Results 101 to 110 of about 21,476,808 (310)

Naphthyridine‐Based Donor–Acceptor Boron Difluoride Complexes Targeting Red Emission in Organic Light‐Emitting Diodes

Advanced Optical Materials, EarlyView.
Four donor–acceptor boron difluoride complexes based on triphenylamine donor and a naphthyridine acceptor units were synthesized, studied, and applied as OLED emitters. They exhibit pronounced intramolecular charge transfer character, balanced charge transport properties, and tunable emission. Near‐unity PLQYs are achieved for selected compounds, while
Omar Lahna, Stepan Kutsiy, Dmytro Volyniuk, Roman Luboradzki, Elina Andresen, Ute Resch‐Genger, Juozas V. Grazulevicius, Pavlo Stakhira, Mykhaylo A. Potopnyk   +8 more
wiley   +1 more source

3D Printing of Soft Robotic Systems: Advances in Fabrication Strategies and Future Trends

Advanced Robotics Research, EarlyView.
Collectively, this review systematically examines 3D‐printed soft robotics, encompassing material selections, function integration, and manufacturing methodologies. Meanwhile, fabrication strategies are analyzed in order of increasing complexity, highlighting persistent challenges with proposed solutions.
Changjiang Liu, Bin Cui, Xumin Huang, Xiaoyu (Rayne) Zheng, T. Thang Vo‐Doan, Ruirui Qiao   +5 more
wiley   +1 more source

MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma

Journal of Lipid Research, 2013
Lipoprotein oxidation plays an important role in pathogenesis of atherosclerosis. Oxidized low density lipoprotein (OxLDL) induces profound inflammatory responses in vascular cells, such as production of monocyte chemoattractant protein-1 (MCP-1 ...
Philipp Wiesner, Maria Tafelmeier, Dominik Chittka, Soo-Ho Choi, Li Zhang, Young Sup Byun, Felicidad Almazan, Xiaohong Yang, Navaid Iqbal, Punam Chowdhury, Alan Maisel, Joseph L. Witztum, Tracy M. Handel, Sotirios Tsimikas, Yury I. Miller   +14 more
doaj   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes and periodontitis

Indian Journal of Endocrinology and Metabolism, 2014
Introduction: The role of serum Monocyte Chemoattractant Protein-1 (MCP-1) as a biomarker of periodontitis is well documented; however, its role in diabetic patients with periodontitis is unknown.
Preethi Radhakrishnan, Padma Srikanth, Krishna G Seshadri, Ramya Barani, Maitreya Samanta   +4 more
doaj   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

URO-MCP-1 mice exhibit bladder hypersensitivity and develop bladder inflammation upon intravesical administration of a single sub-noxious dose of LPS.

, 2016
(A) URO-MCP-1 mice develop bladder histopathology after cystitis induction. The bladders of both C57BL/6 (n = 7) and URO-MCP-1 mice (n = 8) were instilled with 100 μl PBS (top panel) or 1 μg of LPS in 100 μl PBS (bottom panel).
Susan Lutgendorf (3185328), Michael O'Donnell (99149), Suming Xu (3185322), Yaoqin Wang (3185334), Yi Luo (143206), Catherine Bradley (148981), Andrew Schrepf (3185331), Xu Wang (28596), Karl Kreder (3185325)   +8 more
core   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

MCP-1 mRNA Expression in Basal Keratinocytes of Psoriatic Lesions

, 1993
In addition to hyperproliferation of keratinocytes, psoriasis is characterized by pronounced leukocytic infiltration. In contrast to the epidermal localization of neutrophils and T lymphocytes, macrophages are almost exclusively restricted to the dermal ...
Müller, Christoph, Dan. Tong, Georg Stingl, Gillitzer, Reinhard, Rudolf Berger, Tong, Dan., Stingl, Georg, Albert A Hartmann, Reinhard Gillitzer, Teizo Yoshimura, Tong, Dan, Klaus Wolff, Yoshimura, Teizo, Christoph Müller, Wolff, Klaus, Hartmann, Albert A, Berger, Rudolf   +16 more
core   +1 more source