Results 81 to 90 of about 250,877 (332)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The gyrB gene is a useful phylogenetic marker for exploring the diversity of flavobacterium strains isolated from terrestrial and aquatic habitats in Antarctica [PDF]

, 2011
Within the phylum Bacteroidetes, the gyrB gene, encoding for the B subunit of the DNA gyrase, has been used as phylogenetic marker for several genera closely related to Flavobacterium.
Peeters, Karolien, Willems, Anne
core   +1 more source

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

Advanced Healthcare Materials, EarlyView.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira, Sylvie Ribeiro, Senentxu Lanceros‐Mendez, Clarisse Ribeiro   +3 more
wiley   +1 more source

Clostridium sordellii Brain Abscess Diagnosed by 16S rRNA Gene Sequencing [PDF]

Journal of Clinical Microbiology, 2010
ABSTRACT Clostridium sordellii is usually associated with skin and soft tissue infections. We describe the first case to our knowledge of a Clostridium sordellii -associated brain abscess, diagnosed by 16S rRNA gene sequencing, expanding the microbiological spectrum of brain abscesses, with ...
F, Valour, S, Boisset, L, Lebras, B, Martha, A, Boibieux, T, Perpoint, C, Chidiac, T, Ferry, D, Peyramond   +8 more
openaire   +2 more sources

Time series genome-centric analysis unveils bacterial response to operational disturbance in activated sludge [PDF]

, 2019
Understanding ecosystem response to disturbances and identifying the most critical traits for the maintenance of ecosystem functioning are important goals for microbial community ecology.
Erijman, Leonardo, Figuerola, Eva Lucia Margarita, Guerrero, Leandro Demián, Orellana, Esteban, Pérez, María Victoria   +4 more
core   +1 more source

High‐Throughput 3D Matrigel‐based Droplet Microfluidics for Single‐Cell Function‐to‐Omics Analysis of Cytotoxic Immune Cells in Solid Tumor Interactions

Advanced Materials Technologies, EarlyView.
A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey, Harry Akligoh, Michael Finocchiaro, Abhishek Srihari Rampelli, Zongwei Wang, Aria F. Olumi, Tania Konry   +6 more
wiley   +1 more source

Rapid and reliable species-level identification from clinical samples using 16S rRNA gene nanopore sequencing analysis

Scientific Reports
The detection and identification of bacterial species in clinical samples are crucial for patient management and antibiotic treatment. When culture-based identification methods fail, 16S rRNA gene next-generation sequencing (NGS) serves as a valuable ...
Marco J. R. Ivens, Sergio Kamminga, Kawtar Benchamach, Chaimae Akile, Els Wessels, Eric C. J. Claas, Stefan A. Boers   +6 more
doaj   +1 more source

Capturing Greater 16S rRNA Gene Sequence Diversity within the Domain Bacteria [PDF]

Applied and Environmental Microbiology, 2012
ABSTRACT A large proportion of “universal” 16S PCR primers lack sequence homology to many of the “candidate” divisions, severely limiting bacterial diversity assessments. We designed a primer set that offers a 50% increase in silico in coverage of the domain Bacteria over the ...
T, Winsley, J M, van Dorst, M V, Brown, B C, Ferrari   +3 more
openaire   +2 more sources

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Limitations of 16S rRNA Gene Sequencing to Characterize Lactobacillus Species in the Upper Genital Tract

Frontiers in Cell and Developmental Biology, 2021
The endometrial cavity is an upper genital tract site previously thought as sterile, however, advances in culture-independent, next-generation sequencing technology have revealed that this low-biomass site harbors a rich microbial community which ...
Jessica L. O’Callaghan, Jessica L. O’Callaghan, Dana Willner, Dana Willner, Melissa Buttini, Flavia Huygens, Flavia Huygens, Elise S. Pelzer, Elise S. Pelzer   +8 more
doaj   +1 more source