Results 1 to 10 of about 5,630 (210)

Contact hypersensitivity to oxazolone provokes vulvar mechanical hyperalgesia in mice. [PDF]

PLoS ONE, 2013
The interplay among pain, allergy and dysregulated inflammation promises to yield significant conceptual advances in immunology and chronic pain. Hapten-mediated contact hypersensitivity reactions are used to model skin allergies in rodents but have not ...
Tijana Martinov, Rose Glenn-Finer, Sarah Burley, Elena Tonc, Evelyn Balsells, Alyssa Ashbaugh, Linnea Swanson, Randy S Daughters, Devavani Chatterjea   +8 more
doaj   +3 more sources

Functional characterization of oxazolone-induced colitis and survival improvement by vagus nerve stimulation. [PDF]

PLoS ONE, 2018
BACKGROUND:Oxazolone-induced colitis has been frequently used in literature as a model of IBD, but insights into the underlying immune response and pathological features are surprisingly still very limited.
Elisa Meroni, Nathalie Stakenborg, Pedro J Gomez-Pinilla, Gert De Hertogh, Gera Goverse, Gianluca Matteoli, Simon Verheijden, Guy E Boeckxstaens   +7 more
doaj   +2 more sources

Cardamonin Inhibits Oxazolone-Induced Atopic Dermatitis by the Induction of NRF2 and the Inhibition of Th2 Cytokine Production

Antioxidants, 2020
The skin is constantly exposed to various types of chemical stresses that challenge the immune cells, leading to the activation of T cell-mediated hypersensitivity reactions including atopic dermatitis.
Won Jun Choi, Young-Sam Keum
exaly   +3 more sources

Protective Effects of Topical Administration of Laminarin in Oxazolone-Induced Atopic Dermatitis-like Skin Lesions

Marine Drugs, 2022
Laminarin is a polysaccharide isolated from brown marine algae and has a wide range of bioactivities, including immunoregulatory and anti-inflammatory properties. However, the effects of laminarin on atopic dermatitis have not been demonstrated.
Choong-Hyun Lee, Dae Won Kim, Moo Ho Won   +2 more
exaly   +3 more sources

Anti-inflammatory efficacy of diosgenin in an oxazolone-induced model of ulcerative colitis in mice via suppression of Th2 pathways and pSTAT3 expression: A prospective study [PDF]

Science Progress
Objective This prospective study evaluated the therapeutic efficacy of Diosgenin in mitigating Oxazolone-induced ulcerative colitis in male BALB/c mice.
Ashwini Narayan, Priya Babu Shubha, Syed Baker, Niranjan Raj Sathyanarayana, Faiyaz Ahmed, Nanjunda Swamy Shivananju   +5 more
doaj   +2 more sources

Changes in expression of NLRP3 inflamasome and IL-1β in the development of oxazolone-induced colitis in rats and on the background of administration of simvastatin and interleukin-1β receptor antagonist

Patologìâ, 2021
The aim. To study the expression of mRNA of the NLRP3 inflammasome and proinflammatory cytokine IL-1β in the inflamed colon of rats with experimental oxazolone-induced colitis and against the background of the introduction of simvastatin and antagonist ...
O. S. Zherebiatiev, N. M. Polishchuk
doaj   +1 more source

Synthesis and Biological Activity Screening of Newly Synthesized Trimethoxyphenyl-Based Analogues as Potential Anticancer Agents

Molecules, 2022
A group of novel trimethoxyphenyl (TMP)-based analogues were synthesized by varying the azalactone ring of 2-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxybenzylidene)oxazolone 1 and characterized using NMR spectral data as well as elemental microanalyses ...
Tarfah Al-Warhi, Matokah Abualnaja, Ola A. Abu Ali, Fayez Althobaiti, Fahad Alharthi, Fahmy G. Elsaid, Ali A. Shati, Eman Fayad, Doaa Elghareeb, Ali H. Abu Almaaty, Islam Zaki   +10 more
doaj   +1 more source

Synthesis, Antibacterial and Antioxidant Evaluation of 2-Substituted-4-arylidene-5(4H)-oxazolone Derivatives

Indonesian Journal of Chemistry, 2023
In this research, the synthesis of new substituted oxazolone derivatives is described via Erlenmeyer synthesis of N-acyl amino acid. Firstly, the azo derivative 1 was prepared by coupling the diazonium salt of 3-amino-4-methoxybenzoic acid with 4,5 ...
Lina Saadi, Shaimaa Adnan
doaj   +1 more source

A novel application of Co3O4@SiO2 nanocomposite as an efficient and robust catalyst for the preparation of some imidazolone derivatives [PDF]

Journal of Particle Science and Technology, 2018
In the present work, a simple, green and efficient procedure for the synthesis of imidazolone derivatives is described via the reaction of oxazolones and different arylamines in the presence of Co3O4@SiO2 nanocomposite as a catalyst under solvent-free ...
Taleb Asadi, Mohammad Ali Ghasemzadeh, Manoochehr Fadaeian   +2 more
doaj   +1 more source

Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation

iScience, 2020
Summary: Inflammatory response heterogeneity has impeded high-resolution dissection of diverse immune cell populations during activation. We characterize mouse cutaneous immune cells by single-cell RNA sequencing, after inducing inflammation using ...
Yale Liu, Christopher Cook, Andrew J. Sedgewick, Shuyi Zhang, Marlys S. Fassett, Roberto R. Ricardo-Gonzalez, Paymann Harirchian, Sakeen W. Kashem, Sho Hanakawa, Jacob R. Leistico, Jeffrey P. North, Mark A. Taylor, Wei Zhang, Mao-Qiang Man, Alexandra Charruyer, Nadejda Beliakova-Bethell, Stephen C. Benz, Ruby Ghadially, Theodora M. Mauro, Daniel H. Kaplan, Kenji Kabashima, Jaehyuk Choi, Jun S. Song, Raymond J. Cho, Jeffrey B. Cheng   +24 more
doaj   +1 more source