Results 51 to 60 of about 1,538 (160)

In silico evaluation of cis-dihydroxy-indeno[1,2-d]imidazolones as inhibitors of glycogen synthase kinase-3: synthesis, molecular docking, physicochemical data, ADMET,MD simulation, and DFT calculations

Journal of Saudi Chemical Society
A new series of cis-dihydroxy-indeno[1,2-d]imidazolone compounds with distinct structures were synthesized to investigate their potential as inhibitors of the Glycogen synthase kinase 3 (GSK-3).
Nahid Mahmoodi, Mohammad Bayat, Davood Gheidari, Zahra Sadeghian   +3 more
doaj   +1 more source

Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Being the primary sulfonamide among the most efficient zinc binding group (ZBG) to design inhibitors for the metallo-enzymes carbonic anhydrases (CA, EC 4.2.1.1), herein, we propose an investigation on four physiologically important human (h) CAs (hCA I,
Fadi M. Awadallah, Silvia Bua, Walaa R. Mahmoud, Hossam H. Nada, Alessio Nocentini, Claudiu T. Supuran   +5 more
doaj   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Activation of Small Molecules by Readily Accessible Alkylborane‐Based Frustrated Lewis Pairs

European Journal of Inorganic Chemistry, Volume 28, Issue 15, May 28, 2025.
Simple alkylborane‐based frustrated Lewis pairs (FLPs) are demonstrated to activate hydrogen, ammonia, the NH bond of secondary amines, and the CH bonds of terminal alkynes, highlighting the potential of readily accessible FLPs for small‐molecule activation.
Arthur Averdunk, Felix Wech, Jonathan Becker, Urs Gellrich   +3 more
wiley   +1 more source

Catalyst-free, one-pot four-component synthesis of aryl-linked hydroxy-naphthoquinone fused with imidazolone and 2-hydroxy-1,4-naphthoquinone moiety: naphtho[1,2-d]imidazolyl(aryl)methylnaphthalene-1,4-diones

Results in Chemistry
Herein, we report a one-pot four-component reaction of two mol of 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes and guanidine in DMF medium at 80 °C for the easy access of aryl-linked hydroxy-naphthoquinone fused with imidazolone and 2-hydroxy-1,4 ...
Mohaddeseh Ahmadusefi-Sarhadi, Hossein Mehrabi, Farzaneh Alizadeh-Bami   +2 more
doaj   +1 more source

Engineered Living Energy Materials

Interdisciplinary Materials, Volume 4, Issue 3, Page 412-455, May 2025.
Engineered living energy materials (ELEMs) are nascent research frontier for enabling sustainable energy conversion and storage. These materials exhibit unique characteristics such as self‐regeneration, biodegradability, environmental response, and evolutionary adaptability. This paper overviews different energy conversion bio‐modules, summarizes their
Xinyi Yuan, Haiyi Xu, Xingwu Liu, Jicong Zhang, Jing Li, Qianyi Liang, Bolin An, Giuseppe Maria Paternò, Minyue Zhang, Yuqing Tang, Chen Zhang, Dake Xu, Chao Zhong, Ke Li, Xinyu Wang   +14 more
wiley   +1 more source

Insights from the fructose‐derived product glucoselysine: Revisiting the polyol pathway in diabetic complications

Journal of Diabetes Investigation, Volume 16, Issue 4, Page 569-577, April 2025.
This review focuses on the enhanced polyol pathway and the formation of glucoselysine and discusses its biochemical characteristics and clinical significance. ABSTRACT Advanced glycation end‐products (AGEs) have been extensively studied because of their close association with the onset and progression of diabetic complications.
Hiroko Yamaguchi, Ryoji Nagai
wiley   +1 more source

High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report

Journal of Diabetes Research, 2017
Objective. Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic ...
Tsuyoshi Okura, Etsuko Ueta, Risa Nakamura, Yohei Fujioka, Keisuke Sumi, Kazuhisa Matsumoto, Kyoko Shoji, Kazuhiko Matsuzawa, Shoichiro Izawa, Yuri Nomi, Hitomi Mihara, Yuzuru Otsuka, Masahiko Kato, Shin-ichi Taniguchi, Kazuhiro Yamamoto   +14 more
doaj   +1 more source

Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes

Microbial Cell Factories, 2009
Background Nikkomycins are a group of peptidyl nucleoside antibiotics and act as potent inhibitors of chitin synthases in fungi and insects. Nikkomycin X and Z are the main components produced by Streptomyces ansochromogenes.
Yang Haihua, Li Lei, Li Jine, Liao Guojian, Tian Yuqing, Tan Huarong   +5 more
doaj   +1 more source

Novel imidazoles from guanylhydrazone: Synthesis, computational, and molecular docking studies as α-amylase inhibitors for type 2 diabetes management

Results in Chemistry
This study reports a facile synthesis of novel imidazole derivatives as potential α-amylase inhibitors for type 2 diabetes management. Starting with readily available precursors (p-chloroacetophenone and aminoguanidine), guanylhydrazone 3 was synthesized
Mohamed G. Badrey, Ahmed A. Elhenawy, Mohammad Mahboob Alam, Syed Nazreen, Magdi E.A. Zaki, Sobhi M. Gomha   +5 more
doaj   +1 more source