Skeletal health in adolescents with poorly controlled type 1 diabetes: results from a randomized controlled trial [PDF]
BMJ Open Diabetes Research & CareIntroduction Poorly controlled type 1 diabetes (T1D) has been associated with impaired bone health, but the mechanisms remain unclear. We aimed to investigate whether changes in glycemic control and glucose variability are associated with skeletal health
Mari-Anne Pulkkinen +6 more
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Computational elucidation of stomidazolone mediated inhibition of stomatal differentiation and its implication in plant developmental regulation. [PDF]
PLoS ONEStomata play a critical role in plant physiology by balancing gas exchange and water conservation. Their development is driven by a precisely orchestrated sequence of cell divisions and differentiation events, regulated by basic helix-loop-helix (bHLH ...
Syeda Sumayya Tariq +7 more
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The Influence of Clustered DNA Damage Containing Iz/Oz and OXOdG on the Charge Transfer through the Double Helix: A Theoretical Study [PDF]
MoleculesThe genome—the source of life and platform of evolution—is continuously exposed to harmful factors, both extra- and intra-cellular. Their activity causes different types of DNA damage, with approximately 80 different types of lesions having been ...
Bolesław T. Karwowski
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The State of Imidazolone as an Evolving Pharmacophore: Current Progress and Clinical Significance in Oncology and AMR [PDF]
ACS OmegaPreetesh Kumar Panda +4 more
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Frontiers in Pharmacology, 2022 Structural changes of small-molecule drugs may bring interesting biological properties, especially in the field of kinase inhibitors. We sought to study tirbanibulin, a first-in-class dual Src kinase (non-ATP competitive)/tubulin inhibitor because there ...
Maan T. Khayat +14 more
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Preparation of new substituted imidazolone derivatives based on 1-(2-oxo-2-phenylethylidene)pyrrolo[3,2,1-ij]quinolin-2-ones [PDF]
Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2023 This work demonstrates the possibility of obtaining new biologically active molecules containing a privileged imidazolone fragment by the Brønsted acid-catalyzed reaction of 1,3-dimethylurea with 1-(2-oxo-2-phenylethylidene)pyrrolo[3,2,1-ij ...
Skoptsova, Anna Aleksandrovna +3 more
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Molecules, 2022 A group of novel trimethoxyphenyl (TMP)-based analogues were synthesized by varying the azalactone ring of 2-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxybenzylidene)oxazolone 1 and characterized using NMR spectral data as well as elemental microanalyses ...
Tarfah Al-Warhi +10 more
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A novel application of Co3O4@SiO2 nanocomposite as an efficient and robust catalyst for the preparation of some imidazolone derivatives [PDF]
Journal of Particle Science and Technology, 2018 In the present work, a simple, green and efficient procedure for the synthesis of imidazolone derivatives is described via the reaction of oxazolones and different arylamines in the presence of Co3O4@SiO2 nanocomposite as a catalyst under solvent-free ...
Taleb Asadi +2 more
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Mapping glycation and glycoxidation sites in collagen I of human cortical bone
BBA Advances, 2023 Accumulation of advanced glycation end products (AGEs), particularly in long-lived extracellular matrix proteins, has been implicated in pathogenesis of diabetic complications and in aging.
Paul Voziyan +4 more
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DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF ANTIBACTERIAL AND ANTIADHESIVE POTENTIALS OF SOME SUBSTITUTED IMIDAZOLONES DERIVATIVES OF CINNAMALDEHYDE [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2016 The cells of microorganisms often stick together and adhere to biotic and inert surfaces to form coats (biofilms) that are impenetrable and often highly resistant to antibiotics, as well as beingadaptive to immune responses of the host.
Abdelsattar Omar
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