Mn-catalysed acceptorless dehydrogenative condensation of ureas with 1,2-diols for synthesizing imidazolones [PDF]
Communications ChemistryA plethora of biologically active compounds contain an imidazolones system as a central skeleton. Therefore, developing efficient methods for constructing such a skeleton holds significant research value.
Jiaqiao Ding +7 more
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[3+2]-Cycloaddition of azomethine ylides to 5-methylidene-3-aryl-2-сhalcogen-imidazolones: access to dispiro indolinone-pyrrolidine-imidazolones [PDF]
Royal Society Open Science, 2022 A synthesis of dispiro derivatives from 5-methylidene-2-chalcogenimidazolones and azomethine ylides generated from isatins and N-substituted α-amino acids has been developed.
Elena Beloglazkina +2 more
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Chemistry, 2023 Finding an effective anticancer drug to combat cancer cell resistance remains a challenge. Herein, we synthesized a new series of imidazolone derivatives 4a–4i and assessed their anticancer activities against liver cancer cells (Hep3B), Hela cells, and ...
Mohyeddin Assali +2 more
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Chalcogen-Varied Imidazolone Derivatives as Antibiotic Resistance Breakers in Staphylococcus aureus Strains [PDF]
Antibiotics, 2023 In this study, a search for new therapeutic agents that may improve the antibacterial activity of conventional antibiotics and help to successfully overcome methicillin-resistant Staphylococcus aureus (MRSA) infections has been conducted.
Karolina Witek +11 more
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Three-Component Reactions of 3-Arylidene-3H-Indolium Salts, Isocyanides and Amines [PDF]
Molecules, 2021 A multicomponent reaction of isocyanides with aryl(indol-3-yl)methylium salts and amines has been found. A series of aryl(indol-3-yl)acetimidamides was obtained in up to 96% yields.
Hung M. Nguyen +4 more
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Design, synthesis, anticancer properties, and molecular docking of imidazolone derivatives with lipophilic moiety [PDF]
Scientific ReportsAs part of an ongoing investigation into imidazolone derivatives with anticancer activities, herein we present the synthesis of a new series of imidazolones with various substituents, including lipophilic and hydrophilic. All synthesized imidazolones (3a–
Oswa Fares +10 more
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Dispiroindolinone–Glutarimide Conjugates: Synthesis and Evaluation as Potential Hetero-PROTACs for p53 Reactivation [PDF]
MoleculesA convergent scheme for the preparation of conjugates with the dispiroindolinone-pyrrolidine-thioimidazolone and glutarimide moieties connected via a triazole-containing linker is proposed.
Vladislav S. Polyakov +7 more
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Pharmacological investigations of newly synthesized oxazolones and imidazolones as COX-2 inhibitors [PDF]
Saudi Pharmaceutical JournalOxazoles and Imidazoles are heterocyclic compounds with significant biological activities. The present study explores the pharmacological effects of some new oxazole and imidazole derivatives as potential COX-2 inhibitors.
Iqra Saleem Naz Babari +4 more
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Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance [PDF]
Molecules, 2020 Multidrug resistance (MDR) is a severe problem in the treatment of cancer with overexpression of glycoprotein P (Pgp, ABCB1) as a reason for chemotherapy failure.
Aneta Kaczor +6 more
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Kondensierte Imidazolone / Condensed Imidazolones
Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences, 1985 11-13. The dehydrogenation of 2-tert-amino-2,2-diphenyl-acetamides with cyclic amine components gives under neighbouring the corresponding condensed imidazolones With analogous reactions of 2-tert-amino-2-phenylacetamides on dependence of the ring size of the amine cycle, a different course is observed resulting in the ...
Hans Möhrle, Hans-Jörg Hemmerling
exaly +2 more sources