Results 181 to 190 of about 25,343 (252)

Structure-Property Correlations in Disubstituted 1,2,3-Triazoles: DFT Insights and Photophysical Analysis. [PDF]

ACS Omega
Lakhani D, Sadiq S, Subbaiahgari H, Swanson V, Munyon J, Poudel SB, Aiken KS, Landge SM, Bose D, Ghosh D.   +9 more
europepmc   +1 more source

Mutasynthesis and Antibiotic Activity of Mupirocin Analogues

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
A mutasynthetic strategy was developed to prepare pseudomonic acid analogues, and their antimicrobial activities were evaluated against five bacterial strains. Feeding studies with mutant strains of Pseudomonas fluorescens revealed that C7‐desepoxy‐PA‐B was metabolised to C7‐PA‐C with loss of the 8‐hydroxyl group, but no fatty acid chain extension ...
Sarah M. Husain, Luoyi Wang, Li‐Chen Han, James I. Bowen, Zhongshu Song, Felix de Courcy‐Ireland, Ashley J. Winter, Thomas J. Simpson, Paul R. Race, James Spencer, Matthew P. Crump, Christine L. Willis   +11 more
wiley   +1 more source

Synthesis and Pharmacological Evaluation of Novel 1,5-Disubstituted-3-amino-1,2,4-triazoles Designed as Multitarget Directed Ligands for Alzheimer's Disease Targets. [PDF]

ACS Omega
Franco DP, Caruso L, Grillo DCN, Nadur NF, de Azevedo LL, Pereira TM, da Silva MC, Lacerda RB, Pinheiro PSM, Riger CJ, Kümmerle AE.   +10 more
europepmc   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source

Coumarin-1,2,4-Triazole hybrids as potential agents against Brassicogethes aeneus (Fabricius 1775). [PDF]

Sci Rep
Šubarić D, Rastija V, Molnar M, Sarajlić A, Babić MK, Kovačić M, Puškadija Z, Majić I.   +7 more
europepmc   +1 more source

Synthetic Ligands of Myeloid C‐Type Lectin Receptors

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley   +1 more source

In vitro and clinical data demonstrate negligible risk of drug-drug interactions with opelconazole, a novel inhaled antifungal agent. [PDF]

J Antimicrob Chemother
Cass LMR, Ayrton J, Brüggemann RJ, Moore J, Martin U, Grey L, Hyman M, Berman L.   +7 more
europepmc   +1 more source

Toward Sustainable Carbonylation Reactions Enabled by CO Surrogates in Green Solvents

ChemSusChem, Volume 19, Issue 13, 14 July 2026.
Carbonylation reactions offer a sustainable route to valuable carbonyl compounds. This review highlights methodologies that exploit carbonylative coupling to drastically enhance process sustainability, avoiding the direct use of CO through CO surrogates and promoting syntheses in green solvents potentially derived from renewable and sustainable sources.
Francesco Messa, Serena Perrone, Antonio Salomone   +2 more
wiley   +1 more source

Updates on Chromoblastomycosis: Evolving Insights in Clinical Management and Therapeutic Strategies. [PDF]

Curr Fungal Infect Rep
Popovic K, Henao-Martínez AF, Teixeira MM, de Souza EBA, Rakotoarisaona M, Agudelo Higuita NI.   +5 more
europepmc   +1 more source

The Solid‐State Emission of AIPE‐Active Tricarbonylrhenium(I) Complexes Shifts to the Red: The Unexpected Performance of Triphenylphosphine Derivatives

Aggregate, Volume 7, Issue 7, July 2026.
New phosphino tricarbonylrhenium(I) complexes have efficient red emission in the aggregate and solid states. The good photostability and the vast possibilities of chemical modifications make these Re‐based complexes the starting point of a new generation of red emitters with aggregation‐induced phosphorescence emission (AIPE) characteristics.
Valentine Guilbaud, Mariusz Wolff, Maëlle Deleuzière, Evelyne Delfourne, Corinne Vanucci‐Bacqué, Charles‐Louis Serpentini, Sonia Mallet‐Ladeira, Eric Benoist, Suzanne Fery‐Forgues   +8 more
wiley   +1 more source