Results 1 to 10 of about 38,585 (330)

Thermal Rearrangement of Allyl Substituted Unsymmetric 4H-1,2,4-Triazoles to the Corresponding 1H-1,2,4-triazoles

Molecules, 2001
A series of neat 4-(2-alkenyl) substituted 5-methyl-3-phenyl-4H-1,2,4-triazoles were thermolyzed at 320 oC producing a rearrangement products, of which the regioisomeric 1- and 2-substituted triazoles were the main products.
Per H.J. Carlsen, Ragnhild B. Olsen, KÃ¥re B. Jørgensen   +2 more
doaj   +1 more source

Novel allyl-hydrazones including 2,4-dinitrophenyl and 1,2,3-triazole moieties as optical sensor for ammonia and chromium ions in water

BMC Chemistry, 2022
It is critical to take safety action if carcinogenic heavy metals and ammonia can be detected quickly, cheaply, and selectively in an environmental sample. As a result, compound 4a [4-(1-(2-(2,4-Dinitrophenyl)hydrazineylidene)-3-(naphthalen-2-yl)allyl)-5-
Hanan A. Mohamed, Bakr F. Abdel-Wahab, Mahmoud N. M. Yousif, Reda M. Abdelhameed   +3 more
doaj   +1 more source

Some transformations and physicochemical properties of new S-substituted 5-thiophene-(3-ylmethyl)-4R-1,2,4-triazole-3-thiols

Фармацевтичний журнал, 2021
Nitrogen-containing heterocyclic compounds are widely represented in modern organic chemistry. A special place among the huge number of substances presented is occupied by derivatives of 1,2,4-triazole due to their uniqueness and prospects.
A. V. Khilkovets
doaj   +1 more source

Coordinatively unsaturated ruthenium complexes as efficient alkyne-azide cycloaddition catalysts [PDF]

, 2012
The performance of 16-electron ruthenium complexes with the general formula Cp*Ru(L)X (in which L = phosphine or N-heterocyclic carbene ligand; X = Cl or OCH2CF3) was explored in azide−alkyne cycloaddition reactions that afford the 1,2,3- triazole ...
Broggi, Julie, Cavallo, Luigi, Fortman, George C., Lamberti, Marina, Nolan, Steven P., Poater, Albert, Slawin, Alexandra M. Z.   +6 more
core   +2 more sources

Anti-inflammatory and antinociceptive evaluation of newly synthesized 4-(substituted ethanoyl) amino-3-mercapto-5-(4-methoxy) phenyl-1,2,4-triazoles

Journal of Pharmacy and Bioallied Sciences, 2011
Introduction: 1,2,4-triazoles and its derivatives have been reported to possess anti-inflammatory, analgesic, antimicrobial, anticancer, antitumor, antitubercular, anticonvulsant, openers of Ca-activated potassium (Maxi-K) channels, antiviral properties,
Neeraj Upmanyu, Jeetendra Kumar Gupta, Kamal Shah, Pradeep Mishra   +3 more
doaj   +1 more source

Heterocyclizations based on N-(R-hydrazine-1-carbonothioyl)cycloalkancarboxamides: functionalized azoles and their antimicrobial activity

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
Synthesis and structural modification of azoles remains an important area of medical chemistry and allows to obtain new compounds with a wide range of biological activity.
О. V. Kholodniak, Yu. V. Shubina, S. I. Kovalenko   +2 more
doaj   +1 more source

Selected 5-amino-1-aryl-1H-1,2,3-triazole scaffolds as promising antiproliferative agents [PDF]

The Ukrainian Biochemical Journal, 2020
Development of a new effective drugs with low side effects and definite chemical characteristics needs indentification of bioactive scaffolds for further structural optimization.
N. Pokhodylo, O. Shyyka, N. Finiuk, R. Stoika   +3 more
doaj   +1 more source

Synthesis and physical-chemical properties of 3-(4-(tert-butyl)phenyl)-5-(R-ylthio)-4H-1,2,4-triazol-4-amines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Aim. 1,2,4-triazole derivatives are widely used in medical practice due to its wide range of biological effect and small toxicity. This fact makes this class of organic heterocyclic compounds especially interesting and promising for the study of their ...
I. I. Aksyonova, O. I. Panasenko, Ye. G. Knysh   +2 more
doaj   +1 more source

Synthesis of Bis (1,4-Disubstituted-1,2,3-triazoles) Starting from Diethyl Galactarate

Chemistry Proceedings, 2022
This communication reports the synthesis of a series of bis (1,4-disubstituted-1,2,3-triazoles) starting from the known (2,3,4,5) bis acetonide-protected diethyl galactarate (1).
Víctor Terraza, Darío Gerbino, Julio Podestá   +2 more
doaj   +1 more source

Synthesis and physicochemical properties 4-((R))amino)-5-methyl-4H-1,2,4-triazole-3-thiols

Фармацевтичний журнал, 2018
Purposeful synthesis of derivatives of 1,2,4-triazole is one of the most important branches of modern pharmaceutical science Modern pharmaceutical market of domestic medicines requires constant updates of existing range.
T. V. Kravchenko, O. I. Panasenko, Ye. G. Knysh   +2 more
doaj   +1 more source