Results 81 to 90 of about 44,721 (246)

Durch anomere Amide ermöglichte divergente Synthese unsymmetrischer Harnstoffe, Carbamate, Thioester und Amide aus Aldehyden

Angewandte Chemie, EarlyView.
Eine divergente Aldehyd‐Funktionalisierungssequenz, ermöglicht durch ein anomeres Amid, erlaubt den Ein‐Topf‐Zugang zu unsymmetrischen Harnstoffen, Carbamaten, Thiocarbamaten, Thioestern und Amiden. Entscheidend für diese Transformation ist die Bildung von N‐Boc‐Hydroxamat‐Intermediaten, die als Plattformen für eine orthogonale Aktivierung über Lossen ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Sodium 2-(4-amino-(5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate, synthesis, study of biochemical indicators of blood serum cows in its use

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Introduction. Heterocyclic system of 1,2,4-triazole is interesting and has a popularity among scientists around the world every year. Most attention today is attracted to the compounds formed by a combination of 1,2,4-triazole and various structural ...
D. M. Danilchenko, T. V. Zvenigorodska, V. V. Parchenko   +2 more
doaj   +1 more source

Computer prediction of acute toxicity of thioderivatives of 3,5-bis(5-mercapto-4-R-4H-1,2,4-triazol-3-yl)phenol

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
This study presents the computational prediction of acute toxicity for new derivatives of 3,5-bis(5-mercapto-4-R-4H-1,2,4-triazol-3-yl)phenols and their alkylated analogues.
K. K. Isaicheva, A. H. Kaplaushenko
doaj   +1 more source

Cytotoxic, DNA Cleavage and Pharmacokinetic Parameter Study of Substituted Novel Furan C-2 Quinoline Coupled 1, 2, 4-Triazole and Its Analogs. [PDF]

Open Med Chem J, 2018
Anantacharya R, Satyanarayan ND, Sukhlal Kalal B, Pai VR.   +3 more
europepmc   +2 more sources

Corrosion inhibition of brass 60Cu-40Zn in 3% NaCl solution by 3-amino-1, 2, 4-triazole-5-thiol. [PDF]

Heliyon, 2020
Damej M, Chebabe D, Abbout S, Erramli H, Oubair A, Hajjaji N.   +5 more
europepmc   +1 more source

A Fixed‐Charge Interphase Synchronizes Ion Transport to Suppress Space‐Charge‐Driven Inefficiency Under Nanoliter Confinement

Angewandte Chemie International Edition, EarlyView.
Electrochemical energy storage breaks down under extreme miniaturization, where interfaces and space‐charge dominate device behavior. This work introduces a fixed‐charge selective interphase (FCSI) integrated into a twin‐tube micro‐Swiss‐roll architecture.
Yaping Yan, Jiachen Ma, Wenlan Zhang, Hongmei Tang, Yue Li, Ruhuai Mei, Yang Huang, Daniil Karnaushenko, Dmitriy D. Karnaushenko, Yumin Luo, Kai Zhang, Oliver G. Schmidt, Minshen Zhu   +12 more
wiley   +1 more source

Peptide Thioester and Triazole Derivatives Through On‐Resin Dual‐Modification of Peptide Thiosulfonates

Angewandte Chemie International Edition, EarlyView.
An on‐resin dual‐modification strategy for peptides is presented, comprising S‐alkynylation of peptide thiosulfonates and regioselective iridium‐catalyzed azide–thioalkyne cycloaddition. This method reliably provides access to peptides with intricate non‐canonical modifications, being compatible with complex peptides, alkynes and azides.
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Evaluation of antioxidant activity of 1,2,4-triazole derivatives in the initiation of free radical processes

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
The activation of lipid free radical oxidation is a key stage in the development of many diseases and can lead to the emergence of related complications.
I. M. Bilai, V. I. Dariy, A. V. Khilkovets, A. I. Bilai, I. F. Duiun   +4 more
doaj   +1 more source

Synthesis methods of 1,2,4-triazole-3-thiones: review

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
1,2,4-Triazole-containing compounds are unique heterocyclic compounds present in an array of pharmaceuticals and biologically important compounds used in drug-discovery studies against cancer cells, microbes, and various types of diseases in the human ...
Yu. S. Frolova, A. H. Kaplaushenko, T. V. Ihnatova, T. M. Kaplaushenko   +3 more
doaj   +1 more source