Results 51 to 60 of about 3,850 (205)

Quantitative Analysis of 1-deoxynojirimycin in Mulberry Leaves [PDF]

Korean Journal of Sericultural Science, 2013
Countries of the world are competing for the collection and utilization of genetic resources, which is a resource of valueadded industrialization. We are building database of silkworm and mulberry resources with morphological, genetic characteristics data etc. Moreover, recent bioactive compound has been receiving increasing attention.
Hyun-Bok Kim, Sang-Deok Seo, Hui-Yeon Koo, Young-Seek Seok, Sun-Lim Kim, Gyoo-Byung Sung   +5 more
openaire   +1 more source

Energy Sufficiency of Feed Containing Fermented Mulberry Leaves (Morus alba) Determined by measurement of Glucose, Abdominal Fat and Feed Intake [PDF]

, 2013
This study was conducted to determine the effect of using rumen liquid fermented mulberry leaves in boiler???s diet on feed consumption, blood glucose, and abdominal fat.
Has, Hamdan, Sukamto, B., Yunianto, V.D.
core   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, Volume 41, Issue 3, Page 596-602, March 2026.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar [PDF]

, 2015
The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported herein. Tetrava- lent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide ...
Cardona, Francesca, Goti, Andrea, Matassini, Camilla, Mirabella, Stefania, Moreno Vargas, Antonio José, Robina Ramírez, Inmaculada   +5 more
core   +3 more sources

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

Kajian Pertumbuhan Dan Produksi Kambing Peranakan Ettawa Jantan Yang Diberi Pakan Berbeda [PDF]

, 2016
This study aimed to analyze the growth and productivity of male bred Ettawa goats that are fed with different animal feeds. The study was conducted for 4 months, from January to April 2016, at the village of Ranomentaa in the sub district of Toari ...
Baa, L. O. (La), Hafid, H. (Harapin), Suparman, S. (Suparman)   +2 more
core  

From Molecule to Meaning: Neuronopathic Biomarkers and Clinical Relevance in GM1

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT GM1 gangliosidosis is a rare, progressively neurodegenerative lysosomal storage disorder characterized by profound central nervous system involvement and substantial clinical heterogeneity. The development of reliable biomarkers is essential for tracking disease progression, stratifying patients, and advancing clinical trial readiness. Primary
Krista Casazza, Roberto Giugliani, Debra S. Regier, Jeanine Jarnes   +3 more
wiley   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Precision Activity‐Based α‐Amylase Probes for Dissection and Annotation of Linear and Branched‐Chain Starch‐Degrading Enzymes

Angewandte Chemie, Volume 137, Issue 5, January 27, 2025.
Activity‐based probes were designed as a method to annotate substrate specificity of retaining α‐amylases. Fluorescent probes were used in activity‐based protein profiling experiments with pure protein, a prominent gut microbe and in a species‐rich composter sample.
Isabelle B. Pickles, Yurong Chen, Olga Moroz, Haley A. Brown, Casper de Boer, Zachary Armstrong, Nicholas G. S. McGregor, Marta Artola, Jeroen D. C. Codée, Nicole M. Koropatkin, Herman S. Overkleeft, Gideon J. Davies   +11 more
wiley   +2 more sources

1-Deoxynojirimycin Attenuates High-Glucose-Induced Oxidative DNA Damage via Activating NRF2/OGG1 Signaling

Applied Sciences
1-Deoxynojirimycin (DNJ) is a type of alkaloid that mainly exists in mulberry fruit and leaves. DNJ inhibits α-glucosidase, reduces the absorption of sugar, and suppresses after-meal hyperglycemia.
Yuwei Chen, Jun Wang
doaj   +1 more source