Results 31 to 40 of about 524 (174)

Palladium-Catalyzed Carbonylative Cross-Coupling with Imines:  A Multicomponent Synthesis of Imidazolones

open access: yes, 2016
The palladium-catalyzed coupling of imines, chloroformates, organotin reagents, and carbon monoxide leads to the one-pot formation of ketocarbamates in good yields.
Bruce A. Arndtsen (1310721)   +2 more
core   +1 more source

Oleanolic Acid‐Enriched Olive Oil Attenuates Kidney Function Decline in Patients With Type 2 Diabetes: Results From the OLTRAD Randomised Controlled Trial

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Chronic kidney disease (CKD) is a major complication of type 2 diabetes mellitus (T2DM), driven in part by oxidative stress and the accumulation of advanced glycation end products (AGEs). Oleanolic acid (OA), a natural triterpene present in olive‐derived matrices, may modulate AGE metabolism.
Aída García‐González   +14 more
wiley   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

open access: yesThe Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos   +3 more
wiley   +1 more source

Chemo- and Regioselective 1,3-Dipolar Cycloaddition of Nitrile Imines to 5-Arylmethylene-2-methylthiohydantoins

open access: yesOrganics
1,3-Dipolar cycloaddition reactions of nitrile imines are a powerful tool for the construction of spirocyclic frameworks, yet controlling chemoselectivity remains challenging when dipolarophiles contain multiple reactive sites.
Maria E. Filkina   +4 more
doaj   +1 more source

Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid

open access: yesChemistryEurope, Volume 4, Issue 1, January 2026.
Amyloid‐selective catalytic photooxygenation reduces amyloid toxicity, aggregation tendencies, and seeding activities. Achieving therapeutic catalysis for intracellular amyloids is challenging due to conflicting oxygenation and reductive cellular environments.
Atsushi Iwai   +11 more
wiley   +1 more source

Synthèses et fonctionnalisations de noyaux imidazolones : utilisations innovantes d'isonitriles et d'oxazolines

open access: yes, 2020
Up until now, arylidene-4-imidazolones and dialkyl-(4,4’)-imidazolones derivatives are subject of longing for scientists both in the field of materials with fluorescence properties, and medical area, in particular for the treatment of diseases such as ...
Frippiat, Steven
core   +1 more source

Bioinspired Light‐Driven Organic Rotary Molecular Systems

open access: yesChemistryEurope, Volume 4, Issue 1, January 2026.
This review explores the evolution of bioinspired light‐driven rotary molecular systems (RMSs), highlighting the integration of natural chromophore‐based fragments to enhance quantum efficiency, photostability, and biocompatibility. Key strategies to optimize photochemical performance and broaden functional applications are discussed, providing a ...
Lidia Hortigüela, Sara P. Morcillo
wiley   +1 more source

Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64Cu PET/MRI

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 2, Page 268-279, January 2026.
Background and Purpose Methanobactins are peptides with high copper affinity and potential to treat Wilson disease. We examined how two methanobactins (ARBM101 and MB‐OB3b) affected copper handling in the LPP Atp7b−/− Wilson disease rat model, compared to penicillamine or saline, by 64Cu positron emission tomography/magnetic resonance imaging ...
Emilie Munk Lynderup   +11 more
wiley   +1 more source

Rational Design of 7‐Azaindole‐Based Robust Microporous Hydrogen‐Bonded Organic Framework for Gas Sorption

open access: yesAngewandte Chemie, Volume 137, Issue 1, January 2, 2025.
A preorganized tetrapodal building block, incorporating α‐carboline units, self‐assembles to form a 3D hydrogen‐bonded organic framework (HOF). The expanded hydrogen bonding between the heteroaromatic substructures, along with intermolecular π–π interactions, spontaneously build up an interpenetrated architecture that bestows an extraordinary ...
Manuel Carrera   +10 more
wiley   +2 more sources

Fingertip skin autofluorescence as a non‐invasive marker for vascular complications in patients with type 2 diabetes

open access: yesJournal of Diabetes Investigation, Volume 16, Issue 12, Page 2201-2212, December 2025.
This multicenter study demonstrated that fingertip autofluorescence, measured non‐invasively, correlates with clinical risk factors and vascular complications in patients with type 2 diabetes. Our findings suggest that fingertip autofluorescence may serve as a convenient marker for evaluating both microvascular and macrovascular complications in ...
Minoru Takeshita   +16 more
wiley   +1 more source

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