Results 71 to 80 of about 97,768,553 (154)

2’-Fucosyllactose Ameliorates Chemotherapy-Induced Intestinal Mucositis by Protecting Intestinal Epithelial Cells Against ApoptosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Intestinal mucositis, a severe complication of antineoplastic therapeutics, is characterized by mucosal injury and inflammation in the small intestine. Therapies for the prevention and treatment of this disease are needed.
Gang Zhao, Jessica Williams, M. Kay Washington, Yaohua Yang, Jirong Long, Steven D. Townsend, Fang Yan   +6 more
doaj   +1 more source

High-Level De Novo Biosynthesis of 2′-Fucosyllactose by Metabolically Engineered Escherichia coli

, 2022
2′-Fucosyllactose (2′-FL) is the most abundant oligosaccharide in human milk. In this study, a highly efficient biosynthetic route for 2′-FL production was designed via the de novo pathway of GDP-l-fucose using engineered Escherichia coli BL21­(DE3 ...
Li Wan (11826), Roulin Chen (13046521), Yuanlin Liu (6369383), Yingying Zhu (331728), Wanmeng Mu (408651), Wenli Zhang (146408)   +5 more
core   +1 more source

Ovalbumin-Induced Epithelial Activation Directs Monocyte-Derived Dendritic Cells to Instruct Type 2 Inflammation in T Cells Which Is Differentially Modulated by 2′-Fucosyllactose and 3-Fucosyllactose

Journal of Innate Immunity, 2022
Allergic sensitization starts with epithelial cell activation driving dendritic cells (DCs) to instruct T helper 2 (Th2) cell polarization. Food allergens trigger intestinal epithelial cell (IEC) activation.
Marit Zuurveld, Pien C.J. Kiliaan, Sophie E.L. van Grinsven, Gert Folkerts, Johan Garssen, Belinda van’t Land, Linette E.M. Willemsen   +6 more
doaj   +1 more source

The Impact of Oral‐Gut Microbiota Structure and Its Manipulation on RA Development and Management

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
(A) Schematic representation of oral–gut microbiota composition in health and rheumatoid arthritis (RA), highlighting the enrichment of beneficial microorganisms (green) under healthy conditions and the expansion of pathogenic microorganisms (orange) in RA‐associated dysbiosis.
Parisa Ahmadi, Mahmoud Mahmoudi, Sina Mozaffari‐Jovin, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Samaneh Mollazadeh, Jafar Hajavi, Hanieh Kolahdooz, Seyed‐Alireza Esmaeili   +8 more
wiley   +1 more source

2′‐FL's Depiction of the Human Physiological Function Landscape

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The figure summarizes the multifaceted physiological effects of 2′‐fucosyllactose (2′‐FL), a major human milk oligosaccharide. The schematic illustrates the central role of the gut‐centered regulatory axis, where 2′‐FL modulates gut microbiota composition, promotes the production of short‐chain fatty acids and microbial metabolites, enhances mucus ...
Yushan Xiao, Jiahao Li, Xiaofeng Li, Yan Dai   +3 more
wiley   +1 more source

Maternal and infant gut microbiome

iMeta, Volume 5, Issue 4, August 2026.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Metabolic interactions and growth dynamics of Bifidobacterium strains in response to human milk oligosaccharides and lactose

Frontiers in Microbiology
Bifidobacteria are major representatives of the intestinal microbiota in infants typically identified as characteristic of healthy breastfed infants. Their establishment is driven by the presence of carbohydrates, namely human milk oligosaccharides (HMOs)
Stefan Ratering, Sylvia Schnell, Christian Borsch, Sinéad T. Morrin, David R. Hill, Rachael H. Buck, Silvia Rudloff, Silvia Rudloff   +7 more
doaj   +1 more source

Mass Spectrometry and NMR Spectroscopy‐Based Structural Characterization of Polysaccharide From Gastrodia elata Blume

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Structural characterization of complex carbohydrates remains challenging. This study employed methylation, acid hydrolysis, 1‐phenyl‐3‐methyl‐5‐pyrazolone (PMP) derivatization, and ultra‐high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) to determine monosaccharides, glycosidic linkages, and sequence of ...
Hui Yan, Cheng‐Xi Feng, Zhe Wang, Jun‐Qiao Wang, Shao‐Ping Nie   +4 more
wiley   +1 more source

Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 829-850, July/August 2026.
ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song, HyunJi Lee, Youngshik Choe, Hyeyoung Lee   +3 more
wiley   +1 more source

Human Milk Bioactive Compounds and Psychomotor Outcomes in Infants and Children: A Systematic Review

Molecular Nutrition &Food Research, Volume 70, Issue 14, 29 July 2026.
In our review, we assess the role of HM fatty acids, oligosaccharides, proteins, and carotenoids, on psychomotor development in children up to 18 years. Findings suggest that HM BCs, particularly n‐3 PUFAs and fucosylated HMOs, might contribute to a favorable psychomotor development in infancy, preschool age, and school age.
Lara Huber, Eduard Flores Ventura, Regina Ensenauer, Daria Guseva   +3 more
wiley   +1 more source