Results 21 to 30 of about 1,538 (160)
Chemistry, 2023 Finding an effective anticancer drug to combat cancer cell resistance remains a challenge. Herein, we synthesized a new series of imidazolone derivatives 4a–4i and assessed their anticancer activities against liver cancer cells (Hep3B), Hela cells, and ...
Saber Abu-Jabal +10 more
doaj +1 more source
Identification and study of new NF-κB-inducing kinase ligands derived from the imidazolone scaffold. [PDF]
Arch Pharm (Weinheim)A new family of NF‐κB‐inducing kinase (NIK) ligands bearing an imidazolone moiety were synthesized. The best compound showed a dose‐dependent inhibition of p100 to p50 processing in cellular assays, a key step in nuclear factor κB (NF‐κB) activation. Based on computational techniques, a plausible binding mode is proposed.
Maqueda-Zelaya F +8 more
europepmc +2 more sources
Synthesis of 2-Imidazolones and 2-Iminoimidazoles [PDF]
Organic Letters, 2011 Convenient methods for the direct conversion of imidazolium salts to the corresponding 2-imidazolone or 2-imino imidazole derivatives have been developed. Treatment of the salt with commercial bleach leads to effective oxidation at C2 and the formation of the corresponding imidazolone. Alternatively, treatment of the salt with an N-chloro amide affords
Heather M, Lima, Carl J, Lovely
openaire +2 more sources
Kondensierte Imidazolone / Condensed Imidazolones
Zeitschrift für Naturforschung B, 1985 11-13. The dehydrogenation of 2-tert-amino-2,2-diphenyl-acetamides with cyclic amine components gives under neighbouring the corresponding condensed imidazolones With analogous reactions of 2-tert-amino-2-phenylacetamides on dependence of the ring size of the amine cycle, a different course is observed resulting in the ...
Hans Möhrle, Hans-Jörg Hemmerling
openaire +1 more source
Chemistry Proceedings, 2023 In this study, we investigated the conformational abilities of n,n’-(Alkanediyl)-bis(2-phenyl-3,5-dihydro-4H-imidazol-4-one)s (1) to gain insight into their biological potential as a platform for the generation of various QACs. Among the conformers of 1,
Anastasia A. Lobankova +2 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 A new series of vinyl amide-, imidazolone-, and triazinone-linked combretastatin A-4 analogues have been designed and synthesised. These compounds have been evaluated for their cytotoxic activity against MDA-MB-231 breast cancer cells.
Islam Zaki +6 more
doaj +1 more source
Increased Yields of the Guanine Oxidative Damage Product Imidazolone Following Exposure to LED Light
Reactions, 2023 Among the bases of DNA, guanine is the most easily oxidized. Imidazolone (Iz) is a guanine oxidative damage, and we sought to generate Iz-containing oligomers. In this paper, we describe the methods and conditions to increase the yield of Iz by employing
Taishu Kawada +2 more
doaj +1 more source
SKN-1 regulates stress resistance downstream of amino catabolism pathways
iScience, 2022 Summary: The deleterious potential to generate oxidative stress is a fundamental challenge to metabolism. The oxidative stress response transcription factor, SKN-1/NRF2, can sense and respond to changes in metabolic state, although the mechanism and ...
Phillip A. Frankino +7 more
doaj +1 more source
Molecules, 2011 A novel series of 7,7-diphenyl-1,2-dihydroimidazo[2,1-c][1,2,4]triazin-6(7H)-one 6a–h, were easily prepared via reactions of novel 2-hydrazinyl-4,4-diphenyl-1H-imidazol-5(4H)-one (2) with hydrazonoyl halides 3a–h.
Huwaida M.E. Hassaneen +1 more
doaj +1 more source
Chalcone-imidazolone conjugates induce apoptosis through DNA damage pathway by affecting telomeres
Cancer Cell International, 2011 Background Breast cancer is one of the most prevalent cancers in the world and more than one million women are diagnosed leading to 410,000 deaths every year.
Kamal Ahmed +7 more
doaj +1 more source