Results 181 to 190 of about 18,068,740 (214)

2-Hydroxypropyl-beta-cyclodextrin increases aqueous solubility and photostability of all-trans-retinoic acid

Journal of Clinical Pharmacy and Therapeutics, 2000
All-trans-retinoic acid (ATRA, vitamin A acid or tretinoin) is effective in the treatment of acute promyelocytic leukaemia (APL). Unfortunately, the oral absorption of ATRA is highly variable. Its poor aqueous solubility also makes it difficult to be formulated into parenteral formulation.
H S, Lin, C S, Chean, Y Y, Ng, S Y, Chan, P C, Ho   +4 more
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Effects of 2-hydroxypropyl-beta-cyclodextrin on pharmacokinetics of digoxin in rabbits and humans.

Die Pharmazie, 2004
Considering the narrow therapeutic index of digoxin and the low range between the safe and toxic serum concentrations of this drug, to evaluate the relative bioavailability of tablets and oral solution is necessary. The pharmacokinetic properties of digoxin after oral administration of its hydroxypropyl-beta-cyclodextrin (HPCD) inclusion complex to ...
Z G, He, Y S, Li, T H, Zhang, X, Tang, C, Zhao, R H, Zhang   +5 more
openaire   +1 more source

Solubilization of ovine growth hormone with 2-hydroxypropyl-beta-cyclodextrin.

Journal of parenteral science and technology : a publication of the Parenteral Drug Association, 1992
Studies were undertaken to determine the effects of 2-hydroxypropyl-beta-cyclodextrin (HPCD) on the solubility of ovine-Growth Hormone (o-GH) in aqueous solution. HPCD, which is believed to form inclusion complexes with hydrophobic amino acid residues of peptides, markedly increased o-GH solubility at all o-GH and all HPCD concentrations tested.
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MECHANISM OF FORMATION OF “GUEST-HOST” COMPLEXES BETWEEN RUTIN AND 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN

Lomonosov chemistry journal
ATR-FTIR and NMR spectroscopy were used to investigate the mechanism of plant antioxidants’ interactions with 2-hydroxypropyl-beta-cyclodextrin, using rutin as an example. Rutin is characterized by the aromatic skeleton’s incorporation into the cyclodextrin torus and stabilization brought about by the interaction between the cyclodextrin’s –OH groups ...
Irina Le-Deygen, Thi Lan Pham, Anna Skuredina, Pavel Markov, Van Cuong Bui, Thi My Hanh Le, Hoang Trang Nguyen, Tatyana Savitskaya   +7 more
openaire   +1 more source

Complexation Study of the Anticancer Agent EO-9 with 2-hydroxypropyl-β-Cyclodextrin

Drug Development and Industrial Pharmacy, 2008
For the development of a bladder instillation of the indoloquinone agent EO-9, use of the complexing agent 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) was considered. Therefore, a complexation study of EO-9 with HPbetaCD was performed. Complexation was studied in aqueous solution and in solid freeze-dried products. A phase solubility study, UV-visible
Beijnen, J.H., van der Schoot, S.C., Nuijen, B., Flesch, F.M., Gore, A., Mirejovsky, D, Lenaz, L   +6 more
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Design of piroxicam buccal tablets using (2-hydroxypropyl)-beta-cyclodextrin

2002
Abstract
Jug, Mario, Bećirević-Laćan, Mira
openaire   +1 more source

The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-β-cyclodextrin

Journal of Pharmaceutical and Biomedical Analysis, 2005
The effect of (2-hydroxypropyl)-beta-cyclodextrin (HP-beta-CyD) on the solubility properties and spectroscopic features of hesperetin and its 7-rhamnoglucoside, hesperidin, was qualitatively and quantitatively investigated in water, by means of UV-vis absorption and fluorescence spectroscopy. The stoichiometric ratios and stability constants describing
TOMMASINI, Silvana, CALABRO', Maria, STANCANELLI, Rosanna, DONATO, Paola Agata Eustochia, COSTA, Chiara, CATANIA, Stefania, VILLARI V, FICARRA, Paola, FICARRA, Rita   +8 more
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[Effect of temperature on drug solubility in complex formation of flubendazole and 2-hydroxypropyl-beta-cyclodextrin].

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2000
Flubendazol is a veterinary antiparasitic agent which acts toxically on both adult and larval stages of round worms. It is nearly insoluble in water and it influences not only the selection of the dosage form, but also its biological availability.
D, Vetchý, M, Rabisková, E, Sucman
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Skin permeation of small PEGylated nanoparticles aided by 2-hydroxypropyl-beta-cyclodextrin

, 2014
CONTE, CLAUDIA, COSTABILE, GABRIELLA, P. Tirino, I. d???Angelo, GRASSIA, GIANLUCA, IALENTI, ARMANDO, UNGARO, FRANCESCA, QUAGLIA, FABIANA   +7 more
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Effects of 2-hydroxypropyl-beta-cyclodextrin on the solubility of metronidazole in aqueous solution

The purpose of this present study was to explore the effects of 2-hydroxypropyl-beta-cyclodextrin (HPBCD) on the solubility and stability of metronidazole in aqueous solution. From the phase solubility study, the aqueous solubility of metronidazole increased linearly as function of HPBCD concentration.
openaire   +1 more source