Differences in oxylipin profile in psoriasis versus psoriatic arthritis [PDF]
, 2021 Funding: This work was supported by the National Institutes of Health (R01AR073324 to MG, P30DK063491 to OQ, T32AR064194 to RC, 1R01AR0690000-01 to CR).Oxylipins are biological lipids that have been implicated in inflammation.
Aaron, Armando +8 more
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Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids. [PDF]
, 2020 In the brain, approximately 90% of oxylipins are esterified to lipids. However, the significance of this esterification process is not known. In the present study, we (1) validated an aminopropyl solid phase extraction (SPE) method for separating ...
Bazinet, Richard P +7 more
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Regioselective Dehydration of Sugar Thioacetals under Mild Conditions [PDF]
, 2021 Sugars are abundant in waste biomass, making them sustainable chiral building blocks for organic synthesis. The demand for chiral saturated heterocyclic rings for pharmaceutical applications is increasing as they provide well-defined three-dimensional ...
Goyder, A +4 more
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Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils. [PDF]
, 1979 Incubation of [3H]arachidonic acid with the 17,000-g supernatant from homogenates of human neutrophils in the presence of indomethacin generated the unique metabolites 9-OH-5,7,11,14-eicosatetraenoic acid (9-HETE) and 8-HETE, in addition to 12-HETE, 11 ...
Goetzl, EJ, Sun, FF
core
The new calcium antagonist lercanidipine and its enantiomers affect major processes of atherogenesis in vitro: is calcium entry involved? [PDF]
, 1998 Atherosclerosis results from multiple factors and involves several mechanisms, including endothelial monocyte and smooth muscle cell (SMC) changes, cholesterol accumulation, plaque rupture and thromboembolism.
A. Sartani +8 more
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Journal of Biological Chemistry, 1991 Eicosanoids containing a 12-hydroxyl group preceded by at least two conjugated double bonds are metabolized to 10,11-dihydro and 10,11-dihydro-12-oxo products by porcine polymorphonuclear leukocytes (PMNL) (Wainwright, S. L., Falck, J. R., Yadagiri, P., and Powell, W. S. (1990) Biochemistry 29, 10126-10135). These 10,11-dihydro metabolites could either
S L, Wainwright, W S, Powell
openaire +2 more sources
Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation [PDF]
, 2022 Oxylipins are potent biological mediators requiring strict control, but how they are removed en masse during infection and inflammation is unknown. Here we show that lipopolysaccharide (LPS) dynamically enhances oxylipin removal via mitochondrial β ...
Luke Davies
core +1 more source
Increased leukotriene C 4 and vasogenic edema surrounding brain tumors in humans [PDF]
, 1986 Leukotrines are pharmacologically active compounds that promote vascular permeability. In this study we sought to determine whether tissue leukotriene–like immunoreactivity was increased in intracranial tumors associated with peritumoral edema.
Black, Keith L. +3 more
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Drug discovery targeting non-amyloid pathways in Alzheimer’s disease [PDF]
, 2020 Alzheimer’s disease (AD) is the most common form of dementia with almost 50 million people affected and unfortunately, no cure or treatment to halt the disease progression is available.
Dahlström, Märta
core +1 more source
The metabolomics of psoriatic disease. [PDF]
, 2017 Metabolomics is an emerging new "omics" field involving the systematic analysis of the metabolites in a biologic system. These metabolites provide a molecular snapshot of cellular activity and are thus important for understanding the functional changes ...
Afifi, Ladan +6 more
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