Results 171 to 180 of about 46,711 (243)

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

The Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin, Andrea Carrer, Federica Boscolo Nata, Elena Frigo, Federico Fogolari, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +7 more
wiley   +1 more source

Mitochondrial permeability transition in skeletal muscle phenocopies muscle alterations seen in cancer cachexia and other wasting conditions

The Journal of Physiology, EarlyView.
Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel, Cole Lukasiewicz, Sarah Skinner, Mark R. Viggars, Sung Gi Noh, Martin Picard, Abbey‐Gale Mannings, Michael S. Cohen, Dennis W. Wolan, Terence E. Ryan, Russell T. Hepple   +10 more
wiley   +1 more source

Novel diazene-tri(phenoxy-1,2,3-triazole-acetamide) derivatives as potent α-glucosidase inhibitors: synthesis, biological evaluation, and <i>in silico</i> studies. [PDF]

RSC Adv
Kermaninia S, Sayahi MH, Halimi M, Mirjalili SZ, Mohammadi H, Abbasi AA, Mojtabavi S, Sepehri N, Hamedifar H, Larijani B, Mohammadi-Khanaposhtani M, Mahdavi M.   +11 more
europepmc   +1 more source

Legacy hexaconazole and tricyclazole residues hinder organic transition in paddy rice cultivation

Agricultural &Environmental Letters, Volume 11, Issue 2, December 2026.
Hexaconazole and tricyclazole residues persisted in paddy soil throughout the three consecutive growing seasons after a single foliar application. These findings, combined with potential animal feed risks from contaminated rice straw, indicate that the current 2‐year organic transitional period is insufficient, necessitating extended conversion periods
Suin Cho, Hye‐In Joe, Tae‐Hwa Kim, Jong‐Woo Park, Byeong‐Jin Bae, Byeung‐Kon Shin, Jeong‐In Hwang   +6 more
wiley   +1 more source

Structure-activity relationships of quinoidal derivatives against <i>Trypanosoma brucei</i>. [PDF]

Results Chem
Machado LA, Francisco KR, Almeida RG, Uli Sun Y, Shingyoji M, Mercer AM, Lopez IG, Ferreira RS, Jardim GAM, Caffrey CR, da Silva Júnior EN.   +10 more
europepmc   +1 more source

Real‐World Survival Outcomes of Venetoclax Combination Therapies in Acute Myeloid Leukemia: Impact of Minimal Residual Disease Status and Antifungal Prophylaxis

Hematological Oncology, Volume 44, Issue 6, November 2026.
ABSTRACT In recent years the addition of the oral BCL2 inhibitor venetoclax to hypomethylating agents (HMAs) has emerged as the standard‐of‐care for patients with acute myeloid leukemia (AML) who are not fit for intensive chemotherapy, significantly improving survival and quality‐of‐life.
Mariarita Sciumè, Alessandro Bosi, Alfredo Marchetti, Fabio Serpenti, Pasquale De Roberto, Sonia Fabris, Francesco Versino, Elena Tagliaferri, Francesco Passamonti, Nicola Stefano Fracchiolla   +9 more
wiley   +1 more source

Rate-controlled intravenous voriconazole rapid desensitization in a patient with chronic pulmonary aspergillosis and triazole hypersensitivity. [PDF]

IDCases
Yasue E, Ogawa T, Mano Y, Takeuchi T, Harada K, Kimizuka Y.   +5 more
europepmc   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Triazole-Based Metal-Organic Frameworks for CO₂ Capture. [PDF]

Nanomaterials (Basel)
Nabipour H, Rohani S.
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source