Results 31 to 40 of about 1,538 (160)

Synthesis of Oxazolone and Imidazolone Derivatives in Presence of H2O2 Promoted Fly Ash as a Novel and Efficient Catalyst [PDF]

Journal of Sciences, Islamic Republic of Iran, 2017
A new catalyst was prepared by promoting fly ash with hydrogen peroxide. The catalytic activity of H2O2 promoted fly ash (HPFA) was evaluated by synthesis 5(4H)-oxazolone and imidazolone derivatives under solvent free conditions.
S. Fozooni, H. Khoshdast, H. Hassani, H. Hamidian   +3 more
doaj  

Biocatalytic Alkylation of Ambident Nucleophiles Enables Selective N‐Functionalization of Heterocycles and Late‐Stage Modifications

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
N‐alkylated heteroarenes are key structural motifs in bioactive compounds, but their regioselective synthesis via coupling of readily available azoles with haloalkanes remains very challenging. Here, we present a mild biocatalytic approach that proceeds on gram‐scale, is highly chemo‐ and regioselective, offering rapid access to valuable N‐alkylated ...
Felipe Ospina, Kai H. Schülke, Marius Schnutenhaus, Alina Klein, Om Desai, Shubhanshu Jain, Christine Krofta, Lukas Stratmann, Jianing Yang, Harald Gröger, Stephan C. Hammer   +10 more
wiley   +2 more sources

Reactions of 3′,5′-di-O-acetyl-2′-deoxyguansoine and 3′,5′-di-O-acetyl-2′-deoxyadenosine to UV light in the presence of uric acid

Genes and Environment, 2022
Introduction Recently, it was revealed that uric acid is a photosensitizer of reactions of nucleosides on irradiation with UV light at wavelengths longer than 300 nm, and two products generated from 2′-deoxycytidine were identified. In the present study,
Toshinori Suzuki, Miyu Takeuchi, Atsuko Ozawa-Tamura   +2 more
doaj   +1 more source

The synthesis of imidazo[4',5':5,6]cycloocta[1,2-B]quinoxaline-2-ones and a – thione

Bulletin of the Chemical Society of Ethiopia, 2013
At present study, we synthesized the imidazo[4',5':5,6]cycloocta[1,2-b]quinoxaline-2-ones (-2-thione) with an additional double bond in the eight-membered ring via the reaction of a quinoxaline-fused cyclooctane-1,2-dione with urea (or thiourea) and N,N'-
M.H. Alamdari
doaj   +1 more source

Oleanolic Acid‐Enriched Olive Oil Attenuates Kidney Function Decline in Patients With Type 2 Diabetes: Results From the OLTRAD Randomised Controlled Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Chronic kidney disease (CKD) is a major complication of type 2 diabetes mellitus (T2DM), driven in part by oxidative stress and the accumulation of advanced glycation end products (AGEs). Oleanolic acid (OA), a natural triterpene present in olive‐derived matrices, may modulate AGE metabolism.
Aída García‐González, Alejandro Matamoros‐Domínguez, Juan Manuel Espinosa‐Cabello, Gisela Pérez‐Muñoz, Manuel Jesús León Aranda, María Del Carmen Roque‐Cuellar, Silvia García‐Rey, Andrés Jiménez‐Sánchez, Antonio Jesús Martínez‐Ortega, Miguel Ángel Mangas‐Cruz, Isabel Cerrillo, Javier S. Perona, Pedro Pablo García‐Luna, Elena María Yubero‐Serrano, José María Castellano   +14 more
wiley   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells. [PDF]

PLoS ONE, 2018
Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels.
Kayla Thompson, Jonathan Chen, Qianyi Luo, Yucheng Xiao, Theodore R Cummins, Ashay D Bhatwadekar   +5 more
doaj   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Molecular Mimics of Classic P-Glycoprotein Inhibitors as Multidrug Resistance Suppressors and Their Synergistic Effect on Paclitaxel. [PDF]

PLoS ONE, 2017
P-glycoprotein (Pgp) is a membrane bound efflux pump spread in a variety of tumor cells and considered as a main component of multidrug resistance (MDR) to chemotherapies.
Moustafa E El-Araby, Abdelsattar M Omar, Maan T Khayat, Hanan A Assiri, Ahmed M Al-Abd   +4 more
doaj   +1 more source

Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid

ChemistryEurope, Volume 4, Issue 1, January 2026.
Amyloid‐selective catalytic photooxygenation reduces amyloid toxicity, aggregation tendencies, and seeding activities. Achieving therapeutic catalysis for intracellular amyloids is challenging due to conflicting oxygenation and reductive cellular environments.
Atsushi Iwai, Youhi Hwang, Hiroki Umeda, Taka Sawazaki, Ikumi Tomizawa, Maiko Ono, Makoto Higuchi, Youhei Sohma, Yukiko Hori, Taisuke Tomita, Harunobu Mitsunuma, Motomu Kanai   +11 more
wiley   +1 more source