Results 41 to 50 of about 1,538 (160)

Bioinspired Light‐Driven Organic Rotary Molecular Systems

ChemistryEurope, Volume 4, Issue 1, January 2026.
This review explores the evolution of bioinspired light‐driven rotary molecular systems (RMSs), highlighting the integration of natural chromophore‐based fragments to enhance quantum efficiency, photostability, and biocompatibility. Key strategies to optimize photochemical performance and broaden functional applications are discussed, providing a ...
Lidia Hortigüela, Sara P. Morcillo
wiley   +1 more source

Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64Cu PET/MRI

British Journal of Pharmacology, Volume 183, Issue 2, Page 268-279, January 2026.
Background and Purpose Methanobactins are peptides with high copper affinity and potential to treat Wilson disease. We examined how two methanobactins (ARBM101 and MB‐OB3b) affected copper handling in the LPP Atp7b−/− Wilson disease rat model, compared to penicillamine or saline, by 64Cu positron emission tomography/magnetic resonance imaging ...
Emilie Munk Lynderup, Mikkel Holm Vendelbo, Frederik Teicher Kirk, Karina Højrup Vase, Aage Kristian Olsen Alstrup, Tamara Rieder, Alan A. DiSpirito, Jeremy D. Semrau, Tea Lund Laursen, Peter Ott, Hans Zischka, Thomas Damgaard Sandahl   +11 more
wiley   +1 more source

Rational Design of 7‐Azaindole‐Based Robust Microporous Hydrogen‐Bonded Organic Framework for Gas Sorption

Angewandte Chemie, Volume 137, Issue 1, January 2, 2025.
A preorganized tetrapodal building block, incorporating α‐carboline units, self‐assembles to form a 3D hydrogen‐bonded organic framework (HOF). The expanded hydrogen bonding between the heteroaromatic substructures, along with intermolecular π–π interactions, spontaneously build up an interpenetrated architecture that bestows an extraordinary ...
Manuel Carrera, Ion Such‐Basáñez, Juan Pablo Marco‐Lozar, Agustín Bueno‐López, Eduardo Vilaplana‐Ortego, Iván da Silva, Delia Bautista, Alberto Fernández‐Alarcón, Joaquín Calbo, Enrique Ortí, David Curiel   +10 more
wiley   +2 more sources

Histamine as a marker for hydroxyl radicals

Mediators of Inflammation, 1995
During inflammation an influx of neutrophils and release of mediators from mast cells (such as histamine) take place. The stimulated neutrophils can produce reactive oxygen species (ROS). One of these ROS is the highly reactive hydroxyl radical (OH.). It
T.-L. Ching, R. M. van der Hee, N. M. Bhoelan, J. Blauw, W. M. P. B. Menge, J. de Jong, A. Bast   +6 more
doaj   +1 more source

Fingertip skin autofluorescence as a non‐invasive marker for vascular complications in patients with type 2 diabetes

Journal of Diabetes Investigation, Volume 16, Issue 12, Page 2201-2212, December 2025.
This multicenter study demonstrated that fingertip autofluorescence, measured non‐invasively, correlates with clinical risk factors and vascular complications in patients with type 2 diabetes. Our findings suggest that fingertip autofluorescence may serve as a convenient marker for evaluating both microvascular and macrovascular complications in ...
Minoru Takeshita, Takeshi Matsumura, Aiko Arimura, Hiroyuki Takahashi, Yoshimi Muta, Shigeru Kawade, Dai Yamagami, Takahisa Deguchi, Tatsuya Kondo, Mikihiro Yamanaka, Ryoji Nagai, Daiji Kawanami, Toshihiko Yanase, Takashi Nomiyama, Yoshihiko Nishio, Eiichi Araki, Naoto Kubota   +16 more
wiley   +1 more source

Synthesis of 2-Arylsubstituted Imidazolone Derivatives

Bulletin of the Korean Chemical Society, 2007
Since imidazolones have been found to be associated with their various biological activities such as potassium channel opener, phosphodiesterase III/IV inhibition, and crop protection, this class of compounds has become a synthetic target for organic and medicinal chemists. Due to increased interest, several synthetic approaches of these compounds have
Joo Hi Kang, Jong Taik Moon, Jungahn Kim, Dong Jun Joo, Jae Yeol Lee   +4 more
openaire   +3 more sources

X‐Ray Crystal Structures and Complete 1H/13C NMR Resonance Assignment of the 5‐HT4 Receptor Agonist BIMU8 and its Hydrochloride

ChemistrySelect, Volume 10, Issue 44, November 24, 2025.
X‐ray and NMR were utilized to determine the crystal structure of BIMU8 (N‐[(1R,5S)‐8‐methyl‐8‐azabicyclo[3.2.1]octan‐3‐yl]‐2‐oxo‐3‐propan‐2‐ylbenzimidazole‐1‐carboxamide) and its hydrochloride. High‐quality crystal structures were obtained for both the free base and the hydrochloride salt. Abstract BIMU8 (N‐[(1R,5S)‐8‐methyl‐8‐azabicyclo[3.2.1]octan‐3‐
Hoai Thi Tran, Markus Bacher, Alexander Prado‐Roller, Thomas Rosenau, Stefan Böhmdorfer   +4 more
wiley   +1 more source

Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance

Molecules, 2020
Multidrug resistance (MDR) is a severe problem in the treatment of cancer with overexpression of glycoprotein P (Pgp, ABCB1) as a reason for chemotherapy failure.
Aneta Kaczor, Márta Nové, Annamária Kincses, Gabriella Spengler, Ewa Szymańska, Gniewomir Latacz, Jadwiga Handzlik   +6 more
doaj   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, Volume 12, Issue 31, August 21, 2025.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

A Direct Measurement of the Absolute Energies of Protonated Gly‐Pro‐Gly‐Gly Conformations Using Ion Mobility Spectrometry and Guided Ion Beam Tandem Mass Spectrometry

ChemPhysChem, Volume 26, Issue 12, June 23, 2025.
Relative energies of the cis and trans conformers of the protonated tetrapeptide, Gly‐Pro‐Gly‐Gly, selected by ion mobility spectrometry are measured using threshold collision‐induced dissociation. The trans conformation was found to be more stable than the cis conformation by 4.5 ± 2.5 kJ mol−1 at 0 K, a value in agreement with several levels of ...
Brandon C. Stevenson, Shannon A. Raab, David E. Clemmer, Peter B. Armentrout   +3 more
wiley   +1 more source