Results 61 to 70 of about 1,538 (160)

Computational Investigation of Mechanism and Selectivity in (3+2) Cycloaddition Reactions Involving Azaoxyallyl Cations

Reactions
Azaoxyallyl cations, as novel and versatile three-atom components, have been widely utilized in cycloaddition reactions, with the competition between O- and N-cyclization pathways remaining a key research focus.
Wei Zhou, Lei Zhang, Guixian Liu, Xiaosi Ma, Xiangtai Meng   +4 more
doaj   +1 more source

Knocking out histidine ammonia-lyase by using CRISPR-Cas9 abolishes histidine role in the bioenergetics and the life cycle of Trypanosoma cruzi

Microbial Cell
Trypanosoma cruzi, the causing agent of Chagas disease, is the only known trypanosomatid pathogenic to humans having a complete histidine to glutamate pathway, which involves a series of four enzymatic reactions that convert histidine into downstream ...
Janaína de Freitas Nascimento, María Julia Barisón, Gabriela Torres Montanaro, Letícia Marchese, Rodolpho Ornitz Oliveira Souza, Letícia Sophia Silva, Alessandra Aparecida Guarnieri, Ariel Mariano Silber   +7 more
doaj   +1 more source

Chemical Investigation of the Calcareous Marine Sponge Pericharax heteroraphis, Clathridine-A Related Derivatives Isolation, Synthesis and Osteogenic Activity

Marine Drugs
As a result of screening a panel of marine organisms to identify lead molecules for the stimulation of endochondral bone formation, the calcareous sponge Pericharax heteroraphis was identified to exhibit significant activity during endochondral ...
Capucine Jourdain de Muizon, Céline Moriou, Marceau Levasseur, David Touboul, Bogdan I. Iorga, Hristo Nedev, Elsa Van Elslande, Pascal Retailleau, Sylvain Petek, Eric Folcher, Arnaud Bianchi, Mireille Thomas, Solène Viallon, Sylvie Peyroche, Sarah Nahle, Marthe Rousseau, Ali Al-Mourabit   +16 more
doaj   +1 more source

An In Silico Approach for Comparative Characterization of Imidazolonepropionase from Agrobacterium fabrum & Bacillus subtilis: An Imperative Enzyme for Histidine Degradation

Biology and Life Sciences Forum
Introduction: The third step in histidine degradation is catalysed by imidazolonepropionase. It catalyses the conversion of 4-imidazolone-5-propionic acid to produce N-formimino-L-glutamic acid by hydrolyzing the carbon-nitrogen bonds. The histidine is a
Ishita Biswas, Trishanjan Biswas, Debanjan Mitra   +2 more
doaj   +1 more source

Protein glycation products associate with progression of kidney disease and incident cardiovascular events in individuals with type 1 diabetes

Cardiovascular Diabetology
Background Despite improved glycemic treatment, the impact of glycation on pathological consequences may persist and contribute to adverse clinical outcomes in diabetes. In the present study we investigated the association between serum protein glycation
Krishna Adeshara, Daniel Gordin, Anni A. Antikainen, Valma Harjutsalo, Niina Sandholm, Markku J. Lehto, Per-Henrik Groop, on behalf of the FinnDiane Study Group   +7 more
doaj   +1 more source

Dietary advanced glycation end products and risk of cardiometabolic disorders in older adults: cross-sectional data from the 2007–2021 Korea National Health and Nutrition Examination Survey (KNHANES)

BMC Nutrition
Background Advanced glycation end products (AGEs) have been identified as potential dietary risk factors for cardiometabolic disorders. Despite studies in Western populations, little is known about the impact of AGEs in elderly Asian with different ...
Arti Sharma, Jimi Kim
doaj   +1 more source

Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds. [PDF]

Angew Chem Int Ed Engl, 2023
Nadal Rodríguez P, Ghashghaei O, Schoepf AM, Benson S, Vendrell M, Lavilla R.   +5 more
europepmc   +2 more sources

Diagnostic and therapeutic significance of selected antibodies against advanced glycation end-products (anti-AGEs). [PDF]

Mol Biol Rep
Sobczyńska J, Federowicz J, Galińska Z, Ziomek M, Stach W, Bronowicka-Szydełko A, Madziarska K.   +6 more
europepmc   +1 more source

Synthesis of new substituted thieno[2,3-d]imidazolone from hydantoin

ARKIVOC, 2007
Lalla Aïcha Ba, Gilbert Kirsch, Jérémie Castello   +2 more
doaj   +1 more source

Targeting cell cycle and apoptotic pathways with newly synthesized diselenide-linked imidazolone analogues with strong CDK6-targeting potential. [PDF]

RSC Adv
Abdel-Motaal M, Shaaban S, Hawas SS, Elsharif AM, Sharaky M, Alatawi FS, Eissa ME, Al Khatib AO, Abd El-Lateef HM, Asem M, Al-Karmalawy AA.   +10 more
europepmc   +1 more source