Results 111 to 120 of about 38,585 (330)

Antidepressant Activity of Some Novel 1, 2, 4 Triazole Substituted Quinazoline Derivatives

International Journal of Pharmaceutical Chemistry and Analysis, 2016
Introduction: Quinazoline is an important moiety found natural and used for their biological activity, quinazoline always attract scientist due to its broad therapeutic value. In the present research article we prepared a series of fifteen compound by conjugating to prominent therapeutic active moiety to produce synergistic effect to mimic the ...
Narendra Joshi, Anju Goyal
openaire   +1 more source

C-Glycosyl 1,2,4-triazoles: Synthesis of the 3-β-d-glucopyranosyl-1,5-disubstituted and 5-β-d-glucopyranosyl-1,3-disubstituted variants [PDF]

, 2017
K
Páhi, András, Somsák, László, Szabó, Erzsébet Katalin   +2 more
core   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Synthesis of Novel Glycerol-Derived 1,2,3-Triazoles and Evaluation of Their Fungicide, Phytotoxic and Cytotoxic Activities

Molecules, 2017
The synthesis of a series of 1,2,3-triazoles using glycerol as starting material is described. The key step in the preparation of these triazolic derivatives is the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), also known as click reaction ...
Adilson Vidal Costa, Marcos Vinicius Lacerda de Oliveira, Roberta Tristão Pinto, Luiza Carvalheira Moreira, Ediellen Mayara Corrêa Gomes, Thammyres de Assis Alves, Patrícia Fontes Pinheiro, Vagner Tebaldi de Queiroz, Larissa Fonseca Andrade Vieira, Robson Ricardo Teixeira, Waldir Cintra de Jesus Júnior   +10 more
doaj   +1 more source

Chemical Structure and Herbicidal Activity of 1, 2, 4-Triazole-carboxamide Derivatives.

Journal of Weed Science and Technology, 1999
新規な1,2,4-トリアゾールカルボキサミド誘導体について, タイヌビエに対する除草活性と移植イネに対する安全性を指標として, 構造と活性を検討した。1. 雑草発生前処理高いタイヌビエ除草活性と移植イネに対する安全性を保有するには, ベンゼン環の2位と6位が低級アルキル基や塩素原子で置換されていることが必要で, とくに2,6-ジメチル置換体, 2-メチル-6-エチル置換体, 2-メチル-6-塩素置換体および2,4,6-トリメチル置換体が, 優れた除草活性とイネ安全性を示した。カルバモイル基の置換様式は, N,N-ジエチルカルバモイル体およびN-エチル, N-プロピカルバモイル体が高活性に寄与し, アルキル基がメチルあるいはブチルでは劣った。イネに対してはいずれも高い安全性を示した ...
Mitsuru Kanzaki, Masaki Takeuchi, Norio Shirakawa   +2 more
openaire   +2 more sources

Cycloadditions of cyclohexynes and cyclopentyne. [PDF]

, 2014
We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described.
Garg, Neil K, Houk, KN, Jiménez-Osés, Gonzalo, McMahon, Travis C, Medina, Jose M   +4 more
core   +2 more sources

Copper-Catalyzed Synthesis of 4-CF₃-1,2,3-Triazoles: An Efficient and Facile Approach via Click Reaction

Molecules
Incorporation of a trifluoromethyl group with 1,2,3-triazoles motifs was described. We explored a click reaction approach for regioselective synthesis of 1-susbstituted-4-trifluoromethyl-1,2,3-triazoles in which 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU ...
Tinghong Tang, Cuiting Chen, Xin Fu, Huilan Xu, Luyong Wu, Wenhao Chen   +5 more
doaj   +1 more source

Actoprotective activity of 2-(4-r-3-(thiophen-2-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid

Zaporožskij Medicinskij Žurnal, 2017
INTRODUCTION. The high temp of life, characteristic to a modern human, firmly leads to depletion of physical and mental strength. To improve the physical and mental activity of humans to normal and extreme conditions, a drugs of different origin are ...
V. O. Salionov, Ye. S. Pruglo, O. I. Panasenko   +2 more
doaj   +1 more source

Bis[3-ethyl-4-(4-methoxyphenyl)-5-(2-pyridyl)-4H-1,2,4-triazole-κ²N¹,N⁵]bis(perchlorato-κO)copper(II) acetonitrile disolvate [PDF]

, 2008
Liaocheng Huang, Zuoxiang Wang, Xiaoming Zhang, Pingfeng Wu   +3 more
openalex   +1 more source

2-(4-Arylbuta-1,3-dien- or 1-en-3-yn-1-yl)chromones as synthons for the synthesis of other nitrogen and oxygen heterocyclic compounds [PDF]

, 2014
It is well known the great biological relevance of oxygen and nitrogen heterocycles. Herein, the reactivity of 2-(4-aryl-1,3-dien- and 1-en-3-yn-1-yl)chromones are explored in order to establish new synthetic routes towards the preparation of new ...
Albuquerque, Hélio, Cavaleiro, José, Santos, Clementina M.M., Silva, Artur   +3 more
core