Results 31 to 40 of about 5,630 (210)

Characterization and Chemical Stability of Photooxidized Oligonucleotides that Contain 2,2-Diamino-4-[(2-deoxy-β-d-erythro-pentofuranosyl)amino]-5(2H)-oxazolone

, 2016
The chemical insertion of 2,2-diamino-4-[(2-deoxy-β-d-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), a major oxidation compound of 2‘-deoxyguanosine, into oligonucleotides is a challenging issue, due to the high alkali lability of the lesion.
Jean Cadet (14780), Didier Gasparutto (6669), Jean-Luc Ravanat (542307), Olivier Gérot (3004260)   +3 more
core   +1 more source

Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation [PDF]

, 2015
ES-62 is the major secreted protein of the rodent filarial nematode Acanthocheilonema viteae. The molecule contains covalently attached phosphorylcholine (PC) residues, which confer anti-inflammatory properties on ES-62, underpinning the idea that drugs ...
Al-Riyami, Lamyaa, Harnett, Margaret M., Rzepecka, Justyna, Suckling, Colin J., Pineda, Miguel A., Rodgers, David T., Harnett, William   +6 more
core   +5 more sources

Comprehensive Phytochemical Profiling of Polyherbal Divya-Kayakalp-Vati and Divya-Kayakalp-Oil and Their Combined Efficacy in Mouse Model of Atopic Dermatitis-Like Inflammation Through Regulation of Cytokines

Clinical, Cosmetic and Investigational Dermatology, 2022
Acharya Balkrishna,1,2 Sudeep Verma,1 Sachin Sakat,1 Kheemraj Joshi,1 Siva K Solleti,1 Kunal Bhattacharya,1 Anurag Varshney1,2 1Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, 249 405, Uttarakhand, India; 2Department of ...
Balkrishna A, Verma S, Sakat S, Joshi K, Solleti SK, Bhattacharya K, Varshney A   +6 more
doaj  

Design, Synthesis and in Vivo Anti-inflammatory Activities of 2,4-Diaryl-5-4H-imidazolone Derivatives

Molecules, 2012
A series of 2,4-diaryl-5(4H)-imidazolones were prepared and evaluated for their anti-inflammatory activities. Some selected 2,4-diaryl-5(4H)-imidazolones exhibited excellent anti-inflammatory activity in the carrageenan-induced rat paw edema model ...
Abdel-Ghany H. El-Helby, Asharf A. Abdel-Rahman, Hassanein H. Hassanein, Moustafa El-Araby, Abdelsattar Omar   +4 more
doaj   +1 more source

Characterization of oxazolone-induced colitis model.

, 2018
(A) Wild type BALB/c mice were sensitized by epicutaneous application of 3% oxazolone at a dilution of 4:1 in a mixture of acetone and olive oil (100μl) on day 0, followed by intracolonic administration of 1% oxazolone dissolved in 50% ethanol (100μl ...
Pedro J. Gomez-Pinilla (478993), Elisa Meroni (5264507), Guy E. Boeckxstaens (421150), Gert De Hertogh (256864), Simon Verheijden (5264513), Gianluca Matteoli (259596), Nathalie Stakenborg (508024), Gera Goverse (5264510)   +7 more
core   +1 more source

Exogenous murine antimicrobial peptide CRAMP significantly exacerbates Ovalbumin-induced airway inflammation but ameliorates oxazolone-induced intestinal colitis in BALB/c mice

Human Vaccines & Immunotherapeutics, 2018
Cathelicidin has been reported to be multifunctional. The current study aimed to investigate the influences of exogenous cathelicidin-related antimicrobial peptide (CRAMP) on inflammatory responses in different disease models.
Yang Li, Xiaojie Chu, Cunbao Liu, Weiwei Huang, Yufeng Yao, Ye Xia, Pengyan Sun, Qiong Long, Xuejun Feng, Kui Li, Xu Yang, Hongmei Bai, Wenjia Sun, Yanbing Ma   +13 more
doaj   +1 more source

Different Patterns of Pd-Promoted C-H Bond Activation in (Z)-4-Hetarylidene-5(4H)-oxazolones and Consequences in Photophysical Properties

Inorganics
This work aims to amplify the fluorescence of (Z)-4-hetarylidene-5(4H)-oxazolones 1 by suppression of the hula-twist non-radiative deactivation pathway by C^N-orthopalladation of the 4-hetarylidene ring.
Miguel Martínez, David Dalmau, Olga Crespo, Pilar García-Orduña, Fernando Lahoz, Antonio Martín, Esteban P. Urriolabeitia   +6 more
doaj   +1 more source

Fluorescent Orthopalladated Complexes of 4-Aryliden-5(4H)-oxazolones from the Kaede Protein: Synthesis and Characterization

Molecules, 2021
The goal of the work reported here was to amplify the fluorescent properties of 4-aryliden-5(4H)-oxazolones by suppression of the hula-twist non-radiative deactivation pathway. This aim was achieved by simultaneous bonding of a Pd center to the N atom of
Eduardo Laga, David Dalmau, Sofía Arregui, Olga Crespo, Ana I. Jimenez, Alexandra Pop, Cristian Silvestru, Esteban P. Urriolabeitia   +7 more
doaj   +1 more source

Modular and Stereoselective Synthesis of Cyclobutane β‐Amino Alcohols

Angewandte Chemie International Edition, EarlyView.
Late‐stage functionalization and photoisomerization of 1,2‐azaborine leads to a general strategy for the synthesis of diversely substituted cyclobutane β‐amino alcohols. The relative stereochemistry of the resulting products is unambiguously defined by the stereospecific and stereoselective nature of the photoisomerization‐hydrogenation‐oxidation ...
Xinyu Yang, Tomoya Ozaki, Bo Li, Shih‐Yuan Liu   +3 more
wiley   +1 more source

Clinical and Morphological Analysis of Efficacy of Intraperitoneal Ozone Application in Experimental Colitis: Preclinical Randomized Experimental Study

Кубанский научный медицинский вестник, 2023
Background. Inflammatory bowel diseases — Crohn’s disease and ulcerative colitis — are chronic gastrointestinal diseases affecting young people of working age.
M. V. Osikov, N. V. Kaygorodtceva, M. S. Boyko, L. V. Astachova   +3 more
doaj   +1 more source