Results 41 to 50 of about 317,690 (321)

Preparation, chemical structure, and immunostimulatory activity of a water-soluble heteropolysaccharide from Suillus granulatus fruiting bodies

Food Chemistry: X, 2022
A water-soluble heteropolysaccharide (SGP2-1) was purified from Suillus granulatus fruiting bodies by anion-exchange chromatography and gel permeation chromatography.
Xiong Gao, Ranhua Zeng, Chi-Tang Ho, Bin Li, Shaodan Chen, Chun Xiao, Huiping Hu, Manjun Cai, Zhongzheng Chen, Yizhen Xie, Qingping Wu   +10 more
doaj  

DPHB, a diarylheptane from Alpinia officinarum Hance, ameliorates insulin resistance: A network pharmacology and in vitro study

Frontiers in Pharmacology, 2022
(4E)-7-(4-Hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB) derived from A. officinarum Hance has been reported to exert anti-inflammatory and anti-insulin resistance (IR) effects. We explored the molecular mechanism of DPHB ameliorating IR through
Xiangyi Li, Huan Wen, Yuxin Zhang, Aixia Liu, Xuguang Zhang, Minghai Fu, Yipeng Pan, Jian Xu, Junqing Zhang   +8 more
doaj   +1 more source

The recruitment and activation of phosphatidylinositol 4-phosphate 5-kinases α critically regulate CD28-dependent signaling responses [PDF]

, 2013
CD28 costimulatory receptor is a crucial determinant of the outcome of T lymphocyte activation. The engagement of CD28 by its natural ligands, B7.1/CD80 or B7.2/CD86, expressed on the surface of professional APC, lowers T cell receptor (TCR) activation ...
Camperio, Cristina, Capuano, Cristina, Caristi, S., Galandrini, R., Muscolini, Michela, Piccolella, Enza, Tuosto, Loretta   +6 more
core   +1 more source

Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer

Open Biology
Exomer is a protein complex that facilitates trafficking between the Golgi and the plasma membrane (PM). Schizosaccharomyces pombe exomer is composed of Cfr1 and Bch1, and we have found that full activation of the cell integrity pathway (CIP) in response
Esteban Moscoso-Romero, Sandra Moro, Alicia Duque, Francisco Yanguas, M.-Henar Valdivieso   +4 more
doaj   +1 more source

Phosphatidylinositol 3-kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities. [PDF]

, 2019
BackgroundThe phosphatidylinositol 3-kinase (PI3K) pathway is frequently altered in cancer. This report describes the landscape of PI3K alterations in solid tumors as well as co-alterations serving as potential resistance/attenuation mechanisms ...
Albacker, Lee, Ali, Siraj M, Jardim, Denis L, Kurzrock, Razelle, Miller, Vincent A, Millis, Sherri Z, Ross, Jeffrey S   +6 more
core   +1 more source

Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells

Food Science and Human Wellness, 2023
Dietary flavonoids are abundant in natural plants and possess multiple pharmacological and nutritional activities. In this study, apigenin, luteolin, and baicalein were chosen to evaluate their anti-diabetic effect in high-glucose and dexamethasone ...
Lingchao Miao, Haolin Zhang, Meng Sam Cheong, Ruting Zhong, Paula Garcia-Oliveira, Miguel A. Prieto, Ka-Wing Cheng, Mingfu Wang, Hui Cao, Shaoping Nie, Jesus Simal-Gandara, Wai San Cheang, Jianbo Xiao   +12 more
doaj  

Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1. [PDF]

PLoS ONE, 2014
Combination antiretroviral therapy (cART) can effectively suppress HIV-1 replication, but the latent viral reservoir in resting memory CD4(+) T cells is impervious to cART and represents a major barrier to curing HIV-1 infection.
Geneviève Doyon, Michele D Sobolewski, Kelly Huber, Deborah McMahon, John W Mellors, Nicolas Sluis-Cremer   +5 more
doaj   +1 more source

Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. [PDF]

, 2001
Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the ...
Chiang, SH, Kanzaki, M, Macara, IG, Mora, S, Pessin, JE, Saltiel, AR, Shigematsu, S, Watson, RT   +7 more
core   +3 more sources

Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo [PDF]

, 2007
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in endothelial cell survival and angiogenesis in vitro as well as in vivo.
Alavi A, Barbara Walzog, Bennett AM, Brooks PC, Chan RJ, Chang F, Chen J, Christian Plank, Crompton T, Cunnick JM, Distler JH, Florian Krötz, Frisch SM, Hadari YR, Hae-Young Sohn, Hanna Mannell, Hu Y, Huang P, Ivins Zito C, Kontaridis MI, Krotz F, Krotz F, Krotz F, Krotz F, Leopold Groesser, Munoz-Chapuli R, Neel BG, Neel BG, Nicole Hellwig, Noguchi T, Nor JE, Ong SH, O’Brien CD, Papetti M, Plank C, Qi JH, Qi JH, Qu CK, Ren Y, Saxton TM, Shi ZQ, Slater EP, Tang TL, Thakker GD, Tomanek RJ, Torsten Gloe, Ulrich Pohl, Wu CJ, Yart A, Zhang SQ, Zhang SQ   +50 more
core   +1 more source

Supplementary Figure Legends 1-4 from Ras Transformation of RIE-1 Cells Activates Cap-Independent Translation of Ornithine Decarboxylase: Regulation by the Raf/MEK/ERK and Phosphatidylinositol 3-Kinase Pathways [PDF]

, 2023
Sofia Origanti, Lisa M. Shantz
openalex   +2 more sources