Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
Synthesis of Oxazolone and Imidazolone Derivatives in Presence of H2O2 Promoted Fly Ash as a Novel and Efficient Catalyst [PDF]
A new catalyst was prepared by promoting fly ash with hydrogen peroxide. The catalytic activity of H2O2 promoted fly ash (HPFA) was evaluated by synthesis 5(4H)-oxazolone and imidazolone derivatives under solvent free conditions.
S. Fozooni +3 more
doaj
2-Phenyl-4-(3,4,5-trimethoxybenzylidene)-1,3-oxazol-5(4H)-one
The title compound, C19H17NO5, was synthesized as part of a continuing project involving the structures of oxazolone derivatives. The molecule adopts a Z configuration about the central olefinic bond.
Yi-Ping Cui, Yi-Feng Sun
doaj +1 more source
CD8+ T cell migration to the skin requires CD4+ help in a murine model of contact hypersensitivity. [PDF]
The relative roles of CD4+ and CD8+ T cells in contact hypersensitivity responses have not been fully solved, and remain an important question. Using an adoptive transfer model, we investigated the role of the respective T cell subset.
Nanna Fyhrquist +3 more
doaj +1 more source
The Relationship Between (Endo)cannabinoids, the Microbiome and Melanoma
CB1 and CB2 receptors are widely distributed in both normal and cancerous cells. Cannabinoids have a positive impact on reducing tumor growth in mice. A positive relationship exists between CB2 receptors and survival in skin melanoma. However, there is a negative impact on non‐small cell lung cancer and colon cancer, whereas a higher association of CB1
Farideh A. Javid +3 more
wiley +1 more source
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber +8 more
wiley +1 more source
Spectroscopic Evidence for an Oxazolone Structure in Anionic -Type Peptide Fragments [PDF]
Infrared spectra of anionic b-type fragments generated by collision induced dissociation (CID) from deprotonated peptides are reported. Spectra of the b2 fragments of deprotonated AlaAlaAla and AlaTyrAla have been recorded over the 800-1800 cm-1 spectral
Josipa Grzetic +3 more
core +2 more sources
Excited state aromatization assisted push-pull abilities of two unsaturated oxazolone derivatives
Molecular structures of two unsaturated oxazolone derivatives involving furan rings, which are decorated with p-tolyl (FurM) and 4-nitro phenyl (FurN), were investigated by X-ray crystallography and quantum chemical calculations. Their ground and excited
Hasan Karabıyık +2 more
doaj +1 more source
Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming
Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska +2 more
wiley +1 more source
Evidence of diketopiperazine and oxazolone structures for HA b2+ ion.
International audiencePeptide fragmentation can lead to an oxazolone or diketopiperazine b(2)(+) ion structure. IRMPD spectroscopy combined with computational modeling and gas-phase H/D exchange was used to study the structure of the b(2)(+) ion from ...
Somogyi, Arpád +5 more
core +1 more source

