Results 141 to 150 of about 24,424,699 (186)

5,5-Diphenyl-2-thiohydantoin

Acta Crystallographica Section C Crystal Structure Communications, 1998
The molecular structure of the title compound, 5,5-diphenyl-2-thioxoimidazolidin-4-one, C 15 H 12 N 2 OS, resembles that of 5,5-diphenylhydantoin (phenytoin). The C=S distance is 1.648 (2) A. The crystal structure consists of ribbon-like infinite sheets of molecules bonded by N-H...O and N-H...S hydrogen bonds.
A. W. Roszak, D. F. Weaver
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Derivatives of 2-thiohydantoin as spectrophotometric analytical reagents

Talanta, 1978
The synthesis, characteristics, properties and reaction with metallic ions of four pyridine derivatives of 2-thiohydantoin have been studied. 5-(2-Pyridyl)methylene-2-thiohydantoin, 5-(6-methyl-2-pyridyl) methylene-2-thiohydantoin, 5-(di-2-pyridyl)methylene-2-thiohydantoin and 5-[1-(2-pyridyl)-1-methyl] methylene-2-thiohydantoin have been synthesized ...
M T, González, J L, Ariza, F, Pino, R G, Villanova   +3 more
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Design, Synthesis, and Biological Activity of β-Carboline Analogues Containing Hydantoin, Thiohydantoin, and Urea Moieties

Journal of Agricultural and Food Chemistry, 2018
A series of novel β-carboline derivatives was designed by combining the anti-tobacco mosaic virus (TMV) lead compound tetrahydro-β-carboline ester with the hydantoin, thiohydantoin, and urea motifs.
Hongjian Song, Qingmin Wang, Yuxiu Liu   +2 more
exaly   +2 more sources

Condensation on Alumina. III. Synthesis of 5-Alkylidene, 2-Thiohydantoin from 3-Acetyl, 2-Thiohydantoin

Synthetic Communications, 1987
Abstract A convenient procedure for the synthesis of 5-alkylidene, 2-thiohydantoin is described.
D. Villemin, M. Ricard
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5,5-Diaryl-2-thiohydantoins and 5,5-diaryl N3-substituted 2-thiohydantoins as potential hypolipidemic agents

Journal of Medicinal Chemistry, 1986
A series of 5,5-diaryl-2-thiohydantoins and 5,5-diaryl-N3-substituted-2-thiohydantoins related to 5,5-diphenyl-2-thiohydantoin (DPTH) were investigated as potential hypolipidemic agents with the goal of increased potency over DPTH itself. In the 5,5-diaryl class, the best results were obtained by substituting two pyridyl rings for the phenyl rings ...
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Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity

European Journal of Medicinal Chemistry, 2015
DNA topoisomerase I is a potential chemotherapeutic target. Here, we designed and synthesized a library comprising of hydantoin and thiohydantoin derivatives and tested them against human and Leishmania Top1.
Chandramohan Bathula, Subhabrata Sen, Rahul Agarwal   +2 more
exaly   +2 more sources

The condensation of anthranilic acid with S-methyl-2-thiohydantoin

Experientia, 1962
Die Struktur des Kondensations-produktes aus Anthranilsaure und S-Methyl-2-thiohydantoin, bzw. aus Anthranilsauremethylester und N-Cyanglycinathylester5 wurde als die eines 2,5-(1 H, 3 H) Imidazo(2,1-b) chinazolindions bewiesen.
K, LEMPERT, G, DOLESCHALL
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IR Spectroscopic Characterization of 2‐Thiohydantoins and 2‐Thiobarbiturates

Journal of Pharmaceutical Sciences, 1976
A characterization of 2-thiohydantoins and 2-thiobarbiturates by IR spectra is proposed, using three characteristic group frequencies: the "thioureide band" around 1500 cm-1 and the antisymmetric-symmetric stretching modes of NCS bonds around 1400 and 1200 cm-1.
J, Poupaert, R, Bouche
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Inhibition of the effects of thyroxine by 5,5-diphenyl-2-thiohydantoin

Biochemical Pharmacology, 1971
Abstract 5,5-Diphenyl-2-thiohydantoin (DPTH), the sulfur analog of 5,5-diphenylhydantoin (dilantin), inhibited the induction of rat tissue mitochondrial α-glycerophosphate dehydrogenase (GPD) and the stimulation of whole-body metabolic rate by exogenous thyroxine (T 4 ). It did not affect the tissue uptake, the biliary excretion, or the enterohepatic
J V, Marx, D A, Richert, W W, Westerfeld, W R, Ruegamer   +3 more
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Synthesis of 3‐Ω‐Amino‐2‐thiohydantoins.

ChemInform, 2003
AbstractIn the reaction of ethyl isothiocyanatoacetate with diamines, followed by cyclization of the intermediate product, 3‐monosubstituted thiohydantoins have been obtained. It was found that the reaction course depends on the purity of the isothiocyanate used and also, in the case of dialkylaminoamines, the self‐cyclization occurs.
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