Results 171 to 180 of about 44,670 (249)

2-Pyrazoline-5-One Derivative Suppresses Cell Proliferation and Induces Apoptosis With Upregulation of Bax in Breast Cancer Cells. [PDF]

J Biochem Mol Toxicol
Sevinc SK, Küçükgüzel ŞG, Rollas S, Yukcu F.   +3 more
europepmc   +1 more source

Gingival enlargement and dentition loss associated with disseminated Cryptococcus neoformans infection in a dog

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract A 1‐year‐old, female, spayed, mixed‐breed dog was examined by a referring veterinarian for a 1‐week history of sneezing, bilateral mucoid nasal discharge, mild bilateral ocular discharge and stertor. During rhinoscopy, a plant awn foreign body was removed, but upper respiratory signs persisted. Computed tomography of the head revealed findings
Glynn Woods, Allison Volk, Janny Evenhuis, Abbie Metcalfe, Jane E. Sykes   +4 more
wiley   +1 more source

Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice. [PDF]

Neuropsychopharmacology
Volf A, Brust TF, Kobylski RR, Czekner KM, Stahl EL, Cameron MD, Trojniak AE, Wood AB, Aubé J, Bohn LM.   +9 more
europepmc   +1 more source

Accumulation of Histidine Reduce the Susceptibility of Vibrio splendidus Persister Cells to Tetracycline

Environmental Microbiology Reports, Volume 18, Issue 4, August 2026.
Histidine accumulation promotes tetracycline‐induced persister formation in V. splendidus. It enhances membrane potential and upregulating the efflux pump gene, thereby reducing antibiotic susceptibility. ABSTRACT Vibrio splendidus is an opportunistic pathogen widely distributed in marine environments, animal tissues and seabed sediments. It can infect
Yanan Li, Xinnan Pan, Jiayao Chen, Hong Ding, Yina Shao   +4 more
wiley   +1 more source

Design and Synthesis of Bis-Triazole-Linked Benzenesulfonamides as Selective Carbonic Anhydrase IX/XII Inhibitors with Chemosensitizing Activity. [PDF]

J Med Chem
Roshdy E, Kilic A, Mustafa M, Celik I, Sarı ZB, Simsek E, Nocentini A, Giovannuzzi S, Supuran CT, Özensoy Güler Ö, Winum JY, Abe M.   +11 more
europepmc   +1 more source

Reaction Enumeration Based on NBO‐Informed Molecular Graphs

Journal of Computational Chemistry, Volume 47, Issue 19, 15 July 2026.
NBO‐informed molecular graphs represent chemistry via valence orbitals rather than atomic connectivity, enabling consistent reaction analysis across environments. By identifying delocalized motifs and increasing complexity adaptively, the framework enables efficient exploration of inaccessible mechanisms and diverse catalytic and reaction networks for ...
Javier E. Alfonso‐Ramos, Thijs Stuyver
wiley   +1 more source

β-Mannosyl Triazoles as Mimics of Galactosyl Galectin-3 and Galectin-9 N-Terminal Domain Inhibitors. [PDF]

Chembiochem
Sjövall F, Nilsson UJ.
europepmc   +1 more source

Oligonucleotides Post‐Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid‐Phase Synthesis

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Clickable nucleoside phosphoramidites can be incorporated into oligonucleotides via solid‐phase synthesis (SPOS), enabling rapid and site‐specific post‐functionalization using bioorthogonal reactions. This review highlights their design, synthetic accessibility, and SPOS incorporation requirements, along with the kinetics and efficiency of post ...
Sébastien Depienne, Alexandra Bristiel, Dominique Urban, Dominique Guianvarc’h   +3 more
wiley   +1 more source

Superprotonic conductivity in crystalline and amorphous framework materials under anhydrous conditions. [PDF]

Chem Sci
Ma N.
europepmc   +1 more source

Mutasynthesis and Antibiotic Activity of Mupirocin Analogues

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
A mutasynthetic strategy was developed to prepare pseudomonic acid analogues, and their antimicrobial activities were evaluated against five bacterial strains. Feeding studies with mutant strains of Pseudomonas fluorescens revealed that C7‐desepoxy‐PA‐B was metabolised to C7‐PA‐C with loss of the 8‐hydroxyl group, but no fatty acid chain extension ...
Sarah M. Husain, Luoyi Wang, Li‐Chen Han, James I. Bowen, Zhongshu Song, Felix de Courcy‐Ireland, Ashley J. Winter, Thomas J. Simpson, Paul R. Race, James Spencer, Matthew P. Crump, Christine L. Willis   +11 more
wiley   +1 more source