-N ...
Hao Wu +4 more
doaj +2 more sources
Iminosugar 1-Deoxynojirimycin (DNJ) sebagai Antiviral Infeksi Virus Dengue [PDF]
Keluwih, 2020 — Dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) caused by the DENV virus are among the global problems regarding mosquito-borne viral infections.
Muhammad Luthfi Adnan
doaj +4 more sources
Evaluation of the anti-hyperglycemic effect and safety of microorganism 1-deoxynojirimycin. [PDF]
PLoS ONE, 2018 1-Deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor and thus beneficial for prevention of diabetes. While we have succeeded in obtaining the culture supernatant extract (CSE) rich in DNJ from microorganism source, information regarding its anti ...
Soo Takasu +10 more
doaj +2 more sources
Exploring the impact of 1-deoxynojirimycin on alpha-galactosidase activity and chickpea seed germination through in vitro experiments and molecular docking analysis [PDF]
Journal of Seed Science, 2023 : Seed germination is a tightly regulated physiological process. Hydrolytic enzymes provide energy that brings physiological, biochemical, and physical changes to the seed during germination.
Krishnamoorthy Vengatesh Prasanna +3 more
doaj +1 more source
New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells [PDF]
, 2013 sp2-Iminosugar-type castanospermine analogues have been shown to exhibit anti-tumor activity. However, their effects on cell proliferation and apoptosis and the molecular mechanism at play are not fully understood. Here, we investigated the effect of two
Ahidouch, Ahmed +6 more
core +11 more sources
Comparative genomic analysis of azasugar biosynthesis
AMB Express, 2021 Azasugars are monosaccharide analogs in which the ring oxygen is replaced with a nitrogen atom. These well-known glycosidase inhibitors are of interest as therapeutics, yet several aspects of azasugars remain unknown including their distribution ...
Hailey E. Beal, Nicole A. Horenstein
doaj +1 more source
Comparison between 1-deoxynojirimycin and N-methyl-1-deoxynojirimycin as inhibitors of oligosaccharide processing in intestinal epithelial cells [PDF]
Biochemical Journal, 1985 The alpha-glucosidase inhibitor N-methyl-1-deoxynojirimycin (MDJN) inhibits the synthesis of N-linked complex oligosaccharides in rat intestinal epithelial cells to the same extent as reported previously for 1-deoxynojirimycin (DJN) [Saunier, Kilker, Tkacz, Quaroni & Herscovics (1982) J. Biol. Chem. 257, 14155-14161].
P A, Romero, B, Saunier, A, Herscovics
openaire +2 more sources
Flavonoids with α-glucosidase inhibitory activities and their contents in the leaves of Morus atropurpurea [PDF]
, 2013 BACKGROUND: This study aims to isolate the α-glucosidase inhibitory compounds from mulberry leaves (Morus atropurpurea Roxb., Moraceae) and to develop an analytical method for quantification of the compounds.
Hin-Chu Hong +4 more
core +1 more source
Process optimization of supercritical carbon dioxide (SC-CO2) extraction parameters for extraction of deoxynojirimycin (1-DNJ) from mulberry (Morus alba L.) leaves [PDF]
, 2016 In the present study, supercritical fluid extraction (SFE) technology was applied to extract deoxynojirimycin (1-DNJ) from mulberry leaf powder using carbon dioxide (CO2) as major extraction solvent with ethanol as cosolvent, and extraction parameters ...
Ashoka, J. +5 more
core +2 more sources