Recent advances in chemistry and pharmacological aspects of 2-pyridone scaffolds
Journal of Saudi Chemical Society, 2021 Background: The chemistry and applications of 2-pyridone structures have recently attracted a lot of attention due to their uses as synthetic intermediates and their biological importance.
Mostafa M.K. Amer +4 more
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Azo-hydrazone tautomerism of aryl azo pyridone dyes [PDF]
Hemijska Industrija, 2013 In the last three or four decades disperse dyes derived from pyridones (in particular azo pyridone dyes) have gained in importance, and are widely used in various fields.
Mirković Jelena M. +3 more
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Potential role of PIM1 inhibition in the treatment of SARS-CoV-2 infection
Journal of Genetic Engineering and Biotechnology, 2023 Background SARS-CoV-2 infection involves disturbing multiple molecular pathways related to immunity and cellular functions. PIM1 is a serine/threonine-protein kinase found to be involved in the pathogenesis of several viral infections. One PIM1 substrate,
Magda M. F. Ismail +8 more
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Continuous flow synthesis of some 6- and 1,6-substituted 3-cyano-4-methyl-2-pyridones [PDF]
Journal of the Serbian Chemical Society, 2019 In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical ...
Tadić Julijana +3 more
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Heterocyclic Communications, 2022 2-Pyridone is considered as one of the most famous efficient pharmaceutical compounds. Many approaches were discovered to synthesize 2-pyridone. In this present research, chloroacetylation of benzylamine at simple conditions, EtONa/EtCOONa produced N ...
Hamed Eman O. +4 more
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A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis. [PDF]
, 2014 UnlabelledIn a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120.
Almqvist, Fredrik +12 more
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Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study [PDF]
, 2014 Syftet med studien var att undersöka vilka möjligheter matematikundervisning utomhus kan ge för elevernas utveckling och lärande. Syftet var även att undersöka hur utomhusmatematik kan användas som ett komplement till den traditionella ...
Athersuch, T +8 more
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A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo [PDF]
, 2016 Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite.
Clarke, Sarah L. +7 more
core +3 more sources
Rhodium(I)-Complexes Catalyzed 1,4-Conjugate Addition of Arylzinc Chlorides to N-Boc-4-pyridone
Molecules, 2017 Rhodium(I)-complexes catalyzed the 1,4-conjugate addition of arylzinc chlorides to N-Boc-4-pyridone in the presence of chlorotrimethylsilane (TMSCl). A combination of [RhCl(C2H4)2]2 and BINAP was determined to be the most effective catalyst to promote ...
Fenghai Guo +5 more
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Low and deficient niacin status and pellagra are endemic in postwar Angola [PDF]
, 2007 BACKGROUND: Outbreaks of pellagra were documented during the civil war in Angola, but no contemporary data on the incidence of pellagra or the prevalence of niacin deficiency were available.
Cheung, E +6 more
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