Results 1 to 10 of about 1,538 (160)

Design, synthesis, anticancer properties, and molecular docking of imidazolone derivatives with lipophilic moiety [PDF]

Scientific Reports
As part of an ongoing investigation into imidazolone derivatives with anticancer activities, herein we present the synthesis of a new series of imidazolones with various substituents, including lipophilic and hydrophilic. All synthesized imidazolones (3a–
Othman Hamed
exaly   +3 more sources

Fluorescence Lifetime Multiplexing with Fluorogen-Activating FAST Protein Variants and Red-Shifted Arylidene–Imidazolone Derivative as Fluorogen [PDF]

Biosensors
Fluorescence-lifetime imaging microscopy (FLIM) is a powerful technique for highly multiplexed imaging in live cells. In this work, we present a genetically encoded FLIM multiplexing platform based on a combination of fluorogen-activating protein FAST ...
Aidar Gilvanov, Eugene Maksimov, Vadim Kublitski   +2 more
exaly   +4 more sources

Design, Synthesis, and Structure-Activity Relationships of Novel Piperidine-Fused Imidazolone ClpP Activators as Potential Anti-Cancer Agents [PDF]

Molecules
Caseinolytic protease P (ClpP) is essential for maintaining mitochondrial protein homeostasis, and its activation has emerged as an attractive cancer therapeutic strategy. However, ONC201 is currently the only approved ClpP activator, and its low potency
Shanshan Chen, Xinyi Lin, Min Guo, Ruqi Lei, Beijing Chen, Yubo Zhou, Aijun Qiao, Qi Huang, Mingliang Wang   +8 more
doaj   +2 more sources

Design, Synthesis and in Vivo Anti-inflammatory Activities of 2,4-Diaryl-5-4H-imidazolone Derivatives

Molecules, 2012
A series of 2,4-diaryl-5(4H)-imidazolones were prepared and evaluated for their anti-inflammatory activities. Some selected 2,4-diaryl-5(4H)-imidazolones exhibited excellent anti-inflammatory activity in the carrageenan-induced rat paw edema model ...
Abdelsattar Omar
exaly   +3 more sources

Synthesis, crystal structure and Hirshfeld surface analysis of 5,5-diphenyl-2-[2-(propan-2-ylidene)hydrazin-1-yl]-4,5-dihydro-1H-imidazol-4-one N,N-dimethylformamide hemisolvate [PDF]

Acta Crystallographica Section E: Crystallographic Communications
The asymmetric unit of the title structure, 2C18H18N4O2·C3H7NO, consists of two independent molecules of the substituted imidazolone having different conformations, and one molecule of solvent DMF.
Abderrazzak El Moutaouakil Ala Allah, Benson M. Kariuki, Walid Guerrab, Abdulsalam Alsubari, Musa A. Said, Joel T. Mague, Youssef Ramli   +6 more
doaj   +2 more sources

Chalcogen-Varied Imidazolone Derivatives as Antibiotic Resistance Breakers in Staphylococcus aureus Strains [PDF]

Antibiotics, 2023
In this study, a search for new therapeutic agents that may improve the antibacterial activity of conventional antibiotics and help to successfully overcome methicillin-resistant Staphylococcus aureus (MRSA) infections has been conducted.
Karolina Witek, Aneta Kaczor, Ewa Żesławska, Sabina Podlewska, Małgorzata Anna Marć, Kinga Czarnota-Łydka, Wojciech Nitek, Gniewomir Latacz, Waldemar Tejchman, Markus Bischoff, Claus Jacob, Jadwiga Handzlik   +11 more
doaj   +2 more sources

1-Ethenyl-2-(methylsulfanyl)-4,4-diphenyl-4,5-dihydro-1H-imidazol-5-one (Thiophenytoin analogue): synthesis, structure and Hirshfeld surface analysis [PDF]

Acta Crystallographica Section E: Crystallographic Communications
The title molecule, C18H16N2OS, exhibits a slight ‘ruffling' of the imidazolone ring, and the lone pair on the tricoordinate nitrogen atom is involved in N→C π-bonding within the ring.
Abderrazzak El Moutaouakil Ala Allah, Chiara Massera, Joel T. Mague, Abdulsalam Alsubari, Youssef Ramli   +4 more
doaj   +2 more sources

Mn-catalysed acceptorless dehydrogenative condensation of ureas with 1,2-diols for synthesizing imidazolones [PDF]

Communications Chemistry
A plethora of biologically active compounds contain an imidazolones system as a central skeleton. Therefore, developing efficient methods for constructing such a skeleton holds significant research value.
Jiaqiao Ding, Di Kang, Tianshu Kou, Shan Lv, Siyi Song, Bing Cui, Mingqin Zhao, Zhihui Shao   +7 more
doaj   +2 more sources

Exploring insecticidal activity and SAR study of newly synthesized Benzo[h]quinoline-based heterocycles against Aphis craccivora Koch. and Culex pipiens L. Larvae [PDF]

Scientific Reports
The key material, 2-chlorobenzo[h]quinoline-3-carbaldehyde condensed with various active-methylene reagents to produce some benzo[h]quinoline-based heterocycles like pyrazolone, imidazolone, thiazolidine, pyrimidinone, and indolinone candidates.
Eman A. E. El-Helw, Doaa R. Abdel-Haleem, Ali Kh. Khalil, Sayed K. Ramadan   +3 more
doaj   +2 more sources

Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain [PDF]

Nature Communications
Selective perturbation of protein interactions with chemical compounds enables dissection and control of developmental processes. Differentiation of stomata, cellular valves vital for plant growth and survival, is specified by the basic-helix-loop-helix (
Ayami Nakagawa, Krishna Mohan Sepuru, Shu Jan Yip, Hyemin Seo, Calvin M. Coffin, Kota Hashimoto, Zixuan Li, Yasutomo Segawa, Rie Iwasaki, Hiroe Kato, Daisuke Kurihara, Yusuke Aihara, Stephanie Kim, Toshinori Kinoshita, Kenichiro Itami, Soon-Ki Han, Kei Murakami, Keiko U. Torii   +17 more
doaj   +2 more sources