Substituent-Dictated Concise Synthesis of 4,6-DisubstitutedN-Alkyl-2-pyridones and 2-Aminopyridines
, 2005 Functionalized N-alkyl-2-pyridones and 2-aminopyridines are useful precursors for the synthesis of various heterocyclic compounds of therapeutic importance. In this paper we have delineated and illustrated a direct methodology for the synthesis of 6-aryl-
Goel, Atul +2 more
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Divergent Synthesis of Functionalized Indenopyridin-2-ones and 2-Pyridones via Benzyl Group Transfer: Two Cases of Aza-semipinacol-Type Rearrangement. [PDF]
Org Lett, 2022 Sośnicki JG +5 more
europepmc +1 more source
Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics. [PDF]
Proc Natl Acad Sci U S A, 2022 Nye TM +13 more
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Rhodium-Catalyzed C6-Selective C–H Borylation of 2‑Pyridones
, 2016 A pyridine-directed, rhodium-catalyzed C6-selective C–H borylation of 2-pyridones with bis(pinacolato)diboron (pinB–Bpin) has been developed. The reaction proceeds smoothly under relatively mild conditions, and the corresponding C6-borylated 2 ...
Wataru Miura (715942) +2 more
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A Mild and Highly Diastereoselective Preparation of N-Alkenyl-2-Pyridones via 2-Halopyridinium Salts and Aldehydes. [PDF]
J Org Chem, 2021 Shivers GN, Pigge FC.
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Synthesis and Spectral Properties of 1-(6-Methoxy-2-benzothiazolyl)-2-pyridones
, 1996 Substituted 1-(6-methoxy-2-benzothiazolyl)-2-pyridones 5a-5f have been prepared from N-(6-methoxy-2-benzothiazolyl)cyanoacetamide (2) which on reactions with 4-substituted benzaldehydes gives 3-aryl-2-cyano-N-(6-methoxy-2-benzothiazolyl)-2-propenamides ...
Jarmila Štetinová +4 more
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Streamlining the Synthesis of Pyridones through Oxidative Amination [PDF]
Herein we report the development of an oxidative amination process for the streamlined synthesis of pyridones from cyclopentenones. Cyclopentenone building blocks can undergo in situ silyl enol ether formation, followed by the introduction of a nitrogen ...
Florian, Ruepp +5 more
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A one-pot, metal-free approach to bicyclic 2-pyridones
, 2017 A practical one-pot process based on two-fold intramolecular cyclizations provides a more expedient entry into a variety of bicyclic 2-pyridones.
Wannaporn Disadee, Somsak Ruchirawat
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Microwave-Assisted Synthesis of Highly Substituted Aminomethylated 2-Pyridones
, 2016 By employing microwave-assisted organic synthesis (MAOS) efficient conditions to introduce aminomethylene substituents in highly substituted bicyclic 2-pyridones have been established.
Andreas Westermark (2702545) +4 more
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Some reactions of 2-pyridones and isoquinolinium salts [PDF]
A review of [4+ + 2] cationic polar cycloaddition reactions is presented, emphasizing mainly those reactions undergone by large heterocyclic cations. Special attention is paid to the modern mechanistic standpoint for these transformations.
Gisby, G. P.
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