Results 11 to 20 of about 5,630 (210)
Journal of Pharmacological Sciences, 2010 We investigated pharmacological characteristics of the itch-associated response to chronic dermatitis induced by 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone) repeated application in mice.
Yukihito Tsukumo +2 more
doaj +2 more sources
Journal of Pharmacological Sciences, 2011 We investigated the effects of gabapentin and pregabalin on the itch-associated response in a mouse model of chronic dermatitis induced by the repeated application of 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone).
Yukihito Tsukumo +4 more
doaj +2 more sources
CCL25/CCR9 interactions regulate the function of iNKT cells in oxazolone-induced colitis in mice. [PDF]
PLoS ONE, 2014 Natural killer T (NKT) cells share phenotypic and functional properties with both conventional natural killer cells and T cells. These cells might have an important role in the pathogenesis of ulcerative colitis (UC).
Siying Zhu +10 more
doaj +2 more sources
Selective impairment of T lymphocyte activation following contact sensitization with oxazolone
, 1991 We have previously reported that topical exposure of mice to oxazolone results in the appearance of regulatory mechanisms which markedly depress lymph node cell (LNC) proliferative responses to subsequent challenge with the same chemical.
Baker, D. +3 more
core +10 more sources
Mesenteric Adipose Tissue as a Modulator of Intestinal Inflammation: Mechanistic Insights and Model Systems in Crohn's Disease. [PDF]
Eur J ImmunolThis review explores how mesenteric adipose tissue, particularly creeping fat, contributes to intestinal inflammation through dysregulated adipokine signalling. We explore how metabolic stress alters immune‐adipose interactions and promotes disease progression.
Omar T, Weidinger C, Siegmund B.
europepmc +2 more sources
Contribution of One-Electron Oxidation of Purine and Pyrimidine Bases to the Photo- and Radiation-Induced Damage to Cellular DNA. [PDF]
ChemphyschemOne‐electron oxidation of purine and pyrimidine bases of isolated and cellular DNA generates related reactive base radical cations that are converted into final decomposition products through deprotonation and hydration. In the case of guanine, the most susceptible nucleobase to one‐electron oxidants, 8‐hydroxy‐7,8‐dihydroguanyl radical, thus formed by
Cadet J +3 more
europepmc +2 more sources
Chemistry, 2023 Finding an effective anticancer drug to combat cancer cell resistance remains a challenge. Herein, we synthesized a new series of imidazolone derivatives 4a–4i and assessed their anticancer activities against liver cancer cells (Hep3B), Hela cells, and ...
Saber Abu-Jabal +10 more
doaj +1 more source
SYNTHESIS AND ANTICANCER ACTIVITY OF IMIDAZOLE DERIVATIVES INCORPORATING CHROMENE MOIETY [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2012 The oxo-chromene-6-carbaldehyde derivative 1 was used as a starting material for the synthesis of some novel pyrano[3,2-b] xanthene-4,7-dione 2 and chromen-oxazol-5-(4H)-one derivatives 4,5.
Nashwa Saleh
doaj +1 more source
Molecules, 2022 Electron-rich, nitrogenous heteroaromatic compounds interact more with biological/cellular components than their non-nitrogenous counterparts. The strong intermolecular interactions with proteins, enzymes, and receptors confer significant biological and ...
Rasha Saad Suliman +10 more
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Shedding Light on the Chemistry and the Properties of Münchnone Functionalized Graphene
Nanomaterials, 2021 Münchnones are mesoionic oxazolium 5-oxides with azomethine ylide characteristics that provide pyrrole derivatives by a 1,3-dipolar cycloaddition (1,3-DC) reaction with acetylenic dipolarophiles. Their reactivity was widely exploited for the synthesis of
Giulia Neri +6 more
doaj +1 more source